Research Project
Grant-in-Aid for Young Scientists (B)
The transcriptional repressor Bach2 acts as a key regulator of T cell-mediated immune homeostasis. However, molecular mechanisms by which Bach2 controls T cell-mediated immune homeostasis remain unclear. We found that Bach2 associates with transcriptional factor Batf and binds to the Th2 cytokine gene loci including the Il4 enhancer and locus control regions both of which containing AP-1 motifs, which led to the inhibition of IL-4 production. Furthermore, the spontaneous development of Th2-type lung inflammation and accelerated Th2 cell differentiation caused by the T cell-specific Bach2 deficiency was normalized by the T cell-specific deletion of the Batf gene. These results indicated that Bach2-Batf complex is required to repress the Th2-type immune responses. We also showed that Bach2 inhibits the senescence-associated secretory phenotype (SASP) in senescent CD4 T cells. These findings reveal a critical role of the Bach2 in regulating CD4 T cell-mediated immune homeostasis.
All 2016 2015 2014 Other
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 3 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (6 results) Remarks (1 results)
Immunology
Volume: 147 Issue: 4 Pages: 476-487
10.1111/imm.12580
International Immunology
Volume: 27 Issue: 3 Pages: 143-152
10.1093/intimm/dxu092
Nature Comm
Volume: 5 Issue: 1 Pages: 3555-3555
10.1038/ncomms4555
http://www.jst.go.jp/pr/announce/20140402-2/
