An investigation of the role of the transcription repressor Bach2 in CD4 T cell-mediated immune homeostasis
Project/Area Number |
25860376
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Ehime University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
Yamashita Masakatsu 愛媛大学, 大学院医学系研究科免疫学, 教授 (00311605)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | Th2 / 免疫老化 / Bach2 |
Outline of Final Research Achievements |
The transcriptional repressor Bach2 acts as a key regulator of T cell-mediated immune homeostasis. However, molecular mechanisms by which Bach2 controls T cell-mediated immune homeostasis remain unclear. We found that Bach2 associates with transcriptional factor Batf and binds to the Th2 cytokine gene loci including the Il4 enhancer and locus control regions both of which containing AP-1 motifs, which led to the inhibition of IL-4 production. Furthermore, the spontaneous development of Th2-type lung inflammation and accelerated Th2 cell differentiation caused by the T cell-specific Bach2 deficiency was normalized by the T cell-specific deletion of the Batf gene. These results indicated that Bach2-Batf complex is required to repress the Th2-type immune responses. We also showed that Bach2 inhibits the senescence-associated secretory phenotype (SASP) in senescent CD4 T cells. These findings reveal a critical role of the Bach2 in regulating CD4 T cell-mediated immune homeostasis.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells2016
Author(s)
Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita
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Journal Title
Immunology
Volume: 147
Issue: 4
Pages: 476-487
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis2014
Author(s)
Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
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Journal Title
Nature Comm
Volume: 5
Issue: 1
Pages: 3555-3555
DOI
Related Report
Peer Reviewed / Open Access
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