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Development of new vulnerable plaque specific arteriosclerosis diagnostic method using FRET method

Research Project

Project/Area Number 25860393
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionOkayama University

Principal Investigator

Ogawa Hiroko  岡山大学, 大学病院, 助教 (70423283)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈硬化 / イメージング
Outline of Final Research Achievements

In the present study, we aimed to develop a method for detecting the more sensitive unstable plaque. We consider to use the fact that extracellular matrix degrading enzymes is expressed in unstable plaques. Labeled with fluorescence protein as a substrate, it was planning to encapsulated in liposomes. Takes time to create the recombinant protein, it took time than expected. In addition, the labeling of the fluorescence of the recombinant protein was also created, resulting in a delay in the research plan. The study period was completed, but continue, is expected to continue the research.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results)

  • [Journal Article] Emergence of Daptomycin-Resistant <i>Staphylococcus aureus</i> during Treatment2016

    • Author(s)
      Hagiya H, Haruki Y, Uchida T, Wada T, Shiota S, Ishida T, Ogawa H, Murase T, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 1 Pages: 73-78

    • DOI

      10.2169/internalmedicine.55.4763

    • NAID

      130005116787

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eagle's Syndrome Manifesting as Chronic Swallowing Pain2015

    • Author(s)
      Hagiya H, Waseda K, Ogawa H, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 10 Pages: 1321-1321

    • DOI

      10.2169/internalmedicine.54.4262

    • NAID

      130005069775

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infective Internal Iliac Artery Aneurysm Caused by <i>Campylobacter fetus</i>2015

    • Author(s)
      Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Hanayama Y, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 16 Pages: 2021-2024

    • DOI

      10.2169/internalmedicine.54.4845

    • NAID

      130005092908

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>Actinomyces turicensis</i> Bacteremia Secondary to Pyometra2015

    • Author(s)
      Hagiya H, Ogawa H, Takahashi Y, Kimura K, Hasegawa K, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 21 Pages: 2775-2777

    • DOI

      10.2169/internalmedicine.54.4637

    • NAID

      130005106615

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>Klebsiella oxytoca</i>-producing IMP-1 Detected as the First Strain of Carbapenem-resistant <i>Enterobacteriaceae</i> in Our Hospital2015

    • Author(s)
      Hagiya H, Ogawa H, Takahashi Y, Yamamoto A, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 22 Pages: 2939-2941

    • DOI

      10.2169/internalmedicine.54.4965

    • NAID

      130005108843

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Nephrostomy-associated Urinary Tract Infection Caused by <i>Elizabethkingia meningoseptica</i>2015

    • Author(s)
      Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Iwamuro M, Otsuka F.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 24 Pages: 3233-3236

    • DOI

      10.2169/internalmedicine.54.4998

    • NAID

      130005114249

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aortic vascular graft infection caused by Cardiobacterium valvarum: a case report.2014

    • Author(s)
      Hagiya H, Kokeguchi S, Ogawa H, Terasaka T, Kimura K, Waseda K, Hanayama Y, Oda K, Mori H, Miyoshi T, Otsuka F.
    • Journal Title

      J Infect Chemother.

      Volume: 20(12) Issue: 12 Pages: 804-809

    • DOI

      10.1016/j.jiac.2014.07.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent Stenotrophomonas maltophilia bacteremia after iliac crest bone graft harvest.2014

    • Author(s)
      Hagiya H, Ogawa H, Ishida T, Terasaka T, Kimura K, Waseda K, Hanayama Y, Horita M, Shimamura Y, Kondo E, Otsuka F.
    • Journal Title

      Intern Med.

      Volume: 53 Pages: 1693-8

    • NAID

      130004678368

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor2014

    • Author(s)
      Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek MZ, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S
    • Journal Title

      Exp Cell Res

      Volume: 323(2) Issue: 2 Pages: 263-75

    • DOI

      10.1016/j.yexcr.2014.03.002

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2014-07-25   Modified: 2019-07-29  

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