Development of new vulnerable plaque specific arteriosclerosis diagnostic method using FRET method

• Project/Area Number: 25860393
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Okayama University
• Principal Investigator: Ogawa Hiroko 岡山大学, 大学病院, 助教 (70423283)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 動脈硬化 / イメージング

Outline of Final Research Achievements

In the present study, we aimed to develop a method for detecting the more sensitive unstable plaque. We consider to use the fact that extracellular matrix degrading enzymes is expressed in unstable plaques. Labeled with fluorescence protein as a substrate, it was planning to encapsulated in liposomes. Takes time to create the recombinant protein, it took time than expected. In addition, the labeling of the fluorescence of the recombinant protein was also created, resulting in a delay in the research plan. The study period was completed, but continue, is expected to continue the research.

Research Products

• [Journal Article] Emergence of Daptomycin-Resistant <i>Staphylococcus aureus</i> during Treatment (2016)
  • Author(s): Hagiya H, Haruki Y, Uchida T, Wada T, Shiota S, Ishida T, Ogawa H, Murase T, Otsuka F.
  • Journal Title: Internal Medicine Volume: 55 Issue: 1 Pages: 73-78
  • DOI: 10.2169/internalmedicine.55.4763
  • NAID: 130005116787
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Eagle's Syndrome Manifesting as Chronic Swallowing Pain (2015)
  • Author(s): Hagiya H, Waseda K, Ogawa H, Otsuka F.
  • Journal Title: Internal Medicine Volume: 54 Issue: 10 Pages: 1321-1321
  • DOI: 10.2169/internalmedicine.54.4262
  • NAID: 130005069775
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Infective Internal Iliac Artery Aneurysm Caused by <i>Campylobacter fetus</i> (2015)
  • Author(s): Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Hanayama Y, Otsuka F.
  • Journal Title: Internal Medicine Volume: 54 Issue: 16 Pages: 2021-2024
  • DOI: 10.2169/internalmedicine.54.4845
  • NAID: 130005092908
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] <i>Actinomyces turicensis</i> Bacteremia Secondary to Pyometra (2015)
  • Author(s): Hagiya H, Ogawa H, Takahashi Y, Kimura K, Hasegawa K, Otsuka F.
  • Journal Title: Internal Medicine Volume: 54 Issue: 21 Pages: 2775-2777
  • DOI: 10.2169/internalmedicine.54.4637
  • NAID: 130005106615
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] <i>Klebsiella oxytoca</i>-producing IMP-1 Detected as the First Strain of Carbapenem-resistant <i>Enterobacteriaceae</i> in Our Hospital (2015)
  • Author(s): Hagiya H, Ogawa H, Takahashi Y, Yamamoto A, Otsuka F.
  • Journal Title: Internal Medicine Volume: 54 Issue: 22 Pages: 2939-2941
  • DOI: 10.2169/internalmedicine.54.4965
  • NAID: 130005108843
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] A Nephrostomy-associated Urinary Tract Infection Caused by <i>Elizabethkingia meningoseptica</i> (2015)
  • Author(s): Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Iwamuro M, Otsuka F.
  • Journal Title: Internal Medicine Volume: 54 Issue: 24 Pages: 3233-3236
  • DOI: 10.2169/internalmedicine.54.4998
  • NAID: 130005114249
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Aortic vascular graft infection caused by Cardiobacterium valvarum: a case report. (2014)
  • Author(s): Hagiya H, Kokeguchi S, Ogawa H, Terasaka T, Kimura K, Waseda K, Hanayama Y, Oda K, Mori H, Miyoshi T, Otsuka F.
  • Journal Title: J Infect Chemother. Volume: 20(12) Issue: 12 Pages: 804-809
  • DOI: 10.1016/j.jiac.2014.07.008
  • Peer Reviewed
• [Journal Article] Recurrent Stenotrophomonas maltophilia bacteremia after iliac crest bone graft harvest. (2014)
  • Author(s): Hagiya H, Ogawa H, Ishida T, Terasaka T, Kimura K, Waseda K, Hanayama Y, Horita M, Shimamura Y, Kondo E, Otsuka F.
  • Journal Title: Intern Med. Volume: 53 Pages: 1693-8
  • NAID: 130004678368
  • Peer Reviewed / Open Access
• [Journal Article] ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor (2014)
  • Author(s): Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek MZ, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S
  • Journal Title: Exp Cell Res Volume: 323(2) Issue: 2 Pages: 263-75
  • DOI: 10.1016/j.yexcr.2014.03.002
  • Peer Reviewed / Open Access