Novel treatment strategy for colorectal cancer based on genetic/ epigenetic information
Project/Area Number |
25860409
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | Okayama University |
Principal Investigator |
Umeda Yuzo 岡山大学, 大学病院, 助教 (10573735)
|
Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Toshiyoshi 岡山大学, 医歯薬学総合研究科 消化器外科, 教授 (00304303)
YAGI Takahito 岡山大学, 大学病院 肝胆膵外科, 教授 (00304353)
NAGASAKA Takeshi 岡山大学, 大学病院 消化器外科, 講師 (30452569)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 大腸癌 / 大腸癌肝転移 / 遺伝子解析 |
Outline of Final Research Achievements |
We previously reported that genetic information has an essential role as a prognostic/predictive marker in treatment strategy for colorectal cancer (CRC). The aim of the research was to discover novel epigenetic biomarkers. BRAF V600E was initially focused on because microsatellite stable (MSS) CRC with BRAF V600E mutation(mt) fails to extremely poor outcome. We analyzed 17-gene methylation panel that consists of different methylation loci in BRAF V600E with MSS and microsatellite instability (MSI). This analysis identified demethylation of O6-methylguanine DNA methyltransferase (MGMT). BRAF V600E-mt with MSS didn’t show MGMT methylation, while that with MSI showed partial or extensive methylation of MGMT promoter. And this could be observed in KRAS-mt and wild type CRC. In utilization to the patient cohort of stage II/III CRC (n=223), MGMT hyper methylation associated with improved relapse-free survival. In conclusion, MGMT methylation status could be a promising biomarker of CRC.
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Report
(4 results)
Research Products
(129 results)
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[Journal Article] Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.2016
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Tanaka T, Kimura K, Taniguchi F, Fuji T, Shigeyasu K, Mori Y, Yanai H, Yagi T, Goel A, Fujiwara T.
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Journal Title
J Cancer Res Clin Oncol.
Volume: -
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-high mobility group box 1 monoclonal antibody improves ischemia/reperfusion injury and mode of liver regeneration after partial hepatectomy.2016
Author(s)
Sugihara M, Sadamori H, Nishibori M, Sato Y, Tazawa H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Ohno K, Nagasaka T, Yoshino T, Takahashi HK, Yagi T, Fujiwara T.
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Journal Title
Am J Surg.
Volume: 211(1)
Pages: 179-188
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma.2016
Author(s)
Uchida D, Takaki A, Ishikawa H, Tomono Y, Kato H, Tsutsumi K, Tamaki N, Maruyama T, Tomofuji T, Tsuzaki R, Yasunaka T, Koike K, Matsushita H, Ikeda F, Miyake Y, Shiraha H, Nouso K, Yoshida R, Umeda Y, Shinoura S, Yagi T, Fujiwara T, Morita M, Fukushima M, Yamamoto K, Okada H.
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Journal Title
Free Radic Res.
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.2015
Author(s)
Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: e0130409-e0130409
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.2015
Author(s)
Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, Taniguchi F, Yasui K, Kubota N, Takehara Y, Tazawa H, Kagawa S, Sun DS, Nishida N, Goel A, Fujiwara T.
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Journal Title
Clin Epigenetics
Volume: 7
Issue: 1
Pages: 73-73
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Enhancement of Programmed Death Ligand 2 on Hepatitis C Virus Infected Hepatocytes by Calcineurin Inhibitors.2015
Author(s)
Koike K, Takaki A, Yagi T, Iwasaki Y, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Miyake Y, Ikeda F, Shiraha H, Fujiwara T, Yamamoto K
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Journal Title
Transplantation
Volume: 99(7)
Issue: 7
Pages: 1447-1454
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study2015
Author(s)
Terao M, Takaki A, Maruyama T, Oe H, Yasunaka T, Tamaki N, Nakamura K, Tomofuji T, Yagi T, Sadamori H, Umeda Y, Shinoura S, Yoshida R, Nouso K, Ekuni D, Koike K, Ikeda F, Shiraha H, Morita M, Ito H, Fujiwara T, Yamamoto K.
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Journal Title
Internal Medicine
Volume: 54
Issue: 22
Pages: 2815-2826
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula.2015
Author(s)
Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Watanabe N, Kuise T, Sui K, Hirose A, Tsuboi M, Ogasawara M, Iwasaki S, Saibara T, Fujiwara T.
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Journal Title
Hepatol Res.
Volume: -
Issue: 13
Pages: 1409-1415
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Frequency of regulatory T-cell and hepatitis C viral antigen-specific immune response in recurrent hepatitis C after liver transplantation2014
Author(s)
Utsumi M, Takaki A, Umeda Y, Koike K, Napier SC, Watanabe N, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Nakayama E, Yamamoto K, Fujiwara T, Yagi T
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Journal Title
Transplant Immunology
Volume: 1
Pages: 33-41
Related Report
Peer Reviewed / Open Access
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[Journal Article] Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas of surgical anatomy (with video)2014
Author(s)
Nobuoka D, Fuji T, Yoshida K, Takagi K, Kuise T, Utsumi M, Yoshida R, Umeda Y, Shinoura S, Takeda Y, Ohtsuka A
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Journal Title
Journal of Hepato-Biliary Pancreatic Sciences
Volume: 21
Pages: 556-561
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hepatitis C virus-specific t-cell response correlates with hepatitis activity and donor IL28B genotype early after liver transplantation2014
Author(s)
Tsuzakia R, Takakia A, Yagi T, Ikeda F, Koike K, Iwasaki Y, Shiraha H, Miyake Y, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Nakayama E, Fujiwara T, Yamamoto K
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Journal Title
Acta Medica Okayama
Volume: 68
Pages: 291-302
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] 日本人肝硬変患者における肝肺症候群 移植前血液ガススクリーニングの結果より2014
Author(s)
岡田早未, 高木章乃夫, 八木孝仁, 安中哲也, 後藤田達洋, 麻植浩樹, 中村一文, 佐藤秀一, 貞森裕, 篠浦先, 楳田祐三, 吉田龍一, 内海方嗣, 信岡大輔, 保田裕子, 池田房雄, 三宅康広, 伊藤浩, 藤原俊義, 山本和秀
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Journal Title
肝臓
Volume: 55
Pages: 143-154
NAID
Related Report
Peer Reviewed
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[Journal Article] Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria.2013
Author(s)
Utsumi M, Umeda Y, Sadamori H, Nagasaka T, Takaki A, Matsuda H, Shinoura S, Yoshida R, Nobuoka D, Satoh D, Fuji T, Yagi T, Fujiwara T
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Journal Title
Transpl Int
Volume: 26(8)
Issue: 8
Pages: 842-852
DOI
Related Report
Peer Reviewed
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[Journal Article] Serial changes of serum growth factor levels and liver regeneration after partial hepatectomy in healthy humans.2013
Author(s)
Matsumoto K, Miyake Y, Umeda Y, Matsushita H, Matsuda H, Takaki A, Sadamori H, Nouso K, Yagi T, Fujiwara T, Yamamoto K.
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Journal Title
Int J Mol Sci
Volume: 17(14)
Issue: 10
Pages: 20877-20889
DOI
Related Report
Peer Reviewed
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[Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013
Author(s)
Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
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Journal Title
J Gastroenterol
Volume: 48(12)
Issue: 12
Pages: 1373-1383
DOI
Related Report
Peer Reviewed
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[Presentation] 安全で確実な腹腔鏡下肝切除を目指して~開腹肝切除からのKnow-how~2015
Author(s)
楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬 崇, 須井健太, 高木弘誠, 木村裕司, 八木孝仁, 藤原俊義
Organizer
第28回日本内視鏡外科学会総会
Place of Presentation
大阪
Year and Date
2015-12-10
Related Report
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[Presentation] 大腸癌ゲノム情報を用いた肝転移治療戦略2015
Author(s)
永坂岳司, 楳田祐三, 母里淑子, 岸本浩行, 近藤喜太, 浅野博昭, 佃 和憲, 篠浦 先, 西﨑正彦, 香川俊輔, 白川靖博, 八木孝仁, 藤原俊義
Organizer
第53回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
2015-10-30
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[Presentation] 進行膵癌に対する標準治療+新規ペプチドワクチン療法 第Ⅱ相臨床試験2015
Author(s)
楳田祐三, 鈴木伸明, 信岡大輔, 藤原俊義, 井口東郎, 田中浩明, 有賀 淳, 石崎秀信, 島田光生, 吉松和彦, 清水良一, 林 弘人, 坂田晃一朗, 硲 彰一, 岡 正朗
Organizer
第53回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
2015-10-30
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[Presentation] 腹腔鏡下肝切除の適応拡大に向けたcadaver trainingの実際2015
Author(s)
信岡大輔, 八木孝仁, 近藤喜太, 佐藤博紀, 森廣俊昭, 高木弘誠, 安井和也, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 大塚愛二, 藤原俊義
Organizer
第13回日本消化器外科学会大会
Place of Presentation
大阪
Year and Date
2015-10-09
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[Presentation] Intrahepatic arterioportal fistulaに伴う門脈圧亢進症に対して脳死肝移植術を施行した1例2015
Author(s)
高木弘誠, 吉田龍一, 篠浦 先, 楳田祐三, 信岡大輔, 渡辺信之, 杭瀬 崇, 須井健太, 木村裕司, 吉田真理, 保田裕子, 八木孝仁, 藤原俊義
Organizer
第51回日本移植学会総会
Place of Presentation
熊本市
Year and Date
2015-10-03
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[Presentation] 肝移植術前管理と肝移植後の難治性腹水におけるトルバプタンの有効性2015
Author(s)
楳田祐三, 八木孝仁, 高木章乃夫, 篠浦 先, 吉田龍一, 信岡大輔, 安中哲也, 渡辺信之, 杭瀬 崇, 高木弘誠, 保田裕子, 藤原俊義
Organizer
第51回日本移植学会総会
Place of Presentation
熊本
Year and Date
2015-10-02
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[Presentation] 肝臓移植における血管吻合とくに非顕微鏡的肝動脈再建と肝静脈・下大静脈置換の手技2015
Author(s)
八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 渡辺信之, 高木弘誠, 須井健太, 木村裕司, 藤原俊義, 吉田真理, 保田裕子, 高木章乃夫
Organizer
第51回日本移植学会総会
Place of Presentation
熊本市
Year and Date
2015-10-02
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[Presentation] 移植医療人の役割分担と協調はどうあるべきか:外科医、内科医、コーディネーターの関係2015
Author(s)
八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 渡辺信之, 高木弘誠, 須井健太, 木村裕司, 藤原俊義, 吉田真理, 保田裕子, 高木章乃夫
Organizer
第51回日本移植学会総会
Place of Presentation
熊本市
Year and Date
2015-10-02
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[Presentation] Detection of circulating Ago2-miRNAs predict tumor response to anti-tumor therapies2015
Author(s)
Fuji T, Nagasaka T, Umeda Y, Mori Y, Kawai T, Taniguchi F, Kimura K, Toshima T, Yasui K, Goel A, Fujiwara T
Organizer
The European Cancer Congress 2015
Place of Presentation
Vienna, Austria
Year and Date
2015-09-28
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Int'l Joint Research
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[Presentation] Non invasive detection of methylated CpGs from sputum can predict patiets with lung cancer2015
Author(s)
Kawai T, Nagasaka T, Takehara Y, Umeda Y, Fuji T, Taniguchi F, Kimura K, Toshima T, Yasui K, Mori Y, Kishimoto H, Toyooka S, Goel A, Fujiwara T
Organizer
The European Cancer Congress 2015
Place of Presentation
Vienna, Austria
Year and Date
2015-09-28
Related Report
Int'l Joint Research
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[Presentation] Systematic genetic analysis of familial adenomatous polyposis and lynch syndrome2015
Author(s)
Taniguchi F, Nagasaka T, Takehara Y, Umeda Y, Mori Y, Kawai T, Fuji T, Toshima T, Kimura K, Yasui K, Goel A, Fujiwara T
Organizer
The European Cancer Congress 2015
Place of Presentation
Vienna, Austria
Year and Date
2015-09-27
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Int'l Joint Research
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[Presentation] 肝移植後肝癌再発に対する治療成績2015
Author(s)
渡辺信之, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 須井健太, 高木弘誠, 木村裕司, 藤原俊義, 八木孝仁
Organizer
第33回中国四国臨床臓器移植研究会
Place of Presentation
高松市
Year and Date
2015-08-29
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[Presentation] 遺伝子変異解析によるIPMN悪性度診断の新展開2015
Author(s)
安井和也, 楳田祐三, 永坂岳司, 吉田一博, 藤 智和, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 八木孝仁, 藤原俊義
Organizer
第27回日本肝胆膵外科学会・学術集会
Place of Presentation
東京
Year and Date
2015-06-12
Related Report
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[Presentation] 急性肝不全に対する内科的治療と肝移植の現状2015
Author(s)
楳田祐三, 賀来隆治, 安中哲也, 篠浦 先, 吉田龍一, 信岡大輔, 松崎 孝, 保田裕子, 高木章乃夫, 藤原俊義, 八木孝仁
Organizer
第33回日本肝移植研究会
Place of Presentation
神戸
Year and Date
2015-05-29
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[Presentation] Systematic Genomic Characterization of Normal Mucosa, Adenomatous Polyps, and Cancer in Patients With Familial Adenomatous Polyposis2015
Author(s)
Taniguchi F, Nagasaka T, Takehara Y, Umeda Y, Mori Y, Kawai T, Fuji T, Toshima T, Kimura K, Goel A, Fujiwara T
Organizer
Digestive Disease Week2015
Place of Presentation
Washington DC
Year and Date
2015-05-19
Related Report
Int'l Joint Research
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[Presentation] nherent Single Nucleotide Variants in the TBX21 Gene As Novel Prognostic Markers in Patients With Pancreatic Ductal & Adenocarcinoma2015
Author(s)
Fuji T, Umeda Y, Nagasaka T, Taniguchi F, Takehara Y, Kawai T, Kimura K, Toshima T, Yagi T, Goel A, Fujiwara T
Organizer
Digestive Disease Week2015
Place of Presentation
Washington DC
Year and Date
2015-05-16
Related Report
Int'l Joint Research
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[Presentation] 膵切除後の残膵腫瘍に対する再膵切除2015
Author(s)
渡邉佑介, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 内海正嗣, 杭瀬 崇, 高木弘誠, 八木孝仁, 藤原俊義
Organizer
第115回日本外科学会定期学術集会
Place of Presentation
名古屋
Year and Date
2015-04-17
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[Presentation] 膵頭十二指腸切除術の手技習得に向けたcadaver trainingの実際2015
Author(s)
信岡大輔, 八木孝仁, 近藤喜太, 森廣俊昭, 高木弘誠, 藤 智和, 渡邉佑介, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 日置勝義, 藤原俊義
Organizer
第115回日本外科学会定期学術集会
Place of Presentation
名古屋
Year and Date
2015-04-16
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[Presentation] 直腸癌術後肺再発に対するCTガイド下経皮的ラジオ波焼灼の短期・長期成績の検討2014
Author(s)
稲田 涼, 永坂岳司, 松本 聖, 母里淑子, 近藤喜太, 岸本浩行, 浅野博昭, 佃 和憲, 楳田祐三, 平木隆夫, 金澤 右, 八木孝仁, 藤原俊義
Organizer
第80回大腸癌研究会
Place of Presentation
東京
Year and Date
2014-12-04
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[Presentation] Clinical role of promoter hypermethylation in the MGMT gene during colorectal tumorigenesis2014
Author(s)
Nagasaka T, Mori Y, Umeda Y, Takehara Y, Kawai T, Taniguchi F, Fuji T, Toshima T, Inada R, Kondo Y, OharaT, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Yagi T, Fujiwara T
Organizer
第25回日本消化器癌発生学会総会・第8回国際消化器癌発生会議
Place of Presentation
福岡
Year and Date
2014-11-13 – 2014-11-14
Related Report
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[Presentation] ペプチドゲルを用いた新規局所止血剤の開発と腹腔鏡下肝切除における使用法2014
Author(s)
信岡大輔, 八木孝仁, 田村周太, 富丸慶人, 永野浩昭, 高木弘誠, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 貞森 裕, 藤原俊義
Organizer
第27回日本内視鏡外科学会総会
Place of Presentation
盛岡
Year and Date
2014-10-02 – 2014-10-04
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[Presentation] Hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter as a prognostic biomarker for stage Ⅱ,Ⅲ and Ⅳcolorectal cancers2014
Author(s)
Mori Y, Nagasaka T, Umeda Y, Shiwaku R. Inada R, Nishida N, Kishimoto H, Kagawa S, Tanioka H, Mishima H, Fujiwara T, Goel A
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid, スペイン
Year and Date
2014-09-26 – 2014-09-30
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[Presentation] Cytokeratin 19, a novel prognostic biomarker for hepatocellular carcinoma, is regulated by DNA methylation2014
Author(s)
Yokomichi N, Nagasaka T, Nishida N, Taniguchi F, Yoshida K, Tomokazu F, Kawai T, Takehara Y, Kimura K, Mori Y, Inada R, Umeda Y, Yagi T, Goel A, Fujiwara T
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid, スペイン
Year and Date
2014-09-26 – 2014-09-30
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[Presentation] Extensive methylation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) promoter could predict malignant formation in intraductal papillary mucinous neoplasms (IPMN)2014
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Takehara Y, Takehara K, Kawai T, Tomokazu F, Taniguchi F, Yagi T, Goel A, Fujiwara T
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid, スペイン
Year and Date
2014-09-26 – 2014-09-30
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[Presentation] 臨床病期Ⅱ&Ⅲ直腸癌の遺伝子変異情報及び臨床病理学的所見と予後の検討2014
Author(s)
永坂岳司, 岸本浩行, 母里淑子, 稲田 涼, 近藤喜太, 竹原裕子, 河合 毅, 藤 智和, 谷口文崇, 横道直佑, 久保田暢人, 吉田一博, 楳田祐三, 八木孝仁, 藤原俊義
Organizer
第52回日本癌治療学会学術集会
Place of Presentation
横浜
Year and Date
2014-08-28 – 2014-08-30
Related Report
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[Presentation] 膵臓癌切除患者におけるSarcopeniaの存在とその意義に関する検討2014
Author(s)
高木弘誠, 吉田龍一, 熊野健二郎, 杭瀬 崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 貞森 裕, 八木孝仁, 藤原俊義
Organizer
第52回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
2014-08-28 – 2014-08-30
Related Report
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[Presentation] 肝臓内視鏡外科手術に有用な局所止血材の開発2014
Author(s)
信岡大輔, 八木孝仁, 田村周太, 小松星児, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 貞森 裕, 藤原俊義
Organizer
第69回日本消化器外科学会総会
Place of Presentation
郡山
Year and Date
2014-07-16 – 2014-07-18
Related Report
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[Presentation] 生体肝移植におけるリスク因子としての高齢ドナーと背景疾患との関連性2014
Author(s)
楳田祐三, 高木弘誠, 杭瀬 崇, 内海方嗣, 信岡大輔, 吉田龍一, 篠浦 先, 保田裕子, 高木章乃夫, 藤原俊義, 八木孝仁
Organizer
第32回日本肝移植研究会
Place of Presentation
東京
Year and Date
2014-07-03 – 2014-07-04
Related Report
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[Presentation] 肝移植後の腎機能の経過と降圧療法について2014
Author(s)
高木章乃夫, 八木孝仁, 保田裕子, 安中哲也, 貞森裕, 篠浦先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 藤原俊義, 山本和秀
Organizer
第32回日本肝移植研究会
Place of Presentation
東京
Year and Date
2014-07-03 – 2014-07-04
Related Report
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[Presentation] 再肝移植症例に対する手技的工夫2014
Author(s)
八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 高木弘誠, 杭瀬 崇, 藤原俊義
Organizer
第32回日本肝移植研究会
Place of Presentation
東京
Year and Date
2014-07-03 – 2014-07-04
Related Report
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[Presentation] Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas system of surgical anatomy2014
Author(s)
Nobuoka D, Fuji T, Yoshida K, Takagi K, Kuise T, Utsumi M, Yoshida R, Umeda Y, Shinoura S, Yagi T, Fujiwara T
Organizer
第26回日本肝胆膵外科学会
Place of Presentation
和歌山
Year and Date
2014-06-11 – 2014-06-13
Related Report
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[Presentation] 肝移植後肝癌再発に対する集学的治療2014
Author(s)
楳田祐三, 八木孝仁, 貞森 裕, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 横道直佑, 藤 智和, 谷口文崇, 高木弘誠, 藤原俊義
Organizer
第50回日本肝癌研究会
Place of Presentation
京都
Year and Date
2014-06-05 – 2014-06-06
Related Report
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[Presentation] 遺伝子変異情報を用いた直腸癌局所再発症例に対する治療戦略の検討2014
Author(s)
永坂岳司, 母里淑子, 楳田祐三, 稲田 涼, 森川達也, 横道直佑, 久保田暢人, 吉田一博, 竹原裕子, 河合 毅, 藤 智和, 竹原清人, 杭瀬 崇, 谷口文崇, 近藤喜太, 岸本浩行, 浅野博昭, 佃 憲和, 貞森 裕, 八木孝仁, 藤原俊義
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都
Year and Date
2014-04-03 – 2014-04-05
Related Report
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[Presentation] 大腸癌肺転移に対するCTガイド下経皮的ラジオ波焼却の短期・長期成績の検討2014
Author(s)
稲田 涼, 永坂岳司, 松本聖, 母里淑子, 近藤喜太, 岸本浩行, 楳田祐三, 浅野博昭, 佃和憲, 横道直佑, 久保田暢人, 河合毅, 吉田一博, 竹原清人, 森川達也, 竹原裕子, 平木隆夫, 金澤右, 八木孝仁, 藤原俊義
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都
Year and Date
2014-04-03 – 2014-04-05
Related Report
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[Presentation] TREATMENT STRATEGY FOR COLORECTAL LIVER METASTASIS BASED ON GENETIC PROFILES2013
Author(s)
Umeda Y, Nagasaka T, Mori Y, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Yagi T, Fujiwara T
Organizer
21st United European Gastroenterology Week
Place of Presentation
Berlin、ドイツ
Related Report
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[Presentation] Accumulation of Epigenetic Alteration Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasm(IPMN)2013
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Kubota N, Morikawa T, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando、アメリカ
Related Report
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[Presentation] MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery2013
Author(s)
Nagasaka T, Mori Y, Tazawa H, Umeda Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Yokomichi N, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando、アメリカ
Related Report
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[Presentation] Cytokeratin 19 Staining Is a Novel, Predictive Biomarker for Extra-Hepatic Metastasis in Hepatocellular Carcinoma2013
Author(s)
Yokomichi N, Nagasaka T, Nishida N, Umeda Y, Mori Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Fujiwara T, Goel A
Organizer
Digestive Disease Week 2013
Place of Presentation
Orlando、アメリカ
Related Report
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