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Novel treatment strategy for colorectal cancer based on genetic/ epigenetic information

Research Project

Project/Area Number 25860409
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionOkayama University

Principal Investigator

Umeda Yuzo  岡山大学, 大学病院, 助教 (10573735)

Co-Investigator(Renkei-kenkyūsha) FUJIWARA Toshiyoshi  岡山大学, 医歯薬学総合研究科 消化器外科, 教授 (00304303)
YAGI Takahito  岡山大学, 大学病院 肝胆膵外科, 教授 (00304353)
NAGASAKA Takeshi  岡山大学, 大学病院 消化器外科, 講師 (30452569)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords大腸癌 / 大腸癌肝転移 / 遺伝子解析
Outline of Final Research Achievements

We previously reported that genetic information has an essential role as a prognostic/predictive marker in treatment strategy for colorectal cancer (CRC).
The aim of the research was to discover novel epigenetic biomarkers. BRAF V600E was initially focused on because microsatellite stable (MSS) CRC with BRAF V600E mutation(mt) fails to extremely poor outcome. We analyzed 17-gene methylation panel that consists of different methylation loci in BRAF V600E with MSS and microsatellite instability (MSI). This analysis identified demethylation of O6-methylguanine DNA methyltransferase (MGMT). BRAF V600E-mt with MSS didn’t show MGMT methylation, while that with MSI showed partial or extensive methylation of MGMT promoter. And this could be observed in KRAS-mt and wild type CRC. In utilization to the patient cohort of stage II/III CRC (n=223), MGMT hyper methylation associated with improved relapse-free survival.
In conclusion, MGMT methylation status could be a promising biomarker of CRC.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (129 results)

All 2016 2015 2014 2013 2012

All Journal Article (30 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 30 results,  Open Access: 13 results,  Acknowledgement Compliant: 2 results) Presentation (98 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.2016

    • Author(s)
      Yoshida K, Nagasaka T, Umeda Y, Tanaka T, Kimura K, Taniguchi F, Fuji T, Shigeyasu K, Mori Y, Yanai H, Yagi T, Goel A, Fujiwara T.
    • Journal Title

      J Cancer Res Clin Oncol.

      Volume: - Issue: 7 Pages: 1-13

    • DOI

      10.1007/s00432-016-2164-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-high mobility group box 1 monoclonal antibody improves ischemia/reperfusion injury and mode of liver regeneration after partial hepatectomy.2016

    • Author(s)
      Sugihara M, Sadamori H, Nishibori M, Sato Y, Tazawa H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Ohno K, Nagasaka T, Yoshino T, Takahashi HK, Yagi T, Fujiwara T.
    • Journal Title

      Am J Surg.

      Volume: 211(1) Pages: 179-188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma.2016

    • Author(s)
      Uchida D, Takaki A, Ishikawa H, Tomono Y, Kato H, Tsutsumi K, Tamaki N, Maruyama T, Tomofuji T, Tsuzaki R, Yasunaka T, Koike K, Matsushita H, Ikeda F, Miyake Y, Shiraha H, Nouso K, Yoshida R, Umeda Y, Shinoura S, Yagi T, Fujiwara T, Morita M, Fukushima M, Yamamoto K, Okada H.
    • Journal Title

      Free Radic Res.

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.2015

    • Author(s)
      Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0130409-e0130409

    • DOI

      10.1371/journal.pone.0130409

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.2015

    • Author(s)
      Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, Taniguchi F, Yasui K, Kubota N, Takehara Y, Tazawa H, Kagawa S, Sun DS, Nishida N, Goel A, Fujiwara T.
    • Journal Title

      Clin Epigenetics

      Volume: 7 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s13148-015-0096-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancement of Programmed Death Ligand 2 on Hepatitis C Virus Infected Hepatocytes by Calcineurin Inhibitors.2015

    • Author(s)
      Koike K, Takaki A, Yagi T, Iwasaki Y, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Miyake Y, Ikeda F, Shiraha H, Fujiwara T, Yamamoto K
    • Journal Title

      Transplantation

      Volume: 99(7) Issue: 7 Pages: 1447-1454

    • DOI

      10.1097/tp.0000000000000572

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study2015

    • Author(s)
      Terao M, Takaki A, Maruyama T, Oe H, Yasunaka T, Tamaki N, Nakamura K, Tomofuji T, Yagi T, Sadamori H, Umeda Y, Shinoura S, Yoshida R, Nouso K, Ekuni D, Koike K, Ikeda F, Shiraha H, Morita M, Ito H, Fujiwara T, Yamamoto K.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 22 Pages: 2815-2826

    • DOI

      10.2169/internalmedicine.54.4889

    • NAID

      130005108847

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula.2015

    • Author(s)
      Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Watanabe N, Kuise T, Sui K, Hirose A, Tsuboi M, Ogasawara M, Iwasaki S, Saibara T, Fujiwara T.
    • Journal Title

      Hepatol Res.

      Volume: - Issue: 13 Pages: 1409-1415

    • DOI

      10.1111/hepr.12701

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例2015

    • Author(s)
      安井和也, 楳田祐三, 熊野健二郎, 田端雅弘, 大塚文男, 八木孝仁, 藤原俊義
    • Journal Title

      岡山医学会雑誌

      Volume: 127 Pages: 213-218

    • NAID

      130005116814

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分葉膵に付着した消化管重複症2015

    • Author(s)
      尾山貴徳, 野田卓男, 谷本光隆, 楳田祐三, 藤智和, 八木孝仁, 藤原俊義
    • Journal Title

      小児外科

      Volume: 46(12) Pages: 1269-1273

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The rare BRAF VK600-601E mutation as a possible indicator of poor prognosis in rectal carcinoma – a report of a case2015

    • Author(s)
      Mori Y, Nagasaka T, Mishima H, Umeda Y, Inada R, Kishimoto H, Goel A, Fujiwara T
    • Journal Title

      BMC Med Genet

      Volume: s12881-015 Pages: 0144-0147

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between Computed Tomography Imaging Features and Pathological Features of 41 Patients with Pancreatic Neuroendocrine tumors2015

    • Author(s)
      Utsumi M, Umeda Y, Takagi K, Kuise T,Yoshida R, Nobuoka D, Shinoura S, Sadamori H, Yagi T, Fujiwara T
    • Journal Title

      Hepatogastroenterology

      Volume: 62 Pages: 441-446

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequency of regulatory T-cell and hepatitis C viral antigen-specific immune response in recurrent hepatitis C after liver transplantation2014

    • Author(s)
      Utsumi M, Takaki A, Umeda Y, Koike K, Napier SC, Watanabe N, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Nakayama E, Yamamoto K, Fujiwara T, Yagi T
    • Journal Title

      Transplant Immunology

      Volume: 1 Pages: 33-41

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] First successful case of simultaneous liver and kidney transplantation for patients with chronic liver and renal failure in Japan2014

    • Author(s)
      Yagi T, Nobuoka D, Shinoura S, Umeda Y, Sato D, Yoshida R, Utsumi M, Fuji T, Sadamori H, Fujiwara T
    • Journal Title

      Hepatology Research

      Volume: 44 Pages: 358-363

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas of surgical anatomy (with video)2014

    • Author(s)
      Nobuoka D, Fuji T, Yoshida K, Takagi K, Kuise T, Utsumi M, Yoshida R, Umeda Y, Shinoura S, Takeda Y, Ohtsuka A
    • Journal Title

      Journal of Hepato-Biliary Pancreatic Sciences

      Volume: 21 Pages: 556-561

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors of morbidity and predictors of long-term survival after hepatopancreatoduodenectomy for biliary cancer2014

    • Author(s)
      Utsumi M, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Takagi K, Fujiwara T, Yagi T
    • Journal Title

      Hepatogastroenterology

      Volume: 61 Pages: 2167-2172

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus-specific t-cell response correlates with hepatitis activity and donor IL28B genotype early after liver transplantation2014

    • Author(s)
      Tsuzakia R, Takakia A, Yagi T, Ikeda F, Koike K, Iwasaki Y, Shiraha H, Miyake Y, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Nakayama E, Fujiwara T, Yamamoto K
    • Journal Title

      Acta Medica Okayama

      Volume: 68 Pages: 291-302

    • NAID

      120005477131

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 同時性肝内転移、膵転移を伴った肝原発solitary fibrous tumorの1例2014

    • Author(s)
      杭瀬崇, 楳田祐三, 貞森裕, 篠浦先, 吉田龍一, 佐藤太祐, 信岡大輔, 内海方嗣, 八木孝仁, 藤原俊義
    • Journal Title

      日本消化器外科学会雑誌

      Volume: 47 Pages: 215-222

    • NAID

      130004561005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 日本人肝硬変患者における肝肺症候群 移植前血液ガススクリーニングの結果より2014

    • Author(s)
      岡田早未, 高木章乃夫, 八木孝仁, 安中哲也, 後藤田達洋, 麻植浩樹, 中村一文, 佐藤秀一, 貞森裕, 篠浦先, 楳田祐三, 吉田龍一, 内海方嗣, 信岡大輔, 保田裕子, 池田房雄, 三宅康広, 伊藤浩, 藤原俊義, 山本和秀
    • Journal Title

      肝臓

      Volume: 55 Pages: 143-154

    • NAID

      130003393968

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] First successful case of simultaneous liver and kidney transplantation for patients with chronic liver and renal failure in Japan2014

    • Author(s)
      Yagi T, Nobuoka D, Shinoura S, Umeda Y, Sato D, Yoshida R, Utsumi M, Fuji T, Sadamori H, Fujiwara T.
    • Journal Title

      Hepatol Res.

      Volume: 44(3) Issue: 3 Pages: 358-363

    • DOI

      10.1111/hepr.12122

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria.2013

    • Author(s)
      Utsumi M, Umeda Y, Sadamori H, Nagasaka T, Takaki A, Matsuda H, Shinoura S, Yoshida R, Nobuoka D, Satoh D, Fuji T, Yagi T, Fujiwara T
    • Journal Title

      Transpl Int

      Volume: 26(8) Issue: 8 Pages: 842-852

    • DOI

      10.1111/tri.12138

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serial changes of serum growth factor levels and liver regeneration after partial hepatectomy in healthy humans.2013

    • Author(s)
      Matsumoto K, Miyake Y, Umeda Y, Matsushita H, Matsuda H, Takaki A, Sadamori H, Nouso K, Yagi T, Fujiwara T, Yamamoto K.
    • Journal Title

      Int J Mol Sci

      Volume: 17(14) Issue: 10 Pages: 20877-20889

    • DOI

      10.3390/ijms141020877

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013

    • Author(s)
      Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K
    • Journal Title

      J Gastroenterol

      Volume: 48(12) Issue: 12 Pages: 1373-1383

    • DOI

      10.1007/s00535-013-0763-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] New surgical approach to large splenorenal shunt in living donor liver transplantation: diversion of SMV and SPV blood flow2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Gastrointest Surg

      Volume: 17 Issue: 2 Pages: 403-407

    • DOI

      10.1007/s11605-012-2006-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for organ/space surgical site infection after hepatectomy for hepatocellular carcinoma in 359 recent cases.2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Issue: 2 Pages: 180-196

    • DOI

      10.1007/s00534-011-0503-5

    • NAID

      10031168209

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy2013

    • Author(s)
      Satoh D、Yagi T、Nagasaka T、Shinoura S、Umeda Y、Yoshida R、Utsumi M、Tanaka T、Sadamori H、Fujiwara T
    • Journal Title

      World J Hepatol

      Volume: Vol.5、No.4 Issue: 4 Pages: 189-195

    • DOI

      10.4254/wjh.v5.i4.189

    • NAID

      120005324792

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bloodless donor hepatectomy in living donor liver transplantation: counterclockwise liver rotation and early hanging maneuver.2013

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      J Gastrointest Surg.

      Volume: 17 Issue: 1 Pages: 203-206

    • DOI

      10.1007/s11605-012-1907-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation to a survivor of liver resection for hepatocellular carcinoma with major portal vein invasion.2013

    • Author(s)
      Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Fujiwara T.
    • Journal Title

      Acta Med Okayama

      Volume: 67(2) Pages: 117-21

    • NAID

      120005232502

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.2012

    • Author(s)
      Yuzo Umeda
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Issue: 2 Pages: 223-233

    • DOI

      10.1007/s00534-012-0531-9

    • NAID

      10031168213

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: report of a case.2012

    • Author(s)
      Hiroshi Sadamori
    • Journal Title

      Hepatology Research

      Volume: 20 Issue: 12 Pages: 117-121

    • DOI

      10.1111/hepr.12080

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 安全で確実な腹腔鏡下肝切除を目指して~開腹肝切除からのKnow-how~2015

    • Author(s)
      楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬 崇, 須井健太, 高木弘誠, 木村裕司, 八木孝仁, 藤原俊義
    • Organizer
      第28回日本内視鏡外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 外科周術期真菌感染症におけるcaspofunginの有用性2015

    • Author(s)
      楳田祐三
    • Organizer
      感染症講演会 In Okayama 2015
    • Place of Presentation
      岡山
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大腸癌ゲノム情報を用いた肝転移治療戦略2015

    • Author(s)
      永坂岳司, 楳田祐三, 母里淑子, 岸本浩行, 近藤喜太, 浅野博昭, 佃 和憲, 篠浦 先, 西﨑正彦, 香川俊輔, 白川靖博, 八木孝仁, 藤原俊義
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 進行膵癌に対する標準治療+新規ペプチドワクチン療法 第Ⅱ相臨床試験2015

    • Author(s)
      楳田祐三, 鈴木伸明, 信岡大輔, 藤原俊義, 井口東郎, 田中浩明, 有賀 淳, 石崎秀信, 島田光生, 吉松和彦, 清水良一, 林 弘人, 坂田晃一朗, 硲 彰一, 岡 正朗
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腹腔鏡下肝切除の適応拡大に向けたcadaver trainingの実際2015

    • Author(s)
      信岡大輔, 八木孝仁, 近藤喜太, 佐藤博紀, 森廣俊昭, 高木弘誠, 安井和也, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 大塚愛二, 藤原俊義
    • Organizer
      第13回日本消化器外科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Intrahepatic arterioportal fistulaに伴う門脈圧亢進症に対して脳死肝移植術を施行した1例2015

    • Author(s)
      高木弘誠, 吉田龍一, 篠浦 先, 楳田祐三, 信岡大輔, 渡辺信之, 杭瀬 崇, 須井健太, 木村裕司, 吉田真理, 保田裕子, 八木孝仁, 藤原俊義
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝移植術前管理と肝移植後の難治性腹水におけるトルバプタンの有効性2015

    • Author(s)
      楳田祐三, 八木孝仁, 高木章乃夫, 篠浦 先, 吉田龍一, 信岡大輔, 安中哲也, 渡辺信之, 杭瀬 崇, 高木弘誠, 保田裕子, 藤原俊義
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓移植における血管吻合とくに非顕微鏡的肝動脈再建と肝静脈・下大静脈置換の手技2015

    • Author(s)
      八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 渡辺信之, 高木弘誠, 須井健太, 木村裕司, 藤原俊義, 吉田真理, 保田裕子, 高木章乃夫
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 移植医療人の役割分担と協調はどうあるべきか:外科医、内科医、コーディネーターの関係2015

    • Author(s)
      八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 渡辺信之, 高木弘誠, 須井健太, 木村裕司, 藤原俊義, 吉田真理, 保田裕子, 高木章乃夫
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Detection of circulating Ago2-miRNAs predict tumor response to anti-tumor therapies2015

    • Author(s)
      Fuji T, Nagasaka T, Umeda Y, Mori Y, Kawai T, Taniguchi F, Kimura K, Toshima T, Yasui K, Goel A, Fujiwara T
    • Organizer
      The European Cancer Congress 2015
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non invasive detection of methylated CpGs from sputum can predict patiets with lung cancer2015

    • Author(s)
      Kawai T, Nagasaka T, Takehara Y, Umeda Y, Fuji T, Taniguchi F, Kimura K, Toshima T, Yasui K, Mori Y, Kishimoto H, Toyooka S, Goel A, Fujiwara T
    • Organizer
      The European Cancer Congress 2015
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Systematic genetic analysis of familial adenomatous polyposis and lynch syndrome2015

    • Author(s)
      Taniguchi F, Nagasaka T, Takehara Y, Umeda Y, Mori Y, Kawai T, Fuji T, Toshima T, Kimura K, Yasui K, Goel A, Fujiwara T
    • Organizer
      The European Cancer Congress 2015
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝移植後肝癌再発に対する治療成績2015

    • Author(s)
      渡辺信之, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 須井健太, 高木弘誠, 木村裕司, 藤原俊義, 八木孝仁
    • Organizer
      第33回中国四国臨床臓器移植研究会
    • Place of Presentation
      高松市
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓外科領域における肝硬変と体液貯留管理2015

    • Author(s)
      楳田祐三
    • Organizer
      学術講演会「体液貯留管理を考える会
    • Place of Presentation
      岡山
    • Year and Date
      2015-08-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体肝移植の更なる発展を目指して~技術革新と手術戦略による移植予後の向上~2015

    • Author(s)
      楳田祐三, 八木孝仁, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 内海方嗣, 高木弘誠, 安井和也, 藤原俊義
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵神経内分泌腫瘍の Dynamic CT 画像所見についての検討2015

    • Author(s)
      内海方嗣, 楳田祐三, 高木弘誠, 杭瀬 崇, 信岡大輔, 吉田龍一, 篠浦 先, 八木孝仁, 藤原俊義
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵臓癌切除患者における sarcopenia が長期予後に及ぼす影響に関する検討2015

    • Author(s)
      高木弘誠, 吉田龍一, 杭瀬  崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦  先, 八木孝仁, 藤原俊義
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 再肝切除における根治性確保と合併症軽減に向けた工夫2015

    • Author(s)
      安井和也, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 高木弘誠, 八木孝仁, 藤原俊義
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における家族性大腸腺腫症に合併したデスモイド腫瘍の治療と予後2015

    • Author(s)
      母里淑子, 永坂岳司, 岸本浩行, 楳田祐三, 谷口文崇, 竹原裕子, 河合 毅, 藤 智和, 木村圭佑, 藤原俊義
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝子変異解析によるIPMN悪性度診断の新展開2015

    • Author(s)
      安井和也, 楳田祐三, 永坂岳司, 吉田一博, 藤 智和, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 八木孝仁, 藤原俊義
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 再使用可能なシリコンレプリカ膵臓を用いた膵管空腸吻合を用いた吻合トレーニングモデルの開発2015

    • Author(s)
      八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 高木弘誠, 佐藤博紀, 安井和也, 藤原俊義
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における十二指腸乳頭部腺腫/早期癌に対する治療成績2015

    • Author(s)
      吉田龍一, 加藤博也, 高木弘誠, 杭瀬 崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 八木孝仁, 藤原俊義
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝内胆管癌の外科治療~リンパ節郭清結果を踏まえ手術戦略を見直す~2015

    • Author(s)
      楳田祐三, 八木孝仁, 篠浦 先, 吉田龍一, 信岡大輔, 佐藤太祐, 杭瀬 崇, 高木弘誠, 安井和也, 藤原俊義
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家族性大腸線腫症における系統的遺伝子解析2015

    • Author(s)
      谷口文崇, 永坂岳司, 楳田祐三, 母里淑子, 河合 毅, 藤 智和, 戸嶋俊明, 木村圭佑, 藤原俊義
    • Organizer
      第22回日本家族性腫瘍学会学術集会
    • Place of Presentation
      埼玉市
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 急性肝不全に対する内科的治療と肝移植の現状2015

    • Author(s)
      楳田祐三, 賀来隆治, 安中哲也, 篠浦 先, 吉田龍一, 信岡大輔, 松崎 孝, 保田裕子, 高木章乃夫, 藤原俊義, 八木孝仁
    • Organizer
      第33回日本肝移植研究会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝腎同時移植の適応と問題点 ―3例の脳死下肝腎同時移植の経験から―2015

    • Author(s)
      八木孝仁, 吉田龍一, 篠浦 先, 信岡大輔, 楳田祐三, 杭瀬 崇, 高木弘誠, 藤原俊義
    • Organizer
      第33回日本肝移植研究会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Systematic Genomic Characterization of Normal Mucosa, Adenomatous Polyps, and Cancer in Patients With Familial Adenomatous Polyposis2015

    • Author(s)
      Taniguchi F, Nagasaka T, Takehara Y, Umeda Y, Mori Y, Kawai T, Fuji T, Toshima T, Kimura K, Goel A, Fujiwara T
    • Organizer
      Digestive Disease Week2015
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] nherent Single Nucleotide Variants in the TBX21 Gene As Novel Prognostic Markers in Patients With Pancreatic Ductal & Adenocarcinoma2015

    • Author(s)
      Fuji T, Umeda Y, Nagasaka T, Taniguchi F, Takehara Y, Kawai T, Kimura K, Toshima T, Yagi T, Goel A, Fujiwara T
    • Organizer
      Digestive Disease Week2015
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵癌における外科治療戦略~先行手術の問題点と術前療法の適応選別~2015

    • Author(s)
      藤 智和, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 高木弘誠, 八木孝仁, 藤原俊義
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体肝移植後の制御性T細胞とマイクロキメリズムの相関2015

    • Author(s)
      内海方嗣, 高木章乃夫, 高木弘誠, 杭瀬 崇, 信岡大輔, 吉田龍一, 楳田祐三, 篠浦 先, 藤原俊義, 八木孝仁
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵切除後の残膵腫瘍に対する再膵切除2015

    • Author(s)
      渡邉佑介, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 内海正嗣, 杭瀬 崇, 高木弘誠, 八木孝仁, 藤原俊義
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝細胞癌におけるサイトケラチン19の意義とメチル化の役割2015

    • Author(s)
      谷口文崇, 横道直佑, 永坂岳司, 楳田祐三, 河合 毅, 藤 智和, 竹原裕子, 木村圭祐, 八木孝仁, 藤原俊義
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 移植困難症例に対する手技的工夫:無肝期Veno-venous bypass使用による循環安定化の試み2015

    • Author(s)
      八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀨 崇, 高木弘誠, 藤原俊義
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵頭十二指腸切除術の手技習得に向けたcadaver trainingの実際2015

    • Author(s)
      信岡大輔, 八木孝仁, 近藤喜太, 森廣俊昭, 高木弘誠, 藤 智和, 渡邉佑介, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 日置勝義, 藤原俊義
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lecture 外科2014

    • Author(s)
      楳田祐三
    • Organizer
      The 5th Biliary Tract & Pancreatic Cancer Conference
    • Place of Presentation
      岡山
    • Year and Date
      2014-12-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 直腸癌術後肺再発に対するCTガイド下経皮的ラジオ波焼灼の短期・長期成績の検討2014

    • Author(s)
      稲田 涼, 永坂岳司, 松本 聖, 母里淑子, 近藤喜太, 岸本浩行, 浅野博昭, 佃 和憲, 楳田祐三, 平木隆夫, 金澤 右, 八木孝仁, 藤原俊義
    • Organizer
      第80回大腸癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical role of promoter hypermethylation in the MGMT gene during colorectal tumorigenesis2014

    • Author(s)
      Nagasaka T, Mori Y, Umeda Y, Takehara Y, Kawai T, Taniguchi F, Fuji T, Toshima T, Inada R, Kondo Y, OharaT, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Yagi T, Fujiwara T
    • Organizer
      第25回日本消化器癌発生学会総会・第8回国際消化器癌発生会議
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 遺伝子変異情報を用いた直腸癌局所再発症例に対する治療戦略の検討2014

    • Author(s)
      永坂岳司, 楳田祐三, 母里淑子, 稲田 涼, 岸本浩行, 戸嶋俊明, 竹原裕子, 竹原清人, 河合 毅, 藤原俊義
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] ペプチドゲルを用いた新規局所止血剤の開発と腹腔鏡下肝切除における使用法2014

    • Author(s)
      信岡大輔, 八木孝仁, 田村周太, 富丸慶人, 永野浩昭, 高木弘誠, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 貞森 裕, 藤原俊義
    • Organizer
      第27回日本内視鏡外科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter as a prognostic biomarker for stage Ⅱ,Ⅲ and Ⅳcolorectal cancers2014

    • Author(s)
      Mori Y, Nagasaka T, Umeda Y, Shiwaku R. Inada R, Nishida N, Kishimoto H, Kagawa S, Tanioka H, Mishima H, Fujiwara T, Goel A
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid, スペイン
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] MicroRNA-89 expression as a promising prognostic biomarker for advanced colorectal cancer2014

    • Author(s)
      Kubota N, Nagasaka T, Umeda Y, Mori Y, Kimura K, Taniguchi F, Tanioka H, Fujiwara T, Goel A
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid, スペイン
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Cytokeratin 19, a novel prognostic biomarker for hepatocellular carcinoma, is regulated by DNA methylation2014

    • Author(s)
      Yokomichi N, Nagasaka T, Nishida N, Taniguchi F, Yoshida K, Tomokazu F, Kawai T, Takehara Y, Kimura K, Mori Y, Inada R, Umeda Y, Yagi T, Goel A, Fujiwara T
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid, スペイン
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Extensive methylation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) promoter could predict malignant formation in intraductal papillary mucinous neoplasms (IPMN)2014

    • Author(s)
      Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Takehara Y, Takehara K, Kawai T, Tomokazu F, Taniguchi F, Yagi T, Goel A, Fujiwara T
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid, スペイン
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Risk analysis for small-for-size syndrome and acute renal injury after living donor liver transplantation2014

    • Author(s)
      Umeda Y, Yagi T, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Fujiwara T
    • Organizer
      14th Congress of the Middle East Society for Organ Transplantation
    • Place of Presentation
      Istanbul, トルコ
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Risk factors for invasive fungal infection after living donor liver transplantation : impact of meld score and acute renal injury2014

    • Author(s)
      Utsumi M, Umeda Y, Takagi K, Kuise T, Yoshida R, Shinoura S, Sadamori H, Fujiwara T, Yagi T
    • Organizer
      14th Congress of the Middle East Society for Organ Transplantation
    • Place of Presentation
      Istanbul, トルコ
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Is intention to treat for HCC a risk factor of liver-transplant outcome?2014

    • Author(s)
      Yagi T, Umeda Y, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Fujiwara T
    • Organizer
      14th Congress of the Middle East Society for Organ Transplantation
    • Place of Presentation
      Istanbul, トルコ
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Somatic mutation profiling in the RAS-RAF signal cascade: Promising predictive markers for extra-hepatic spreading in colorectal liver metastases2014

    • Author(s)
      Umeda Y, Nagasaka T, Mori Y, Taniguchi F, Fuji T, Shinoura S, Yagi T, Fujiwara T
    • Organizer
      The 52nd Annual Meeting of JSCO
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 臨床病期Ⅱ&Ⅲ直腸癌の遺伝子変異情報及び臨床病理学的所見と予後の検討2014

    • Author(s)
      永坂岳司, 岸本浩行, 母里淑子, 稲田 涼, 近藤喜太, 竹原裕子, 河合 毅, 藤 智和, 谷口文崇, 横道直佑, 久保田暢人, 吉田一博, 楳田祐三, 八木孝仁, 藤原俊義
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 腫瘍縮小にて膵頭十二指腸切除術を回避できた膵Solid-pseudopapillary neoplasmの1例2014

    • Author(s)
      信岡大輔, 八木孝仁, 篠浦 先, 高木弘誠, 杭瀬 崇, 内海方嗣, 吉田龍一, 楳田祐三, 貞森 裕, 藤原俊義
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 膵臓癌切除患者におけるSarcopeniaの存在とその意義に関する検討2014

    • Author(s)
      高木弘誠, 吉田龍一, 熊野健二郎, 杭瀬 崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 貞森 裕, 八木孝仁, 藤原俊義
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 再発肝細胞癌の治療方針~再肝切除の有効性とSalvage transplantationの可能性~2014

    • Author(s)
      藤 智和, 楳田祐三, 貞森 裕, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 八木孝仁, 藤原俊義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 肝臓内視鏡外科手術に有用な局所止血材の開発2014

    • Author(s)
      信岡大輔, 八木孝仁, 田村周太, 小松星児, 内海方嗣, 吉田龍一, 楳田祐三, 篠浦 先, 貞森 裕, 藤原俊義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 術後感染性合併症に繋がる脆弱性を識別する指標としてのSarcopenia~年齢区分を超えたリスク因子を求めて~2014

    • Author(s)
      高木弘誠, 吉田龍一, 杭瀬 崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 貞森 裕, 八木孝仁, 藤原俊義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 当科における進行胆嚢癌症例に対する外科切除成績~拡大手術の意義と限界~2014

    • Author(s)
      杭瀬 崇, 吉田龍一, 高木弘誠, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 貞森 裕, 八木孝仁, 藤原俊義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Tape re-positioningとEnergy deviceを活用した安全な高難度肝切除技術2014

    • Author(s)
      貞森 裕, 八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 高木弘誠, 藤原俊義
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体肝移植におけるリスク因子としての高齢ドナーと背景疾患との関連性2014

    • Author(s)
      楳田祐三, 高木弘誠, 杭瀬 崇, 内海方嗣, 信岡大輔, 吉田龍一, 篠浦 先, 保田裕子, 高木章乃夫, 藤原俊義, 八木孝仁
    • Organizer
      第32回日本肝移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 初診時肺転移を伴った切除不能肝芽腫に対し生体肝移植を施行した2例2014

    • Author(s)
      吉田龍一, 高木弘誠, 杭瀬 崇, 内海方嗣, 信岡大輔, 楳田祐三, 篠浦 先, 八木孝仁
    • Organizer
      第32回日本肝移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 肝移植後の腎機能の経過と降圧療法について2014

    • Author(s)
      高木章乃夫, 八木孝仁, 保田裕子, 安中哲也, 貞森裕, 篠浦先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 藤原俊義, 山本和秀
    • Organizer
      第32回日本肝移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 再肝移植症例に対する手技的工夫2014

    • Author(s)
      八木孝仁, 篠浦 先, 楳田祐三, 吉田龍一, 信岡大輔, 内海方嗣, 高木弘誠, 杭瀬 崇, 藤原俊義
    • Organizer
      第32回日本肝移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas system of surgical anatomy2014

    • Author(s)
      Nobuoka D, Fuji T, Yoshida K, Takagi K, Kuise T, Utsumi M, Yoshida R, Umeda Y, Shinoura S, Yagi T, Fujiwara T
    • Organizer
      第26回日本肝胆膵外科学会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 肝移植後肝癌再発に対する集学的治療2014

    • Author(s)
      楳田祐三, 八木孝仁, 貞森 裕, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 横道直佑, 藤 智和, 谷口文崇, 高木弘誠, 藤原俊義
    • Organizer
      第50回日本肝癌研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 大腸癌肝転移に対する再肝切除~根治性確保と合併症軽減に向けた工夫~2014

    • Author(s)
      楳田祐三, 八木孝仁, 貞森 裕, 篠浦 先, 吉田龍一, 信岡大輔, 内海方嗣, 杭瀬 崇, 高木弘誠, 藤原俊義
    • Organizer
      第68回手術手技研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌におけるprognostic factorとしてのmiRNA2014

    • Author(s)
      久保田暢人,永坂岳司,母里淑子,森川達也,吉田一博,横道直佑, 稲田 涼,竹原裕子,竹原清人, 河合 毅, 藤 智和, 楳田祐三,田澤 大, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Treatment strategy on the basis of risk analysis for small-for-size syndrome and acute renal injury after living donor liver transplantation2014

    • Author(s)
      Umeda Y, Yagi T, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Fujiwara T
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 遺伝子変異情報を用いた直腸癌局所再発症例に対する治療戦略の検討2014

    • Author(s)
      永坂岳司, 母里淑子, 楳田祐三, 稲田 涼, 森川達也, 横道直佑, 久保田暢人, 吉田一博, 竹原裕子, 河合 毅, 藤 智和, 竹原清人, 杭瀬 崇, 谷口文崇, 近藤喜太, 岸本浩行, 浅野博昭, 佃 憲和, 貞森 裕, 八木孝仁, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌肺転移に対するCTガイド下経皮的ラジオ波焼却の短期・長期成績の検討2014

    • Author(s)
      稲田 涼, 永坂岳司, 松本聖, 母里淑子, 近藤喜太, 岸本浩行, 楳田祐三, 浅野博昭, 佃和憲, 横道直佑, 久保田暢人, 河合毅, 吉田一博, 竹原清人, 森川達也, 竹原裕子, 平木隆夫, 金澤右, 八木孝仁, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 温阻血再灌流+肝切除モデルにおけるHMGB1制御による再灌流障害および肝再生への影響解析2014

    • Author(s)
      杉原正大,貞森 裕,西堀正洋,佐藤康晴,田澤 大,吉田龍一,楳田祐三,篠浦 先,永坂岳司,八木孝仁,藤原俊義,
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 幹細胞癌におけるサイトケラチン19の発現とメチル化の意義2014

    • Author(s)
      横道直佑,永坂岳司,楳田祐三,吉田一博,竹原裕子,河合 毅,藤 智和, 稲田 涼, 母里淑子, 八木孝仁, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 膵頭十二指腸切除症例における創部SSI危険因子の検討〜術前胆道ドレナージの合併症〜2014

    • Author(s)
      谷口文崇,八木孝仁, 貞森 裕,篠浦 先,楳田祐三, 吉田龍一,信岡大輔,内海方嗣,田村周太,高木弘誠,藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 膵頭十二指腸切除後の完全膵外瘻に対する非手術的内瘻化2014

    • Author(s)
      信岡大輔,八木孝仁,高木弘誠,田村周大,谷口文崇,内海方嗣,吉田龍一,楳田祐三,篠浦 先, 貞森 裕, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] TREATMENT STRATEGY FOR COLORECTAL LIVER METASTASIS BASED ON GENETIC PROFILES2013

    • Author(s)
      Umeda Y, Nagasaka T, Mori Y, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Utsumi M, Takagi K, Yagi T, Fujiwara T
    • Organizer
      21st United European Gastroenterology Week
    • Place of Presentation
      Berlin、ドイツ
    • Related Report
      2013 Research-status Report
  • [Presentation] Accumulation of Epigenetic Alteration Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasm(IPMN)2013

    • Author(s)
      Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Kubota N, Morikawa T, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando、アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery2013

    • Author(s)
      Nagasaka T, Mori Y, Tazawa H, Umeda Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Yokomichi N, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Nishida N, Fujiwara T, Goel A
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando、アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] Cytokeratin 19 Staining Is a Novel, Predictive Biomarker for Extra-Hepatic Metastasis in Hepatocellular Carcinoma2013

    • Author(s)
      Yokomichi N, Nagasaka T, Nishida N, Umeda Y, Mori Y, Morikawa T, Kubota N, Yoshida K, Takehara Y, Takehara K, Shigeyasu K, Nyuya A, Shiwaku R, Suno M, Fujiwara T, Goel A
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando、アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] The outcome of prophylatic surgical managements for spontaneous large splenorenal shunts adult living donor liver transplantation2013

    • Author(s)
      Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Fuji T, Takagi H, Fujiwara T
    • Organizer
      The 13th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] FREQUENCY OF REGULATORY T CELL AND HCV ANTIGEN SPECIFIC IMMUNE RESPONSE IN RECURRENT HEPATITIS C AFTER LIVER TRANSPLANTATION2013

    • Author(s)
      Utsumi M, Takaki A, Koike K, Umeda Y, Nobuoka D, Yoshida R, Shinoura S, Sadamori H, Fujiwara T, Yagi T
    • Organizer
      21st United European Gastroenterology Week
    • Place of Presentation
      Berlin、ドイツ
    • Related Report
      2013 Research-status Report
  • [Presentation] The risk factors for fungal infection after living donor liver transplantation2013

    • Author(s)
      Utsumi M, Umeda Y, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Yasuda Y, Takaki A, Fujiwara T, Yagi T
    • Organizer
      The 13th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子変異情報を基盤とした大腸癌肝転移の治療戦略2013

    • Author(s)
      楳田祐三,永坂岳司,母里淑子,稲田 涼,吉田龍一,篠浦 先,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝移植・肺移植における移植後二次発癌2013

    • Author(s)
      楳田祐三,八木孝仁,大藤剛宏,保田裕子,中谷 文,三好新一郎,藤原俊義
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 再発肝細胞癌の治療戦略~予後予測モデルとSalvage Transplantationの適応選別~2013

    • Author(s)
      楳田祐三,藤 智和,貞森 裕,篠浦 先,吉田龍一,佐藤太祐,信岡大輔,内海方嗣,藤原俊義,八木孝仁
    • Organizer
      第25回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      宇都宮市
    • Related Report
      2013 Research-status Report
  • [Presentation] 便中メチル化CpG検出による消化器癌診断2013

    • Author(s)
      永坂岳司,吉田一博,森川達也,母里淑子,横道直祐,久保田暢人,竹原祐子,稲田 涼,楳田祐三,西崎正彦,香川俊輔,西田直生志,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子変異情報を基盤とした大腸癌肝転移の治療戦略2013

    • Author(s)
      母里淑子,楳田祐三,永坂岳司,稲田 涼,森川達也,久保田暢人,吉田一博,篠浦 先,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌根治切除後の予後因子としてのMGMTプロモーターメチル化2013

    • Author(s)
      母里淑子,永坂岳司,楳田祐三,稲田 涼,重安邦俊,竹原裕子,森川達也,久保田暢人,横道直佑,吉田一博,藤 智和,河合 毅、杭瀬 崇,貞森 裕,藤原俊義
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌予後因子としてのMGMTプロモーターメチル化2013

    • Author(s)
      母里淑子,永坂岳司,楳田祐三,稲田 涼,重安邦俊,竹原裕子,森川達也,久保田暢人,佃 和憲,Ajay Goel,藤原俊義
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] StageIII大腸癌根治術後の再発予測におけるMGMTプロモーター領域のメチル化解析の有用性2013

    • Author(s)
      母里淑子,永坂岳司,竹原裕子,吉田一博,重安邦俊,楳田祐三,田澤 大,貞森 裕,藤原俊義
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Research-status Report
  • [Presentation] メチル化プロファイリングを用いたIntraductal papillary mucinous neoplasm(IPMN)2013

    • Author(s)
      吉田一博,永坂岳司,楳田祐三,横道直佑,母里淑子,久保田暢人,森川達也,竹原裕子,竹原清人,重安邦俊,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子情報を用いたStage IV大腸癌の検討および治療戦略2013

    • Author(s)
      稲田 涼,永坂岳司,母里淑子,楳田祐三,濱田侑紀,近藤喜太,宇野 太,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子情報を用いた多臓器転移大腸癌の検討および治療戦略の構築2013

    • Author(s)
      稲田 涼,永坂岳司,母里淑子,楳田祐三,森川達也,久保田暢人,近藤喜太,宇野 太,貞森 裕,八木孝仁,三嶋秀行,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子情報によるバイオマーカーを用いた進行・再発大腸癌の検討および治療戦略の確立2013

    • Author(s)
      稲田 涼,永坂岳司,母里淑子,楳田祐三,竹原裕子,森川達也,吉田一博,久保田暢人,横道直佑,近藤喜太,浅野博昭,佃 和憲,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子解析を用いたStageIV大腸癌に対する術前化学療法の検討および確立2013

    • Author(s)
      稲田 涼,永坂岳司,母里淑子,楳田祐三,森川達也,久保田暢人,近藤喜太,宇野 太,貞森 裕,八木孝仁,三嶋秀行,藤原俊義
    • Organizer
      第38回日本外科系連合学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子情報によるバイオマーカーを用いたStage IV大腸癌の治療戦略の構築2013

    • Author(s)
      稲田 涼,永坂岳司,母里淑子,楳田祐三,竹原裕子,森川達也,吉田一博,竹原清人,久保田暢人,近藤喜太,浅野博昭,佃 和憲,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 同時性多発大腸癌のsomatic mutation spectrumに対する検証2013

    • Author(s)
      森川達也,永坂岳司,玉川浩司,母里淑子,竹原清人,竹原裕子,吉田一博,稲田 涼,久保田暢人,楳田祐三,貞森 裕,藤原俊儀
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] サイトケラチン19は肝細胞癌の新規予後予測マーカーである2013

    • Author(s)
      横道直佑,永坂岳司,西田直生志,楳田祐三,森川達也,久保田暢人,吉田一博,竹原裕子,母里淑子,貞森 裕,八木孝仁,藤原俊義,Goel Ajay
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] サイトケラチン19発現は肝細胞癌の上皮間葉移行と肝外転移を予測する2013

    • Author(s)
      横道直佑,永坂岳司,西田直生志,楳田祐三,母里淑子,森川達也,久保田暢人,吉田一博,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝子変異解析によるIPMN悪性度診断の新展開2013

    • Author(s)
      吉田一博,楳田祐三,永坂岳司,藤 智和,母里淑子,篠浦 先,貞森 裕,八木孝仁,藤原俊義
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Research-status Report
  • [Presentation] HMGB1制御による阻血再灌流障害の軽減効果と肝再生機序への影響解析2013

    • Author(s)
      杉原正大,貞森 裕,篠浦 先,楳田祐三,吉田龍一,信岡大輔,内海方嗣,高木弘誠,藤原俊義,八木孝仁
    • Organizer
      第31回日本肝移植研究会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] 温阻血再灌流+肝切除モデルにおけるHMGB1の動態解析および肝再生機序の解明2013

    • Author(s)
      杉原正大,貞森 裕,西堀正洋,佐藤康晴,田澤 大,吉田龍一,楳田祐三,篠浦 先,永坂岳司,八木孝仁,藤原俊義
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] メチル化プロファイリングによるIPMNの悪性度予測2013

    • Author(s)
      吉田一博,永坂岳司,楳田祐三,横道直佑,母里淑子,久保田暢人,森川達也,竹原裕子,西江直生志,八木孝仁,Goel Ajay,藤原俊義
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] The Modulation of Portal Venous Hemodynamics in Living Donor Liver Transplantation2013

    • Author(s)
      Sadamori H, Umeda Y, Yagi T, Fujiwara T
    • Total Pages
      269
    • Publisher
      NOVA SCIENCE PUBLISHERS, INC
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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