Investigation of diagnostic marker for atherosclerotic disease by new bioactive peptide
Project/Area Number |
25860418
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
Sato Kengo 東京薬科大学, 生命科学部, 助教 (70549930)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 動脈硬化 / バイオマーカー / ペプチド / 血管内皮細胞 / マクロファージ / 血管平滑筋細胞 |
Outline of Final Research Achievements |
Cardiotrophin-1 (CT-1) and kisspeptin-10 (KP-10) enhanced foam-cell formation, but urocortin (Ucn) and tumor necrosis factor-stimulated gene-6 (TSG-6) suppressed foam cell formation in human macrophages. The migration and proliferation were stimulated by CT-1, suppressed by Ucn and TSG-6 in human vascular smooth muscle cell. Ucn and TSG-6 suppressed LPS-induced up-regulation of MCP1, IL6, ICAM1, and VCAM1 in human umbilical vein endothelial cells (HUVECs). Four-week-infusion of CT-1 and KP-10 into apolipoprotein E-deficient mice accelerated the development of aortic atherosclerotic lesions, whereas Ucn and TSG-6 retarded the atherogenesis. In coronary artery disease (CAD) patients, plasma TSG-6 levels were increased and TSG-6 was highly expressed in the fibrous cap within coronary atherosclerotic plaques. Thus, TSG-6 can be regarded as a novel therapeutic target and TSG-6 may be a candidate for biomarkers of CAD.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Counteractive effects of omentin-1 against atherogenesis2016
Author(s)
Watanabe K, Watanabe R, Konii H, Shirai R, Sato K, Matsuyama T, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T
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Journal Title
Cardiovasc Res
Volume: 110
Issue: 1
Pages: 118-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Facilitatory effects of fetuin-A on atherosclerosis2016
Author(s)
Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, Watanabe R, Sato K, Iso Y, Matsuyama T, Suzuki H, Ishibashi-Ueda H, Watanabe T
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Journal Title
Atherosclerosis
Volume: 246
Pages: 344-351
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Physiological fluctuations of human plasma total salusin-β, an endogenous parasympathomimetic/proatherosclerotic peptide2014
Author(s)
Ogawa A, Fujimoto K, Hayashi A, Chida S, Sato K, Takai K, Masaki T, Suzuki A, Kamata Y, Takano K, Koyama T, Shichiri M.
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Journal Title
Peptides
Volume: 59
Pages: 83-88
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin’s actions in nondiabetic and diabetic apolipoprotein E-null mice.2013
Author(s)
Terasaki M, Nagashima M, Nohtomi K, Kohashi K, Tomoyasu M, Sinmura K, Nogi Y, Katayama Y, Sato K, Itoh F, Watanabe T, Hirano T.
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Journal Title
PLoS ONE
Volume: 8
Issue: 8
Pages: e70933-e70933
DOI
Related Report
Peer Reviewed
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[Presentation] ounteractive Effects of Omentin-1 Against Atherogenesis.2015
Author(s)
Watanabe K, Watanabe R, Konii H, Shirai R, Sato K, Matsuyama T, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T.
Organizer
American Heart Association Scientific Sessions 2015
Place of Presentation
Orland, FL, USA
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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[Presentation] The suppressive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to the action of incretin in both nondiabetic and diabetic mice.2013
Author(s)
Terasaki M, Nagashima M, Nohtomi K, Kohashi K, Tomoyasu M, Ikado K, Nogi Y, Sato K, Itoh F, Watanabe T, Hirano T.
Organizer
49th Annual Meeting of the European Association for the Study of Diabetes
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Stimulatory effects of cardiotrophin-1 on atherosclerosis.2013
Author(s)
3. Watanabe T, Konii H, Kikuchi S, Okiyama H, Watanabe R, Hasegawa A, Yamamoto K, Sato K, Itoh F, Hirano T.
Organizer
American Heart Association Scientific Sessions 2013
Place of Presentation
Dallas, Texas, USA
Related Report
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