| Project/Area Number |
25860423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kobe University |
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Principal Investigator |
OBATA Norihiko 神戸大学, 医学部附属病院, 助教 (30509443)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経障害性疼痛 / アデノ随伴ウィルスベクター / 遺伝子治療 / 慢性痛 / 神経障害性痛 / 脳由来神経栄養因子 / siRNA |
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| Outline of Final Research Achievements |
The objective of this study is to inhibit the expression of brain-derived neurotrophic factor (BDNF), which plays a pivotal role in the development of neuropathic pain, using an adeno-associated virus vector (AAV).
First, we designed an AAV vector containing small interfering (si)RNA that inhibits the expression of specific BDNF related to pain. Then we plan to administer the AAV vector in the spinal subarachnoid space in animal pain models, confirm the BDNF synthesis inhibition in ganglia and examine its analgesic effect. Eventually, we intend to assess the safety of this therapy, and make this strategy developed in clinical.
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