Elucidation of spinal itch transmitters and development of antipruritic therapy
| Project/Area Number |
25860428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 難治性かゆみ / アトピー性皮膚炎 / 脊髄 / 神経伝達物質 / かゆみ / 脊髄後角 / 後根神経節 / 電気生理 |
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| Outline of Final Research Achievements |
This study was performed to reveal mechanisms of spinal itch transmission using in vivo electrophysiological, pharmacological and behavior methods. We found that SP, GRP, and glutamate each partially contribute to histamine-independent itch, whereas histamine-evoked itch is mediated primarily by glutamate. Co-application of NK-1, GRP, and AMPA receptor antagonists may prove beneficial in treating chronic and intractable itch such as atopic dermatitis. We are currently trying to investigate antipruritic therapeutic effects in chronic itch models such as dry skin and atopic dermatitis.
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Report
(3 results)
Research Products
(56 results)
