Mechanisms of noradrenaline-mediated modulation of synaptic plasticity in the nociceptive amygdala
| Project/Area Number |
25860429
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 情動 / 慢性痛 / シナプス可塑性 / 扁桃体 / 電気生理学 / ノルアドレナリン / 侵害受容性扁桃体 |
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| Outline of Final Research Achievements |
I have found the followings: first, noradrenaline applied to the acute brain slices containing the central amygdala potently modulated the synaptic transmission. Second, injection of anti-dopamine beta-hydroxylase-saporin into the central amygdala, which resulted in destroying of the noradrenergic fibers in the amygdala, changed in spontaneous pain-related behaviors and the thermal preference. Finally, I have established a system for Cre recombinase-dependent expression of channelrhodopsin in the noradrenergic neurons that would enable light-triggered release of intrinsic noradrenaline in vivo and ex vivo preparations.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Artificial association of pre-stored information to generate a qualitatively new memory2015
Author(s)
Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, Inokuchi K
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Journal Title
Cell Reports
Volume: 11
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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