In vivo patch-clamp analysis of itch transmission in central nerve system
| Project/Area Number |
25860431
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | University of Toyama (2014)
National Institute for Physiological Sciences (2013) |
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Principal Investigator |
UTA Daisuke 富山大学, 大学院医学薬学研究部(薬学), 助教 (70598416)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 痒み / 脊髄後角 / in vivoパッチクランプ / 5-ＨＴ / 痛み / 大脳皮質 / シナプス伝達 / 中枢神経 / セロトニン / c-Fos / TRP / in vivo patch clamp / 脊髄 / 膠様質ニューロン |
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| Outline of Final Research Achievements |
The mechanism for the itch transmission in the central nervous system remains unclear. The present study was designed to analyze pruritic synaptic responses evoked in spinal dorsal horn and cortex neurons of rodents by using an in vivo whole-cell patch-clamp and extracellular recording technique. The present main finding is that subpopulation of spinal dorsal horn and cortex neurons are responsible for pruritic cutaneous 5-HT stimulation.
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Report
(3 results)
Research Products
(41 results)
