To detect the affects of maternal exposure of OH-PCBs during pregnancy on metabolic pathway and disruption of thyroid hormones
Project/Area Number |
25860434
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Hokkaido University |
Principal Investigator |
ITO Sachiko 北海道大学, 環境健康科学研究教育センター, 特任助教 (90580936)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 環境疫学 / 予防医学 / 社会医学 / 疫学・予防医学 |
Outline of Final Research Achievements |
In a prospective birth cohort study, there was no statistical difference between any of the SNPs related to metabolic pathway and OH-PCB concentrations in maternal blood during pregnancy. We conducted multiple linear regression models to estimate the effects of maternal exposure to OH-PCBs on thyroid hormone statuses (TSH, FT4) of mother and infant. Statistical significant associations were found between maternal 4-OH-CB187 concentrations and maternal FT4, and maternalΣOH-PCB, 4-OH-CB187 and infant FT4 among only males. We measured the concentration of adiponectin and leptin in cord blood samples.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children2015
Author(s)
Mitsui T., Araki A., Imai A, Sato S., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K. Cho K., Morioka K., Kihsi R., Nonomura K
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Journal Title
PLOS One
Volume: 10(3)
Issue: 3
Pages: e0120636-e0120636
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children's Health2014
Author(s)
Araki A., Mitsui T., Miyashita C., Nakajima T., Naito H., Ito S., Sasaki S., Cho K., Ikeno T., Nonomura K., Kishi R.
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Journal Title
PLOS One
Volume: 9(10)
Issue: 10
Pages: e109039-e109039
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013.2013
Author(s)
Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
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Journal Title
Environmental Health and Preventive Medicine
Volume: 18
Issue: 6
Pages: 429-450
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of prenatal bisphenol A exposure on birth weight, sex hormone levels and mental and motor development2014
Author(s)
Minatoya M, Sasaki S, Nakajima S, Yamamoto J, Araki A, Ito S, Miyashita C, Matsumura T, Nonomura K, Mitsui T, Cho K, Kishi R.
Organizer
2014 Conference of International Society for Environmental Epidemiology Asia Chapter
Place of Presentation
Xinhua Hospital, Shanghai (China)
Year and Date
2014-11-30 – 2014-12-02
Related Report
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[Presentation] Perinatal PFAAs Exposure Cause Various Health Outcomes on Offspring Including Effects on Reproductive and Thyroid Hormones: The Hokkaido Study2014
Author(s)
Reiko Kishi, Atsuko Araki, Sachiko Itoh, Chihiro Miyashita, Houman Goudarzi, Sachiko Kobayashi, Seiko Sasaki, Ikuko Kashino, H Nakazawa, Tamie Nakajima, Takahiko Mitsui, Katsuya Nonomura
Organizer
PPTOX IV
Place of Presentation
Boston Marriott Long Wharf Hotel, Massachusetts (USA)
Year and Date
2014-10-26 – 2014-10-29
Related Report
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[Presentation] Effect of PFOS and PFOA exposure in utero on reproductive hormones levels at birth2014
Author(s)
Itoh S., Araki A., Miyashita C., Nakazawa H., Mitsui T., Cho K., Sasaki S., Ikeno T., Nonomura K., Kishi R.
Organizer
26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
Place of Presentation
Husky Union Building, the University of Washington, Seattle (USA)
Year and Date
2014-08-24 – 2014-08-28
Related Report
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[Presentation] Association between maternal exposure to di(2-ethylhexyl) phthalate and sex hormone levels in fetal blood2014
Author(s)
Araki A., Mitsui T., Miyashita C., Nakajima T., Nakazawa H., Sasaki S., Ikeno T., Cho K., Itoh S., Nonomura K., Kishi R.
Organizer
26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
Place of Presentation
Husky Union Building, the University of Washington, Seattle (USA)
Year and Date
2014-08-24 – 2014-08-28
Related Report
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[Presentation] The effects of perfluoroalkyl acids (PFAAs) exposure in utero on IGF2/H19 DNA methylation in cord blood2014
Author(s)
Kobayashi S., Azumi K., Sasaki S., Ishizuka M., Nakazawa H., Okada E., Kobayashi S., Goudarzi H., Itoh S., Miyashita C., Ikeno T., Araki A., Kishi R.
Organizer
26th Annual International Society for Environmental Epidemiology Conference
Place of Presentation
Husky Union Building, the University of Washington, Seattle (USA)
Year and Date
2014-08-24 – 2014-08-28
Related Report
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[Presentation] DEHPへの胎児期曝露による児の性ホルモン濃度への影響2014
Author(s)
荒木敦子, 三井貴彦, 宮下ちひろ, 那須民江, 伊藤佐智子, 佐々木成子, 長和俊, 池野多美子, 野々村克也, 岸玲子
Organizer
第84回 日本衛生学会学術総会
Place of Presentation
岡山コンベンションセンター(岡山県・岡山市)
Year and Date
2014-05-25 – 2014-05-27
Related Report
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[Presentation] The effects of hydroxylated PCBs in maternal serum on infant thyroid hormones2013
Author(s)
Itoh S., Kajiwara J., Miyashita C., Kobayashi S., Sasaki S., Ban S., Ikeno T., Araki A., Kishi R.
Organizer
Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
Place of Presentation
Congress Center Basel (スイス)
Related Report
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[Presentation] Maternal exposure to dehp and sex hormone levels in cord blood2013
Author(s)
Araki A., Mitsui T., Miyashita C., Tagawa M., Nakajima T., Sasaki S., Ikeno T., Itoh S., Okada E., Cho K., Nonomura K., Kishi R.
Organizer
DOHaD2013-8th World Congress on DOHaD
Place of Presentation
サンテック・シンガポール国際会議展示場(シンガポール)
Related Report
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