Epidemiological study on the association between serum adipocyte fatty acid-binding protein, fatty acid proportions and abnormal glucose metabolism.

• Project/Area Number: 25860439
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokushima
• Principal Investigator: HATA Akiko 徳島大学, 大学病院, 特任助教 (20570948)
• Research Collaborator: FUNAKI Makoto 徳島大学, 病院, 特任教授 (10467821)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脂肪酸結合蛋白質 / 疫学 / メタボリックシンドローム / 糖代謝異常 / コホート研究 / FABP4 / 脂肪酸分画 / 脂肪酸結合蛋白

Outline of Final Research Achievements

The aim of the present study is to investigate an association between serum concentration of adipocyte fatty acid-binding protein (FABP4) and incidence of glucose metabolism disorder (GMD) or metabolic syndrome (MetS) in Japanese male workers. A prospective occupational-based study has been conducted since 2008. Male workers aged 20 to 60 years were followed up for 6 years.
The age-adjusted incidence of GMD or MetS significantly increased with increasing tertile of serum FABP4 levels at baseline (P for trend<0.05). Multivariate-adjusted HR for the development of GMD tends to increase with increasing serum FABP4 levels. Moreover, in multivariate analyses, the HR of MetS was 3.39 [95% CI:1.44-7.96] in the highest tertile when compared with the lowest tertile.
Our findings suggest that increased serum concentration of FABP4 is a risk factor for the incidence of MetS in Japanese male workers. Measuring serum levels of FABP4 may be useful to predict an onset of MetS.

Research Products

• [Journal Article] Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers (2015)
  • Author(s): 1.Hata A, Yonemoto K, Shikama Y, Aki N, Kosugi C, Tamura A, Ichihara T, Minagawa T, Kuwamura Y, Misyoshi M, Nakao T, Funaki M.
  • Journal Title: PLoS ONE Volume: 10 Issue: 2 Pages: e0118373-e0118373
  • DOI: 10.1371/journal.pone.0118373
  • NAID: 120006872352
  • Peer Reviewed / Open Access
• [Presentation] Serum Fatty Acid Proportions Are Related to Development of Metabolic Syndrome in Japanese Male Workers (2015)
  • Author(s): Akiko Hata, Yosuke Shikama, Nanako Aki, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
  • Organizer: American Diabetes Association's 75th Scientific Sessions
  • Place of Presentation: Boston Convention and Exhibition Center（Boston, USA）
  • Year and Date: 2015-06-07
• [Presentation] 徳島県における全脂質中脂肪酸分画とメタボリックシンドローム発症との関連 (2015)
  • Author(s): 秦 明子、四釜 洋介、安藝 菜奈子、田村 綾子、市原 多香子、南川 貴子、桑村 由美、船木 真理
  • Organizer: 第58日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール(山口県下関市)
  • Year and Date: 2015-05-22
• [Presentation] 徳島県における血清脂肪細胞特異的脂肪酸結合蛋白質とメタボリックシンドローム発症との関連 (2014)
  • Author(s): 秦 明子、四釜 洋介、安藝 菜奈子、小杉 知里、小林 寛也、三好 雅士、中尾 隆之、田村 綾子、市原 多香子、南川 貴子、桑村 由美、松本 俊夫、船木 真理
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテルNCB(大阪府大阪市)
  • Year and Date: 2014-05-23
• [Presentation] Serum Adipocyte Fatty Acid-binding Protein Is Related to the Development of Metabolic Syndrome in Japanese Male Workers (2014)
  • Author(s): Akiko Hata,Yosuke Shikama, Nanako Aki, Chisato Kosugi, Hiroya Kobayashi, Masashi Miyoshi, Takayuki Nakao, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Toshio Matsumoto, Makoto Funaki
  • Organizer: American Diabetes Association's 74th Scientific Sessions
  • Place of Presentation: Moscone Center (San Francisco, USA)