| Project/Area Number |
25860439
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HATA Akiko 徳島大学, 大学病院, 特任助教 (20570948)
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| Research Collaborator |
FUNAKI Makoto 徳島大学, 病院, 特任教授 (10467821)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脂肪酸結合蛋白質 / 疫学 / メタボリックシンドローム / 糖代謝異常 / コホート研究 / FABP4 / 脂肪酸分画 / 脂肪酸結合蛋白 |
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| Outline of Final Research Achievements |
The aim of the present study is to investigate an association between serum concentration of adipocyte fatty acid-binding protein (FABP4) and incidence of glucose metabolism disorder (GMD) or metabolic syndrome (MetS) in Japanese male workers. A prospective occupational-based study has been conducted since 2008. Male workers aged 20 to 60 years were followed up for 6 years.
The age-adjusted incidence of GMD or MetS significantly increased with increasing tertile of serum FABP4 levels at baseline (P for trend<0.05). Multivariate-adjusted HR for the development of GMD tends to increase with increasing serum FABP4 levels. Moreover, in multivariate analyses, the HR of MetS was 3.39 [95% CI:1.44-7.96] in the highest tertile when compared with the lowest tertile.
Our findings suggest that increased serum concentration of FABP4 is a risk factor for the incidence of MetS in Japanese male workers. Measuring serum levels of FABP4 may be useful to predict an onset of MetS.
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