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A cross-sectional association of distal proximal gradient of skin temperature with blood pressure, glucose-fat metabolism, and sleep.

Research Project

Project/Area Number 25860447
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionNara Medical University

Principal Investigator

SAEKI KEIGO  奈良県立医科大学, 医学部, 講師 (60364056)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords予防医学 / サーカディアンリズム / 皮膚温 / 血圧 / 睡眠 / 夜間頻尿 / 室温 / 生体リズム / 肥満 / 疫学研究
Outline of Final Research Achievements

Previous studies suggested fluctuation of skin temperature as a potential indicator of internal biological rhythm because it shows mirror image of rectal temperature. In the present study, we assessed association between fluctuation of skin temperature and health problems among 590 elder participants in winter. Distal and proximal gradient (DPG) of skin temperature was significantly associated with nocturnal blood pressure decline and prevalence of nocturia. In addition, wrist temperature at evening (2h before bedtime) and initial night (2h after bedtime) was significantly associated with objectively measured sleep onset latency.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (39 results)

All 2016 2015 2014 2013 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Acknowledgement Compliant: 8 results) Presentation (20 results) (of which Int'l Joint Research: 2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Short-term effects of instruction in home heating on indoor temperature and blood pressure in elderly people: a randomized controlled trial.2015

    • Author(s)
      Saeki K, Obayashi K, Kurumatani N.
    • Journal Title

      J Hypertens

      Volume: 33 Issue: 11 Pages: 2338-2343

    • DOI

      10.1097/hjh.0000000000000729

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A warmer indoor environment in the evening and shorter sleep onset latency in winter: The HEIJO-KYO study.2015

    • Author(s)
      Saeki K, Obayashi K, Tone N, Kurumatani N.
    • Journal Title

      Physiol Behav.

      Volume: 149 Pages: 29-34

    • DOI

      10.1016/j.physbeh.2015.05.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Daytime cold exposure and salt intake based on nocturnal urinary sodium excretion: A cross-sectional analysis of the HEIJO-KYO study.2015

    • Author(s)
      Saeki K, Obayashi K, Tone N, Kurumatani N.
    • Journal Title

      Physiol Behav

      Volume: 152 Pages: 300-306

    • DOI

      10.1016/j.physbeh.2015.10.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 冬の室温と外気温のどちらが血圧と強く関連するか?2015

    • Author(s)
      佐伯圭吾、大林賢史、車谷典男
    • Journal Title

      血圧

      Volume: 22 Pages: 10-11

    • Related Report
      2014 Research-status Report
  • [Journal Article] Independent associations of exposure to evening light and nocturnal urinary melatonin excretion with diabetes in the elderly.2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N.
    • Journal Title

      Chronobiol Int

      Volume: 31 Issue: 3 Pages: 394-400

    • DOI

      10.3109/07420528.2013.864299

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between light exposure at night and nighttime blood pressure in the elderly independent of nocturnal urinary melatonin excretion2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N.
    • Journal Title

      Chronobiology interntional.

      Volume: 31 Issue: 6 Pages: 779-786

    • DOI

      10.3109/07420528.2014.900501

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of exposure to evening light on sleep initiation in the elderly: a longitudinal analysis for repeated measurements in home settings.2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N.
    • Journal Title

      Chronobiol Int.

      Volume: 31 Issue: 4 Pages: 461-7

    • DOI

      10.3109/07420528.2013.840647

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between light exposure at night and insomnia in the general elderly population: the HEIJO-KYO cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      Chronobiol Int

      Volume: 31 Issue: 9 Pages: 976-982

    • DOI

      10.3109/07420528.2014.937491

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between urinary 6-sulfatoxymelatonin excretion and arterial stiffness in the general elderly population: the HEIJO-KYO cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 99 Issue: 9 Pages: 3233-3239

    • DOI

      10.1210/jc.2014-1262

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relationship between melatonin secretion and nighttime blood pressure in elderly individuals with and without antihypertensive treatment: a cross-sectional study of the HEIJO-KYO cohort2014

    • Author(s)
      Obayashi K, Saeki K, Tone N, Kurumatani N.
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 10 Pages: 908-913

    • DOI

      10.1038/hr.2014.99

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The relationship between indoor, outdoor and ambient temperatures and morning BP surges from inter-seasonally repeated measurements2014

    • Author(s)
      Saeki K, Obayashi K, Iwamoto J, Tone N, Okamoto N, Tomioka K, Kurumatani N.
    • Journal Title

      J Hum Hypertens

      Volume: 28 Issue: 8 Pages: 482-488

    • DOI

      10.1038/jhh.2014.4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stronger association of indoor temperature than outdoor temperature with blood pressure in colder months2014

    • Author(s)
      Saeki K, Obayashi K, Iwamoto J, Tone N, Okamoto N, Tomioka, Kurumatani N.
    • Journal Title

      J hypertens

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Melatonin Secretion and Nocturia in Elderly Individuals: a Cross-Sectional Study of the HEIJO-KYO Cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      J Urol.

      Volume: 未定 Issue: 6 Pages: 1816-1821

    • DOI

      10.1016/j.juro.2013.12.043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between light exposure at night and nighttime blood pressure in the elderly independent of nocturnal urinary melatonin excretion.2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N.
    • Journal Title

      Chronobiol Int.

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exposure to light at night and risk of depression in the elderly.2013

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N.
    • Journal Title

      J Affect Disord.

      Volume: 151 Issue: 1 Pages: 331-6

    • DOI

      10.1016/j.jad.2013.06.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nocturnal urinary melatonin excretion is associated with non-dipper pattern in elderly hypertensives2013

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N.
    • Journal Title

      Hypertens Res

      Volume: 掲載確定 Issue: 8 Pages: 736-40

    • DOI

      10.1038/hr.2013.20

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Obesity and Indoor Cold Exposure: A Cross-Sectional Analysis of The HEIJO-KYO Cohort2016

    • Author(s)
      Keigo Saeki, Kenji Obayashi, and Norio Kurumatani.
    • Organizer
      ENDO
    • Place of Presentation
      ボストン
    • Year and Date
      2016-03-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Platelet count and indoor cold exposure: A cross-sectional analysis of the HEIJO-KYO study2016

    • Author(s)
      佐伯圭吾、大林賢史、車谷典男
    • Organizer
      日本疫学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Daytime cold exposure in winter and longer sleep time independent of daylength: A cross sectional analysis of HEIJO-KYO study2015

    • Author(s)
      佐伯圭吾、大林賢史、車谷典男
    • Organizer
      日本時間生物学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 就寝前後の手関節部皮膚温とアクチグラフで計測した睡眠の質との関連:高齢者大規模コホート研究(平城京スタディ)の横断解析2015

    • Author(s)
      佐伯圭吾、大林賢史、刀根庸浩、車谷典男
    • Organizer
      日本睡眠学会定期学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Higher Wrist Skin Temperature In Evening To Initial Night-time And Better Actigraphic Sleep Quality In Real Life: HEIJO-KYO Study2015

    • Author(s)
      Keigo Saeki, Kenji Obayashi, Nobuhiro Tone, and Norio Kurumatani
    • Organizer
      SLEEP
    • Place of Presentation
      シアトル
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distal-Proximal Gradient of Skin Temperatures and Nocturnal Blood Pressure Fall among 590 Elderly Individuals: A Cross-Sectional Study of the HEIJO-KYO Cohort2014

    • Author(s)
      佐伯圭吾、大林賢史、刀根庸浩、車谷典男
    • Organizer
      第21回日本時間生物学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 冬季の曝露温度と尿中ナトリウム排泄量の関連 -平城京スタディ ベースライン横断解析-2014

    • Author(s)
      佐伯圭吾 大林賢史 車谷典男
    • Organizer
      第73回 日本公衆衛生学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Association between cataract surgery and quality of objective sleep in the elderly: A cross-sectional study of The HEIJO-KYO cohort.2014

    • Author(s)
      Kimie Miyata, Tomo Nishi, Kenji Obayashi, Keigo Saeki, Nobuhiro Tone, Norio Kurumatani, Nahoko Ogata.
    • Organizer
      第28回 米国睡眠学会
    • Place of Presentation
      ミネアポリス
    • Year and Date
      2014-05-31 – 2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Accuracy for ambulatory eye-level measurement of light at night in home settings: Cross-sectional association with subjective and actigraphic sleep quality in the HEIJO-KYO Cohort.2014

    • Author(s)
      Nobuhiro Tone, Kenji Obayashi, Keigo Saeki, Shinji Suzuki, Syoichi Takamiya, Tomo Nishi, Kimie Miyata, Norio Kurumatani.
    • Organizer
      第28回 米国睡眠学会2014
    • Place of Presentation
      ミネアポリス
    • Year and Date
      2014-05-31 – 2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Exposure to light at night and risk of insomnia in general elderly population: cross-sectional association in home settings in the HEIJO-KYO cohort.2014

    • Author(s)
      Kenji Obayashi, Keigo Saeki, Nobuhiro Tone, Kimie Miyata, Norio Kurumatani.
    • Organizer
      第28回 米国睡眠学会2014
    • Place of Presentation
      ミネアポリス
    • Year and Date
      2014-05-31 – 2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Association Of Low Evening Indoor Temperature With Prolonged Sleep Onset Latency:Baseline analysis of the Heijo-kyo Cohort Study2014

    • Author(s)
      Keigo Saeki, Kenji Obayashi, Nobuiro Tone, Tomo Nishi, Kimie Miyata, Naoto Otaki, Maiko Kitgawa, Syoichi Takamiya, Norio Kurumatani.
    • Organizer
      第28回米国睡眠学会
    • Place of Presentation
      ミネアポリス
    • Related Report
      2013 Research-status Report
  • [Presentation] 就寝前室温低下と高齢者の入眠潜時延長についての縦断的関連 平城京スタディ2014

    • Author(s)
      佐伯圭吾 大林賢史 刀根庸浩 車谷典男
    • Organizer
      第24回 日本疫学会総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Independent influences of Actigraphic Sleep profile and Exposed temperature on Nocturnal BP fall among the elderly Cross-sectional analysis of HEIJO-KYO Cohort study.2013

    • Author(s)
      Keigo Saeki, Kenji Obayashi, Kimie Miyata, Nobuhiro Tone, Junko Iwamoto, Nozomi Okamoto, Kimiko Tomioka, Norio Kurumatani.
    • Organizer
      第27回米国睡眠学会
    • Place of Presentation
      ボルチモア
    • Related Report
      2013 Research-status Report
  • [Presentation] Exposure to Evening Light is associated with Actigraphic Slpeep-Onset Latency in the Elderly: A cross-sectional analysis of Heijo-Kyo Study.2013

    • Author(s)
      Kenji Obayashi, Keigo Saeki, Kimie Miyata, Nobuhiro Tone, Junko Iwamoto, Nozomi Okamoto, Kimiko Tomioka, Norio Kurumatani.
    • Organizer
      第27回米国睡眠学会
    • Place of Presentation
      ボルチモア
    • Related Report
      2013 Research-status Report
  • [Presentation] The Impact of Retinal Thickness on Actigraphic Sleep Quality in the Elderly: A Cross-sectional Analysis of the HEIJO-KYO Study.2013

    • Author(s)
      Kimie Miyata, Kenji Obayashi, Keigo Saeki, Nobuhiro Tone, Junko Iwamoto, Nozomi Okamoto, Kimiko Tomioka,Norio Kurumatani.
    • Organizer
      第27回米国睡眠学会
    • Place of Presentation
      ボルチモア
    • Related Report
      2013 Research-status Report
  • [Presentation] Association of indoor temperature with circadian rhythm of ambulatory blood pressure: A Cross-sectional Study of the HEIJO-KYO Cohort2013

    • Author(s)
      佐伯圭吾、大林賢史、刀根庸浩、岩本淳子、冨岡公子、岡本希、車谷典男
    • Organizer
      第20回 時間生物学会2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Exposure to Light at Night and Impaired Sleep Quality in the Elderly: A Cross-Sectional Study of the HEIJO-KYO Cohort2013

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、岩本淳子、冨岡公子、岡本希、車谷典男
    • Organizer
      第20回 時間生物学会2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Association of Cataract Surgery with Objective Sleep Quality in the Elderly: A Cross-Sectional Study of the HEIJO-KYO Cohort2013

    • Author(s)
      宮田季美恵、大林賢史、佐伯圭吾、刀根庸浩、車谷典男、緒方奈保子
    • Organizer
      第20回 時間生物学会2013年
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 室温・外気温および曝露温度と自由行動下血圧指標との 関連 住環境に関する大規模疫学調査(平城京スタディ)の横断解析2013

    • Author(s)
      佐伯圭吾、大林賢史、刀根庸浩
    • Organizer
      日本建築学会学術大会2013
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 日中・夜間光曝露量とメラトニン分泌および肥満・ 脂質異常症との関連―住環境に関する大規模疫学調査(平城京スタディ)の横断解析―2013

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩
    • Organizer
      日本建築学会学術大会2013
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Remarks] 平城京スタディ

    • URL

      http://www.naramed-u.ac.jp/~che/study/heijo-kyo/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 平城京スタディ

    • URL

      http://www.naramed-u.ac.jp/~che/study/heijo-kyo/index.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 生体リズムの測定方法および生体リズム測定装置2013

    • Inventor(s)
      刀根庸浩、佐伯圭吾、大林賢史、高宮祥一
    • Industrial Property Rights Holder
      刀根庸浩、佐伯圭吾、大林賢史、高宮祥一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-31
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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