| Project/Area Number |
25860449
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Research Collaborator |
MUTO TAKASHI
UMESAWA MITSUMASA
YAMAGISHI KAZUMASA
KITAMURA AKIHIKO
ISO HIROASU
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酸化ストレス / 8-OHdG / 循環器疾患 / 発症 / 一般地域住民 / コホート研究 / nested case-control / 24時間畜尿検査 / 尿中バイオマーカー / 脳卒中 / 虚血性心疾患 / 死亡 / 地域住民 / HPLC / 発症調査 |
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| Outline of Final Research Achievements |
Oxidative stress is a risk factor of atherosclerosis and diabetes. However, it is unknown whether oxidative stress raises the risk of ischemic cardiovascular diseases. So, we conducted this study to evaluate the relationship of oxidative stress to ischemic cardiovascular disease among general population in Japan.
To accomplish this goal, we made comparison the patient group and control group (which is not patient of ischemic cardiovascular diseases) about their level of urinary oxidative stress marker (these urine samples have been collected prior to the onset of disease).
The results, the oxidative stress marker level of patient group was higher than control group among women, but not men. These results indicated that higher oxidative stress may associated with future onset of ischemic cardiovascular diseases among women. It is unknown that the reason for the difference in the relationship by gender, which is the next theme in this field.
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