A five-year longitudinal study for planning preventive procedures of fracture based on bone mass and bone quality

• Project/Area Number: 25860452
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kinki University
• Principal Investigator: FUJITA Yuki 近畿大学, 医学部, 講師 (10330797)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 骨折 / 骨量 / 骨質 / 骨粗鬆症 / コホート研究 / 男性

Outline of Final Research Achievements

Subjects with osteoporotic fracture were higher level of serum pentosidine and lower level of serum endogenous secretory receptorfor advanced glycation endproducts (esRAGE) than subjects without osteoporotic fracture among subjects with low bone mineral density. There was an association between diabetes mellitus or renal dysfunction and high level of serum pentosidine. Thus, serum pentosidine or esRAGE may be a predictor of osteoporotic fracture.