| Project/Area Number |
25860457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
YAMAKAGE Hajime 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究員 (40598900)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAHARA Noriko 独立行政法人国立病院機構, 京都医療センター臨床研究センター糖尿病研究部, 臨床代謝栄養研究室長 (80373512)
KOTANI Kazuhiko 自治医科大学, 臨床検査医学, 准教授 (60335510)
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| Research Collaborator |
MORISAKI Takayuki 国立循環器病研究センター研究所, 分子生物学部, 部長
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 臨床 / 肥満 / メタボリックシンドローム / 心腎連関 / シスタチンC / 動脈硬化 / 脂肪酸 / シスタチンＣ / 脂質代謝異常 |
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| Outline of Final Research Achievements |
In this study, we established two multicenter prospective cohorts of JOMS and J-DOS with 1334 obesity and/or diabetes patients. A total of 425 obese outpatients who were enrolled in a multicenter cohort JOMS, 300 (about 80%) of which were followed into the fifth year. During the study period, 29 caridio-vascular events occurred and CVD cumulative incidence rate was 8%. In the Cox multivariate analysis of adjusted models for traditional risk factors, low HDL-C was a significant factor for the incidence of events in men and SAA-LDL was in women.
In J-DOS, in 468 diabetic patients, serum cystatin C (S-CysC) and eGFRcys had significantly stronger correlations with the number of components of metabolic syndrome, and the 10-year Framingham CHD risk than serum creatinine (Cre), eGFRcre, and UACR. The ROC curves to distinguish the high-risk patients for CHD revealed significantly larger areas under the curve of S-CysC and eGFRcys than those of Cre, UACR, and eGFRcre.
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