A cohort study on an optimal biomarker of lipid profiles and effective treatment of dyslipidemia for the prevention of the development of cardio-renal connection
Project/Area Number |
25860457
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
Principal Investigator |
YAMAKAGE Hajime 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究員 (40598900)
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Co-Investigator(Renkei-kenkyūsha) |
ASAHARA Noriko 独立行政法人国立病院機構, 京都医療センター臨床研究センター糖尿病研究部, 臨床代謝栄養研究室長 (80373512)
KOTANI Kazuhiko 自治医科大学, 臨床検査医学, 准教授 (60335510)
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Research Collaborator |
MORISAKI Takayuki 国立循環器病研究センター研究所, 分子生物学部, 部長
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 臨床 / 肥満 / メタボリックシンドローム / 心腎連関 / シスタチンC / 動脈硬化 / 脂肪酸 / シスタチンC / 脂質代謝異常 |
Outline of Final Research Achievements |
In this study, we established two multicenter prospective cohorts of JOMS and J-DOS with 1334 obesity and/or diabetes patients. A total of 425 obese outpatients who were enrolled in a multicenter cohort JOMS, 300 (about 80%) of which were followed into the fifth year. During the study period, 29 caridio-vascular events occurred and CVD cumulative incidence rate was 8%. In the Cox multivariate analysis of adjusted models for traditional risk factors, low HDL-C was a significant factor for the incidence of events in men and SAA-LDL was in women. In J-DOS, in 468 diabetic patients, serum cystatin C (S-CysC) and eGFRcys had significantly stronger correlations with the number of components of metabolic syndrome, and the 10-year Framingham CHD risk than serum creatinine (Cre), eGFRcre, and UACR. The ROC curves to distinguish the high-risk patients for CHD revealed significantly larger areas under the curve of S-CysC and eGFRcys than those of Cre, UACR, and eGFRcre.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Comparison of cystatin C- and creatinine-based estimated glomerular filtration rate to predict coronary heart disease risk in Japanese patients with obesity and diabetes2015
Author(s)
Ito R, Yamakage H, Kotani K, Wada H, Otani S, Yonezawa K, Ogo A, Okajima T, Adachi M, Araki R, Yoshida K, Saito M, Nagaoka T, Toyonaga T, Tanaka T, Yamada T, Ota I, Oishi M, Miyanaga F, Shimatsu A, Satoh-Asahara N, The Japan Diabetes and Obesity Study (J-DOS) Group.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 2
Pages: 201-207
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein.2014
Author(s)
Komiyama M, Wada H, Ura S, Yamakage H, Satoh-Asahara N, Shimada S, Akao M, Koyama H, Kono K, Shimatsu A, Takahashi Y, Hasegawa K.
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Journal Title
Heart Vessels.
Volume: online
Issue: 6
Pages: 734-739
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia.2014
Author(s)
Ito R, Satoh-Asahara N, Yamakage H, Sasaki Y, Odori S, Kono S, Wada H, Suganami S, Ogawa Y, Hasegawa K, Shimatsu A
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Journal Title
J Atheroscler Thromb
Volume: 21
Pages: 248-260
NAID
Related Report
Peer Reviewed
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation of current smokers.2013
Author(s)
Takanabe-Mori R, Ono K, Wada H, Takaya T, Ura S, Yamakage H, Satoh-Asahara N, Shimatsu A, Takahashi Y, Fujita M, Fujita Y, Sawamura T, Hasegawa K
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Journal Title
J Atheroscler Thromb
Volume: 20
Pages: 585-590
NAID
Related Report
Peer Reviewed
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[Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity.2015
Author(s)
Satoh-Asahara N, Matsuo Y, Tanaka M, Sasaki Y, Yamakage H, Muranaka K, Ikai I, Hata H, Shimatsu A, Inoue M, Tae-Hwa Chun.
Organizer
2015 Keystone Symposia Conference
Place of Presentation
Kanada, British Columbia,Wistler
Year and Date
2015-03-22 – 2015-03-27
Related Report
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[Presentation] Effect of Sitagliptin and Vildagliptin, Dipeptidyl Peptidase-4 Inhibitors, on M1/M2-like Phenotypes of Peripheral Blood Monocytes and Arterial Stiffness in Type 2 Diabetic Patients.2014
Author(s)
Noriko Satoh-Asahara, Masashi Tanaka, Yoshiyuki Matsuo, Hajime Yamakage, Kazuya Muranaka, Yousuke Sasaki, Shinji Odori, Shigeo Kono, Akira Shimatsu
Organizer
9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
Place of Presentation
京都
Year and Date
2014-09-12 – 2014-09-14
Related Report
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[Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity.2014
Author(s)
Yoshiyuki Matsuo, Masashi Tanaka, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Iwao Ikai, Hiroaki Hata, Akira Shimatsu, Mayumi Inoue, Tae-Hwa Chun, Noriko Satoh-Asahara
Organizer
9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
Place of Presentation
京都
Year and Date
2014-09-12 – 2014-09-14
Related Report
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[Presentation] Influence of Post-smoking Cessation Weight Gain on Serum α1-antitrypsin-low Density Lipoprotein Levels.2013
Author(s)
Komiyama M, Wada H, Ura S, Yamakage H, Satoh-Asahara N, Shimatsu A, Koyama H, Kono K, Takahashi Y, Hasegawa K
Organizer
American Heart Association Scientific Sessions
Place of Presentation
USA, Texas, Dallas
Related Report
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[Presentation] Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, improves the unfavorable M1/M2-like phenotypes of peripheral blood monocytes in Japanese type 2 diabetic patients.2013
Author(s)
Noriko Satoh-Asahara, Shinji Odori, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Reiko Nakagawachi, Shigeo Kono, Hiromichi Wada, Koji Hasegawa, Akira Shimatsu
Organizer
73rd Scientific Sessions, American Diabetes Association
Place of Presentation
Chicago
Related Report
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