| Project/Area Number |
25860471
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アスベスト / 腫瘍免疫 / 制御性T細胞 / アポトーシス / 転写因子 / FoxP3 / GATA1 |
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| Outline of Final Research Achievements |
We studied effect of long-term exposure to asbestos with MT-2 cells as a regulatory T cell model. It was revealed that long-term exposure to asbestos reduced transcription factors, FoxO1 and FoxP3, in MT-2 cells. Furthermore, FoxO1 target molecules were suppressed by long-term exposure to asbestos. Expression of recombinant FoxP3 enhanced sensitivity to asbestos. These results suggest that exposure to asbestos modifies regulatory T cell function through the inactivation of FoxO1 and FoxP3. These are important to elucidate effect of asbestos on regulatory T cells and tumor immunity.
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