Epidemiology of Adverse Drug Event in intensive care unit (ICU) and neonatal ICU (NICU)

• Project/Area Number: 25860484
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical and hospital managemen
• Research Institution: Hyogo Medical University
• Principal Investigator: OHTA Yoshinori 兵庫医科大学, 医学部, 講師 (10516404)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 臨床疫学研究 / 医療の質 / 薬剤性有害事象 / 集中治療 / 薬害性有害事象

Outline of Final Research Achievements

We evaluated the epidemiology of Adverse Drug Events (ADEs) in the ICUs and NICUs as well as their impact on morbidity and mortality. We analyzed the data of the Japan Adverse Drug Events (JADE) study, a multicenter cohort study, and we used the length of ICU stay as morbidity. The incidents of ADEs in ICUs was 30.6 ADEs per 1000 patient-days and 21.6 ADEs per 100 admission, and in NICUs was 10.9 ADEs per 1000 patient-days and 27.2 ADEs per 100 admission. Excluding 38 deaths within 3 days after admission,12 patients (17%) died among the 70 patients who had at least one ADE during their ICU stay and 23 (7%) died among 351 without an ADE (p=0.003). The median ICU stay of patients with at least one ADE was 13 days, while it was only 2 days in the remainder (p<0.0001) . ADEs were especially important in ICUs and NICUs.

Research Products

• [Journal Article] Epidemiology of adverse events and medical errors in the care of cardiology patients. (2016)
  • Author(s): Ohta Y, Miki I, Kimura T, Abe M, Sakuma M, Koike K, Morimoto T.
  • Journal Title: J Patient Saf Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study. (2014)
  • Author(s): Ohta Y, Sakuma M, Koike K, Bates DW, Morimoto T.
  • Journal Title: Int J Qual Health Care Volume: 26 Issue: 6 Pages: 573-578
  • DOI: 10.1093/intqhc/mzu081
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adverse drug events and medication errors in Japanese pediatric inpatients: A retrospective cohort study. (2014)
  • Author(s): Sakuma Mio,Ida H, Nakamura T, Ohta Y, Yamamoto K, Seki S, Hiroi K, Kikuchi K, Nakayama K, Bates DW, Morimoto T
  • Journal Title: BMJ Qual Saf Volume: 印刷中 Issue: 10 Pages: 830-837
  • DOI: 10.1136/bmjqs-2013-002658
  • Peer Reviewed
• [Presentation] Epidemiology of medical errors among inpatients in Japan: The JET Study. (2015)
  • Author(s): Morimoto T, Ohta Y, Sakuma M, Bates DW.
  • Organizer: 32nd International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Doha, Qatar
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] The Epidemiology of adverse events in ICU patients in Japan: The JET Study. (2015)
  • Author(s): Ohta Y, Sakuma M, Bates DW, Morimoto T.
  • Organizer: 32nd International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Doha, Qatar
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] ICUにおける薬剤性有害事象の疫学研究 (2015)
  • Author(s): 太田好紀，作間未織，David W Bates，森本剛．
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] The epidemiology of operation related medical errors in inpatients in Japan: the JET Study. (2015)
  • Author(s): Ohta Y, Sakuma M, Bates DW, Morimoto T.
  • Organizer: 35th International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2015-03-17
• [Presentation] Incidence and nature of injuries due to medical care in Japan: the JET Study. (2014)
  • Author(s): Morimoto T, Sakuma M, Ohta Y, Bates DW.
  • Organizer: 31th International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-10-07
• [Presentation] The implementation of decision support system for reducing adverse drug events and medication errors in Japanese inpatients: the JADE Study. (2014)
  • Author(s): Sakuma M, Ohta Y, Bates DW, Morimoto T.
  • Organizer: 31th International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-10-06
• [Presentation] The epidemiology of operation related adverse events in inpatients: the JET Study. (2014)
  • Author(s): Ohta Y, Sakuma M, Bates DW, Morimoto T.
  • Organizer: 31th International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-10-06
• [Presentation] The epidemiology of medication errors in intensive care units in Japan: the JADE Study.
  • Author(s): Ohta Yoshinori
  • Organizer: 30th International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Edinburgh, UK
• [Presentation] The epidemiology of medication errors in the neonatal intensive care units in Japan: the JADE Study.
  • Author(s): Sakuma Mio
  • Organizer: 30th International Conference of the International Society for Quality in Health Care
  • Place of Presentation: Edinburgh, UK