| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We investigated the morphology and antibody reactivity in the thymus and Hassall’s corpuscles obtained from individuals containing mother and daughters, abused children, persons with ectopic thymus. Results indicated that the thymuses from intra-thyroidal and cervical ectopic thymuses contained Hassall’s corpuscles and the morphology of Hassall’s corpuscles resemble to that in the normal positioned thymuses. And we also indicate that morphology of Hassall’s corpuscles may be hereditary and the number of Hassall’s corpuscles increase in medulla of the thymus from children who died due to abuse or accident in the situations of increasing steroid hormone and in hormone treatment. Using immunohistochemical study we showed that Hassall’s corpuscles work as lymphangiogenic and/or angiogenic factor source. Hassall’s corpuscles might have protective system to avoid the attack by T cells. That indicate that the thymus are useful organ to estimate stress situation in practices.
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