| Project/Area Number |
25860491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Mie University |
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Principal Investigator |
Shuji KOZAWA 三重大学, 医学(系)研究科(研究院), 講師 (20379944)
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| Research Collaborator |
IKEMATSU KAZUYA 長崎大学, 医歯(薬)学総合研究科, 教授 (80332857)
NATA MASAYUKI 三重大学, 医学系研究科, 教授 (70241627)
IKEMURA MAYUMI 三重大学, 医学系研究科, 助教 (30515490)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 突然死 / マイクロアレイ / カスケード解析 / アルコール使用障害 / アルコール性臓器障害 / 不整脈 / pathway解析 / GeneOntology(GO)解析 / GeneOntology（GO）解析 |
|---|
| Outline of Final Research Achievements |
It is suggested that fatal arrhythmia is linked to long-term excessive alcohol use, and intracellular signaling pathways are believed to be involved in the mechanism. In the present study, using a microarray technique, a comprehensive analysis of gene expression profiles of cardiomyocytes was performed in a mouse model of chronic alcohol use. The results showed differing gene profiles in the acute and withdrawal phases, which suggested that activation of the JAK/STAT pathway and the cytokine-mediated inflammatory response may be occurring in the acute phase, while persistence of STAT3 and STAT6 activity and cell proliferation, i.e., remodeling, may be occurring in the withdrawal phase.
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