| Project/Area Number |
25860493
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
KATADA Ryuichi 大阪大学, 医学(系)研究科(研究院), 講師 (00423757)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルコール医学 / アクアポリン４ / 脳浮腫 / アストロサイト / ナトリウムチャンネル / アルコール / ナトリウム |
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| Outline of Final Research Achievements |
It is well known that ethanol has the bad effect on traumatic brain injury, which is due to the increase of aquaporin-4 (AQP4) expression. AQP4 has the interaction between ion channel (sodium channel). In this study, to elucidate the effect of sodium ion and ethanol on brain edema, rat primary astrocytes were incubated in hypo- or hyper-sodium and ethanol condition. Hypo-sodium increased AQP4 expression, however, siNKCC1 inhibited that AQP4 increasing. From these findings, AQP4 expression, which is related to sodium ion-induced brain edema, may be related to changing between AQP4 and sodium channel.
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