| Project/Area Number |
25860497
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
JO Michiko 富山大学, 和漢医薬学総合研究所, 助教 (80432110)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 五苓散 / アクアポリン / 浮腫 / 糖尿病 / アクアポリンタンパク質 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the mechanisms of the effects of goreisan, a Kampo formula, on edema in animal models of type 2 diabetes. The changes in urinary osmolality, water intake and the AQPs expression by goreisan-treatment in animal models of type 2 diabetes suggest that AQPs expression is associated with the effects of goreisan on modulation of water balance without causing renal dysfunction.
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