| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
This grant could give us two results. One of the result is that Japanese kampo medicine, ‘Go-sha-jinki-Gan’, prevented insulin resistance in skeletal muscle of aging model, SAMP8. These data also expressed that sarcopenia was occurred in aging skeletal muscle and Go-sha-jinki-Gan could stop to accelerate sarcopenia via improving skeletal muscle insulin/IGF1 signaling. Another of the result is low carbohydrate diet could initiate to make brown adipose tissue hyper-function and white adipose tissue ‘browning’ in terms of ‘food oriented medicine’. Low carbohydrate diet upregulated energy expenditure in aging model, SAMP8 via fat oriented energy utility but not sugar oriented energy utility. However, low carbohydrate diet up to aging was deteriorated skeletal muscle atrophy.
These result were the first evidence and the former was accepted to ‘Phytomedicine’ Journal in 2015.
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