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Epidemiological study of frontotemoral lobar degeneration

Research Project

Project/Area Number 25860500
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionTottori University

Principal Investigator

ADACHI Tadashi  鳥取大学, 医学部, 助教 (50555711)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords前頭側頭葉変性症 / 認知症 / 前頭側頭型認知症 / 疫学 / 病理
Outline of Final Research Achievements

Frontotemporal lobar degeneration (FTLD) is an important cause of early onset dementia. We conducted community based epidemiological survey of FTLD. In this survey, 66 patients were diagnosed with FTLD. Based on these results, the prevalence of FTLD in Japan was estimated to be 9.5 per 100,000 individuals. Follow up study of these patients for 4 years, 31 patients could not followed, 18 patients were followed, and 17 patients were died (follow up ratio was 54.7%). Mean survival of who died all patients during 4 years and behavior variant frontotemporal dementia patients were 7.3 and 5.6 years, respectively. This study could help to know the current state of treatment and care of FTLD patients.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Autopsy case of spinocerebellar ataxia type 31 with severe dementia at the terminal stage2015

    • Author(s)
      Adachi T, Kitayama M, Nakano T, Adachi Y, Kato S, Nakashima K
    • Journal Title

      Neuropathology

      Volume: 未定 Issue: 3 Pages: 273-279

    • DOI

      10.1111/neup.12184

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Alpha-synuclein accumulation in a patient with Auerbach's plexus of pure autonomic failure2014

    • Author(s)
      Kurashiki-Osaka, Adachi T, Nakayasu H, Nakashima K
    • Journal Title

      Intern Med

      Volume: 53 Pages: 2261-2261

    • NAID

      130004694528

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【認知症診療最前線】 嗜銀顆粒性認知症の診断2014

    • Author(s)
      足立 正, 齊藤 祐子, 中島 健二, 村山 繁雄
    • Journal Title

      Dementia Japan

      Volume: 28 Pages: 182-188

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Autopsy-confirmed progressive supranuclear palsy with decreased uptake of metaiodobenzylguanidine2013

    • Author(s)
      Adachi T, Kitayama M, Wada-Isoe K, Nakano T, Nakashima K
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 115(8) Pages: 1555-1557

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 繰り返す視神経炎後に大脳脳幹病変を呈した抗MOG抗体陽性脱髄疾患の1例2014

    • Author(s)
      足立正,安井建一,伊藤悟,渡辺保裕,古和久典,中島健二
    • Organizer
      第97回日本神経学会中国・四国地方会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 前頭側頭葉変性症の地域疫学調査2014

    • Author(s)
      足立正,田尻佑喜,和田健二,中島健二
    • Organizer
      第33回日本認知症学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] CSF1R新規変異R579Wを伴うhereditary diffuse leukoencephalopathy with spheroids兄妹剖検例2014

    • Author(s)
      足立正、宮田元、中野俊也、足立芳樹、加藤信介、中島健二
    • Organizer
      第55回日本神経病理学会総会
    • Place of Presentation
      学術総合センター(東京都)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] CSF1R新規変異R579Wを伴うHereditary diffuse leukoencephalopathy with spheroids 兄妹剖検例2013

    • Author(s)
      足立正, 和田健二, 足立芳樹, 青山泰明, 粟木悦子, 加藤信介, 古和久典, 中島健二
    • Organizer
      第94回日本神経学会中国・四国地方会
    • Place of Presentation
      松山市総合コミュニティーセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 嗜銀顆粒性認知症の診断2013

    • Author(s)
      足立正、齊藤祐子、中島健二、村山繁雄
    • Organizer
      第32回日本認知症学会総会シンポジウム
    • Place of Presentation
      松本市キッセイ文化ホール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] パーキンソン病の長男を持つ進行性核上性麻痺の1剖検例2013

    • Author(s)
      足立正, 北山通朗, 中野俊也, 渡辺保裕, 加藤信介, 中島健二
    • Organizer
      第95回日本神経学会中国・四国地方会
    • Place of Presentation
      米子市文化ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] Hereditary diffuse leukoencephalopathy with spheroids 兄妹剖検例2013

    • Author(s)
      足立正、宮田元、中野俊也、足立芳樹、加藤信介、中島健二
    • Organizer
      第4回日本神経病理学会中国・四国地方会
    • Place of Presentation
      愛媛県東温市志津川 愛媛大学医学部
    • Related Report
      2013 Research-status Report
  • [Book] 嗜銀顆粒性認知症.別冊日本臨床 神経症候群第2版2014

    • Author(s)
      村山繁雄,齊藤祐子,足立正
    • Total Pages
      903
    • Publisher
      日本臨床
    • Related Report
      2013 Research-status Report
  • [Book] Huntington disease-like syndromes(HDL).別冊日本臨床 神経症候群第2版2014

    • Author(s)
      足立正,中島健二
    • Total Pages
      903
    • Publisher
      日本臨床
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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