Application to cancer immunotherapy of natural compounds regulating macrophage activation

• Project/Area Number: 25860501
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kumamoto University
• Principal Investigator: Fujiwara Yukio 熊本大学, 大学院生命科学研究部, 講師 (70452886)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 代替医療 / ガン / マクロファージ / 天然化合物 / STAT3 / ガン治療 / 骨髄由来免疫抑制細胞

Outline of Final Research Achievements

It is well known that tumor-associated macrophages play an important role in tumor progression. In this study, we identified several natural compounds (corosolic acid, oleanolic acid and soyasapogenol etc.) as candidate compounds regulating macrophage activation and those compounds suppressed tumor proliferation under co-culture with macrophages and tumor cells. Furthermore, oral administration of those compounds significantly suppressed both tumor development and metastasis in a tumor-bearing mice. Therefore, these compounds may be potentially new tool for tumor prevention and therapy.

Research Products

• [Int'l Joint Research] Faculty of Pharmacy, Tanta University(Egypt)
• [Journal Article] Two new bicyclic sulfoxides from Welsh onion (2016)
  • Author(s): Nohara, Toshihiro; Fujiwara, Yukio; Ikeda, Tsuyoshi; Murakami, Kotaro; Ono, Masateru; El-Aasr, Mona; Nakano, Daisuke; Kinjo, Junei
  • Journal Title: Journal of Natural Medicines Volume Volume: 70 (2) Issue: 2 Pages: 260-265
  • DOI: 10.1007/s11418-015-0947-z
  • NAID: 40020758269
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products (2016)
  • Author(s): Nakashima, Keisuke; Miyashita, Hiroyuki; Yoshimitsu, Hitoshi; Fujiwara, Yukio; Nagai, Ryoji; Ikeda, Tsuyoshi
  • Journal Title: Journal of Natural Medicines Volume Volume: 70 (2) Issue: 2 Pages: 290-295
  • DOI: 10.1007/s11418-015-0962-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Non-invasive measurement of skin autofluorescence to evaluate diabetic complications (2016)
  • Author(s): Yamanaka M, Matsumura T, Ohno R, Fujiwara Y, Shinagawa M, Sugawa H, Hatano K, Shirakawa J, Kinoshita H, Ito K, Sakata N, Araki E, Nagai R
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 58 Issue: 2 Pages: 135-140
  • DOI: 10.3164/jcbn.15-132
  • NAID: 130005132521
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage. (2015)
  • Author(s): Takamoto H, Eguchi K, Kawabata T, Fujiwara Y, Takeya M, Tsukamoto S.
  • Journal Title: Bioscience, Biotechnology Biochemistry Volume: 79 Issue: 8 Pages: 1315-1319
  • DOI: 10.1080/09168451.2015.1023247
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury. (2015)
  • Author(s): Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T.
  • Journal Title: PLoS One. Volume: 10 Issue: 6 Pages: e0130248-e0130248
  • DOI: 10.1371/journal.pone.0130248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma. (2015)
  • Author(s): Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
  • Journal Title: Cancer Immunol Res. Volume: 3 Issue: 12 Pages: 1356-1363
  • DOI: 10.1158/2326-6066.cir-14-0180
  • Peer Reviewed / Open Access
• [Journal Article] Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. (2015)
  • Author(s): Eguchi K, Kato H, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 25 Issue: 22 Pages: 5389-5392
  • DOI: 10.1016/j.bmcl.2015.09.024
  • NAID: 120006897982
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Saponins, Esculeosides B-1 and B-2, in Tomato Juice and Sapogenol, Esculeogenin B₁ (2015)
  • Author(s): Nohara, Toshihiro; Fujiwara, Yukio; Zhou, Jian-Rong; Urata, Jun; Ikeda, Tsuyoshi; Murakami, Kotaro; El-Aasr, Mona; Ono, Masateru
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 10 Pages: 848-850
  • DOI: 10.1248/cpb.c15-00449
  • NAID: 130005100922
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype (2015)
  • Author(s): Fujiwara, Yukio; Shiraishi, Daisuke; Yoshitomi, Makiko; Ikeda, Tsuyoshi; Mizuta, Hiroshi; Takeya, Motohiro; Komohara, Yoshihiro
  • Journal Title: Journal of Functional Foods Volume: 19 A Pages: 594-605
  • DOI: 10.1016/j.jff.2015.09.055
  • Peer Reviewed / Open Access
• [Journal Article] Cyclic Sulfoxides-Garlicnins K₁, K₂, and H₁-Extracted from <i>Allium sativum</i> (2015)
  • Author(s): Nohara T, Fujiwara Y, Komota Y, Kondo Y, Saku T, Yamaguchi K, Komohara Y, Takeya M
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 2 Pages: 117-121
  • DOI: 10.1248/cpb.c14-00538
  • NAID: 130004803765
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses. (2014)
  • Author(s): Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
  • Journal Title: Sci. Rep. Volume: (印刷中) Issue: 1 Pages: 4680-4680
  • DOI: 10.1038/srep04680
  • NAID: 120005649608
  • Peer Reviewed / Open Access
• [Journal Article] Acyclic Sulfides, Garlicnins L-1–L-4, E, and F, from <i>Allium sativum</i> (2014)
  • Author(s): Toshihiro Nohara, Yukio Fujiwara, Tsuyoshi Ikeda, Koki Yamaguchi, Hideyuki Manabe, Kotaro Murakami, Masateru Ono, Daisuke Nakano, Junei Kinjo
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 62 Issue: 5 Pages: 477-482
  • DOI: 10.1248/cpb.c14-00003
  • NAID: 130004053793
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] Conversion of Tomato Saponins to Pregnane Derivatives (2014)
  • Author(s): Toshihiro Nohara, Hideyuki Manabe, Yukio Fujiwara, Tsuyoshi Ikeda, Masateru Ono, Kotaro Murakami, Daisuke Nakano, Junei Kinjo, Tetsuya Kajimoto
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 62 Issue: 5 Pages: 483-487
  • DOI: 10.1248/cpb.c14-00004
  • NAID: 130004053795
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids, from the Indonesian marine sponges, Acanthostrongylophora ingens. (2014)
  • Author(s): A. H. El-Desoky, H. Kato, K. Eguchi, T. Kawabata, Y. Fujiwara, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, M. Takeya, H. Yokosawa, S. Tsukamoto
  • Journal Title: J. Nat. Prod. Volume: 77 Issue: 6 Pages: 1536-1540
  • DOI: 10.1021/np500290a
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens. (2014)
  • Author(s): A. Furusato, H. Kato, T. Nehira, K. Eguchi, T. Kawabata, Y. Fujiwara, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, M. Takeya, H. Yokosawa, S. Tsukamoto
  • Journal Title: Org. Lett. Volume: 16 Issue: 15 Pages: 3888-3891
  • DOI: 10.1021/ol5015569
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Triterpenoids from the Fruits and Leaves of the Blackberry (Rubus allegheniensis) and Their Inhibitory Activities on Foam Cell Formation in Human Monocyte-Derived Macrophage (2014)
  • Author(s): M. Ono, S. Yasuda, H. Komatsu, Y. Fujiwara, M. Takeya, T. Nohara
  • Journal Title: Nat. Prod. Res. Volume: 28 Issue: 24 Pages: 839-844
  • DOI: 10.1080/14786419.2014.939087
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Detection of AGEs as markers for carbohydrate metabolism and protein denaturation (2014)
  • Author(s): Nagai R, Shirakawa J, Fujiwara Y, Ohno R, Moroishi N, Sakata N, Nagai M.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 55 Issue: 1 Pages: 1-6
  • DOI: 10.3164/jcbn.13-112
  • NAID: 130004466757
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration. (2014)
  • Author(s): Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y
  • Journal Title: Journal of Neurology Volume: 261 Issue: 11 Pages: 2209-2217
  • DOI: 10.1007/s00415-014-7491-8
  • Peer Reviewed / Open Access
• [Journal Article] ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice (2014)
  • Author(s): Kamikawa M, Lei XF, Fujiwara Y, Nishitsuji K, Mizuta H, Takeya M, Sakashita N
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 47 Issue: 2 Pages: 35-43
  • DOI: 10.1267/ahc.13033
  • NAID: 130003390848
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Isolation and Characterization of New Onionins A₂ and A₃ from <i>Allium cepa</i>, and of Onionins A₁, A₂, and A₃ from <i>Allium fistulosum</i> (2014)
  • Author(s): Toshihiro Nohara, Yukio Fujiwara, Rino Kudo, Koki Yamaguchi, Tsuyoshi Ikeda, Kotaro Murakami, Masateru Ono, Tetsuya Kajimoto, Motohiro Takeya
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 62 Issue: 11 Pages: 1141-1145
  • DOI: 10.1248/cpb.c14-00461
  • NAID: 130004712906
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition. (2014)
  • Author(s): Fujiwara Y, Takeya M, Komohara Y
  • Journal Title: Biomed Res Int Volume: 2014 Pages: 348539-348539
  • DOI: 10.1155/2014/348539
  • Peer Reviewed / Open Access
• [Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells (2013)
  • Author(s): Horlad Hasita, Fujiwara Yukio, Takemura Kenichi, Ohnishi Koji, Ikeda Tsuyoshi, Tsukamoto Hirotake, Mizuta Hiroshi, Nishimura Yasuharu, Takeya Motohiro, Komohara Yoshihiro
  • Journal Title: Mol. Nutri. Food Res Volume: 57 (6) Issue: 6 Pages: 1-9
  • DOI: 10.1002/mnfr.201200610
  • Peer Reviewed
• [Journal Article] Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo (2013)
  • Author(s): K.Eguchi, R.E.P.Mangindaan, S.Tsukamoto
  • Journal Title: Bioorg. Med. Chem. Volume: 21 Issue: 13 Pages: 3831-3838
  • DOI: 10.1016/j.bmc.2013.04.025
  • Peer Reviewed
• [Journal Article] Cyclic Sulfoxides Garlicnins B₂, B₃, B₄, C₂, and C₃ from <i>Allium sativum</i> (2013)
  • Author(s): Nohara Toshihiro; Fujiwara Yukio; Ikeda Tsuyoshi; Murakami Kohtaro; Ono Masateru; Nakano Daisuke; Kinjo Junei
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 61 Issue: 7 Pages: 695-699
  • DOI: 10.1248/cpb.c13-00082
  • NAID: 130003360797
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Saponins Esculeosides B-1 and B-2 in Italian Canned Tomatoes (2013)
  • Author(s): Manabe Hideyuki; Fujiwara Yukio; Ikeda Tsuyoshi; Ono Masateru; Murakami Kotaro; Zhou Jian-Rong; Yokomizo Kazumi; Nohara Toshihiro
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 61 Issue: 7 Pages: 764-767
  • DOI: 10.1248/cpb.c13-00202
  • NAID: 130003360799
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Role of Stat3 Activation in Cell-Cell Interaction between B-Cell Lymphoma and Macrophages : The <I>in vitro</I> Study (2013)
  • Author(s): Bing Bai, Hasita Horlad, Yoichi Saito, Koji Ohnishi, Yukio Fujiwara, Motohiro Takeya, Yoshihiro Komohara
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 53 Issue: 2 Pages: 127-133
  • DOI: 10.3960/jslrt.53.127
  • NAID: 10031194234
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed
• [Journal Article] Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling (2013)
  • Author(s): Fujiwara Yukio, Takaishi Kiyomi, Nakao Junko, Ikeda Tsuyoshi, Katabuchi Hidetaka, Takeya Motohiro, Komohara Yoshihiro
  • Journal Title: Oncology Letters Volume: 6 (6) Issue: 6 Pages: 1619-1623
  • DOI: 10.3892/ol.2013.1591
  • Peer Reviewed
• [Presentation] 硫黄含有化合物 ONA の腫瘍関連マクロファージの活性化制御を介した抗腫瘍効果の検討 (2016)
  • Author(s): 藤原章雄、中尾純子、野原稔弘、池田剛、片渕秀隆、竹屋元裕、菰原義弘
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-03-26
• [Presentation] Onionin A, a new sulfur-containing compound isolated from onion, impairs tumor development and lung metastasis by regulating macrophage activation (2015)
  • Author(s): Yukio Fujiwara, Yoshihiro Komohara, Hasita Horlad, Toshihiro Nohara, Motohiro Takeya
  • Organizer: THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] STAT3 経路の活性化を抑制するタマネギ成分ONA の抗腫瘍効果の検討 (2015)
  • Author(s): 藤原章雄、中尾純子、菰原義弘、野原稔弘、池田剛、片渕秀隆、竹屋元裕
  • Organizer: 第6回 食品薬学シンポジウム
  • Place of Presentation: 岡山、岡山大学創立五十周年記念館
  • Year and Date: 2015-10-30
• [Presentation] Expression of CD163 in macrophages is related to tumorigenesis in murine sarcoma model (2015)
  • Author(s): Yukio Fujiwara, Daisuke Shiraishi, Yoichi Saito, Motohiro Takeya, Yoshihiro Komohara
  • Organizer: 第74回 日本癌学会学術総会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2015-10-08
• [Presentation] Regulation of macrophage activation by natural compounds and unnatural compounds (2015)
  • Author(s): Yukio Fujiwara, Yoshihiro Komohara, Yuta Nakanishi, Yoshitaka Nakanishi, Motohiro Takeya
  • Organizer: Japan-the Netherlands Symposium on Soft-Tribiolgy
  • Place of Presentation: 熊本、熊本大学
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] マクロファージスカベンジャー受容体であるCD163の腫瘍増殖における機能性 (2015)
  • Author(s): 藤原章雄、白石大偉輔、Horlad Hasita、菰原義弘、水田博志、竹屋元裕
  • Organizer: 第55回 日本リンパ網内系学会総会
  • Place of Presentation: 岡山、岡山コンペンションセンター
  • Year and Date: 2015-07-09
• [Presentation] 腫瘍の進展におけるマクロファージヘモグロビンスカベンジャー受容体(CD163)の機能解析 (2015)
  • Author(s): 藤原章雄、白石大偉輔、Horlad Hasita、菰原義弘、水田博志、竹屋元裕.
  • Organizer: 第104回 日本病理学会総会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2015-04-30
• [Presentation] CD163, a scavenger receptor for the hemoglobin-haptoglobin complex, impair the excessive inflammatory responses in murine model of endotoxin shock. (2015)
  • Author(s): Yukio Fujiwara, Koji Ohnishi, Yoichi Saito, Daisuke Shiraishi, Hasita Horlad, Motohiro Takeya, Yoshihiro Komohara
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Fairmont The Queen Elizabeth, Montreal, QC, Canada
  • Year and Date: 2015-03-08 – 2015-03-13
• [Presentation] ミエロイド細胞の制御を介したOnionin A の抗腫瘍薬としての可能性 (2014)
  • Author(s): 藤原章雄
  • Organizer: 第20回 天然薬物の開発と応用シンポジウム
  • Place of Presentation: 東京大学、東京
  • Year and Date: 2014-11-05 – 2014-11-06
  • Invited
• [Presentation] ヘモグロビンスカベンジャー受容体（CD163）は炎症を抑制することで敗血症マウスの生存率を改善する (2014)
  • Author(s): 藤原章雄、大西紘二、西東洋一、菰原義弘、竹屋元裕
  • Organizer: 第87回 日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] CD163 is correlated with tumor proliferation in MCA205 sarcoma bearing mice. (2014)
  • Author(s): Yukio Fujiwara, Daisuke Shiraishi, Hasita Horlad, Yoichi Saito, Motohiro Takeya, Yoshihiro Komohara
  • Organizer: 第73回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Antitumor Allium Sulfides. (2014)
  • Author(s): Yukio Fujiwara, Kotaro Murakami, Tsuyoshi Ikeda, Masateru Ono, Motohiro Takeya, Toshihiro Nohara.
  • Organizer: The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy
  • Place of Presentation: Fukuoka University, Fukuoka, Japan
  • Year and Date: 2014-09-13
• [Presentation] LPS誘導性炎症に対するヘモグロビンスカベンジャー受容体（CD163）の抑制作用について (2014)
  • Author(s): 藤原章雄、大西紘二、西東洋一、菰原義弘、竹屋元裕
  • Organizer: 第67回 日本酸化ストレス学会学術集会
  • Place of Presentation: 同志社大学、京都
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] マクロファージの活性化を制御する硫黄含有化合物の抗腫瘍薬としての可能性 (2014)
  • Author(s): 藤原章雄、菰原義弘、竹屋元裕
  • Organizer: 第54回 日本リンパ網内系学会総会
  • Place of Presentation: 山形国際ホテル、山形
  • Year and Date: 2014-06-19 – 2014-06-21
• [Presentation] CD163 impair the excessive inflammatory responses in murine model of endotoxin shock. (2014)
  • Author(s): Yukio Fujiwara, Koji Ohnishi, Yoich Saito, Daisuke Shiraishi, Motohiro Takeya, Yoshihiro Komohara.
  • Organizer: The 22nd International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Kobe Chamber of Commerce and Industry, Kobe, Japan
  • Year and Date: 2014-06-02 – 2014-06-03
• [Presentation] マクロファージの活性化を制御する低分子化合物ONAの抗腫瘍薬としての可能性 (2014)
  • Author(s): 藤原章雄、菰原義弘、池田剛、野原稔弘、竹屋元裕
  • Organizer: 第103回 日本病理学会総会
  • Place of Presentation: 広島国際会議場、広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Enhancement of antitumor immunity by ONA, a natural compound: regulation of macrophage activation and suppression of tumor development in mouse tumor model. (2014)
  • Author(s): Yukio Fujiwara, Yoshihiro Komohara, Hasita Horlad, Daisuke Shiraishi, Toshihiro Nohara, Motohiro Takeya.
  • Organizer: The 12th Japanese-Korean Lymphoreticular Workshop 2014
  • Place of Presentation: Nagoya University Hospital (Nagoya)
• [Presentation] 低分子化合物ONAのマクロファージ活性化制御を介した抗腫瘍作用 (2014)
  • Author(s): 藤原章雄、菰原義弘、野原稔弘、竹屋元裕
  • Organizer: 日本薬学会 第134年会
  • Place of Presentation: 熊本大学（熊本）
• [Presentation] Onionin A regulates macrophage activation and suppresses tumor development by inhibiting stat3 activation. (2013)
  • Author(s): Yukio Fujiwara, Yoshihiro Komohara, Hasita Horlad, Daisuke Shiraishi, Koji Ohnishi, Motohiro Takeya.
  • Organizer: 21th International Synposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Toshi Center Hotel (Tokyo)
• [Presentation] マクロファージの活性化を制御する低分子硫黄化合物の抗腫瘍薬としての応用 (2013)
  • Author(s): 藤原章雄、菰原義弘、池田剛、野原稔弘、竹屋元裕.
  • Organizer: 日本ケミカルバイオロジー学会 第8回年会
  • Place of Presentation: 東京医科歯科大学（東京）
• [Presentation] ガン治療への応用を目指した免疫抑制性ミエロイド細胞を制御する化合物の探索 (2013)
  • Author(s): 藤原章雄、菰原義弘、Hasita Horlad、竹屋元裕
  • Organizer: 第10回 日本病理学会カンファレンス
  • Place of Presentation: 六甲山ホテル（神戸）
• [Presentation] 皮膚老化予防を目指したメイラード反応後期生成物の生成を阻害する生薬成分の探索 (2013)
  • Author(s): 藤原章雄、池田剛、永井竜児、竹屋元裕
  • Organizer: 第86回 日本生化学会大会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] マクロファージの活性化を制御する天然化合物ONAの骨肉腫モデルマウスにおける抗腫瘍作用 (2013)
  • Author(s): 藤原章雄、Hasita Horlad、白石大偉輔、菰原義弘、竹屋元裕
  • Organizer: 第72回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] AGEs生成を調節する天然物由来化合物 (2013)
  • Author(s): 藤原章雄
  • Organizer: 第５回 糖化ストレス研究会
  • Place of Presentation: 東京八重洲ホール（東京）
  • Invited
• [Presentation] 構造特異的AGEs抗体を用いた簡便なAGEs生成阻害物質のアッセイ法の開発と候補物質の効果検証 (2013)
  • Author(s): 藤原章雄、永井竜児、竹屋元裕
  • Organizer: 第23回 日本メイラード学会学術集会
  • Place of Presentation: ナレッジキャピタルコンベンションセンター（大阪）
• [Presentation] マクロファージの活性化とAGEsの活性化を制御する化合物の探索研究について (2013)
  • Author(s): 藤原章雄
  • Organizer: 生薬若手懇話会 第11回勉強会
  • Place of Presentation: 京都大学薬学部（京都）
• [Book] 別冊Bio Clinica 慢性炎症と疾患 (2016)
  • Author(s): 藤原章雄、菰原義弘、大西紘二、竹屋元裕
  • Total Pages: 172
  • Publisher: 北隆館
• [Book] ニューフードインダストリー 2月号 (2014)
  • Author(s): 藤原章雄、池田剛、竹屋元裕、菰原義弘
  • Total Pages: 96
  • Publisher: 食品資材研究会
• [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野ホームページ
  • URL: http://www.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野ホームページ
  • URL: http://www.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html