| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
It is well known that tumor-associated macrophages play an important role in tumor progression. In this study, we identified several natural compounds (corosolic acid, oleanolic acid and soyasapogenol etc.) as candidate compounds regulating macrophage activation and those compounds suppressed tumor proliferation under co-culture with macrophages and tumor cells. Furthermore, oral administration of those compounds significantly suppressed both tumor development and metastasis in a tumor-bearing mice. Therefore, these compounds may be potentially new tool for tumor prevention and therapy.
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