The role of adiponectin in appetite and feeding regulation of eating disorder

• Project/Area Number: 25860502
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kagoshima University
• Principal Investigator: Amitani Haruka 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (70535674)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 摂食障害 / 心身内科学

Outline of Final Research Achievements

Anorexia nervosa (AN) continues to be a refractory disease because of its unknown pathogenesis. The role of adiponectin in AN has not been clarified. Moreover, few reports have described the relations between adiponectin isoforms and AN in the physical and psychological states. Therefore, we measured plasma adiponectin and its isoforms levels in patients with AN to examine their roles in AN. Total and high molecular weight adiponectin levels were significantly decreased only in obesity although they tended to decrease in AN-R. There was no relationship between klotho and total adiponectin levels or klotho and respective adiponectin isoform levels in the entire study population.

Research Products

• [Presentation] 悪液質への栄養と治療 (2015)
  • Author(s): 網谷東方
  • Organizer: 日本摂食障害学会
  • Place of Presentation: パピヨン２４（福岡県福岡市】
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] 悪液質と栄養学 (2015)
  • Author(s): 網谷東方
  • Organizer: 日本心身医学会総会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] The relation between BMI and the anti-aging hormone, klotho (2015)
  • Author(s): ;Marie Amitani, Asakawa Akihiro, Haruka Amitani, Yasuhito Nerome, Tetsuhiro Owaki, Toshihiro Takezaki, Akio Inui
  • Organizer: Wonca Asia Pacific Regional Conference
  • Place of Presentation: Taiwan（Taipei）
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] 消化管ホルモンによる食行動・消化管運動調節 (2014)
  • Author(s): 浅川明弘，網谷東方，乾明夫
  • Organizer: 第22回日本消化器関連学会
  • Place of Presentation: 神戸（ポートピアホテル 神戸国際会議場）
  • Year and Date: 2014-10-25
• [Presentation] Association between adiponectin isoforms and anorexia nervosa.
  • Author(s): Amitani H, Asakawa A, Amitani M, Cheng KC, Morinaga M, Yoneda K, Inui A.
  • Organizer: 7th Cachexia Conference.
  • Place of Presentation: 兵庫県神戸市
• [Presentation] 神経性食欲不振症から見る摂食調節のメカニズム
  • Author(s): 網谷東方，浅川明弘，網谷真理恵，乾明夫
  • Organizer: 第91回日本生理学会
  • Place of Presentation: 鹿児島市