Establishment of novel diagnostic method for CIPO and elucidation of the pathology

• Project/Area Number: 25860503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yokohama City University
• Principal Investigator: OHKUBO Hidenori 横浜市立大学, 附属病院, 助教 (70622588)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性偽性腸閉塞症 / シネMRI / 慢性偽性腸閉塞 / データベース化 / 難治性疾患

Outline of Final Research Achievements

Chronic intestinal pseudo-obstruction(CIPO) is a severe digestive motility disorder. However, conventional modality such as abdominal CT or plain radiograph cannot show the dysmotility directly. We succeeded in visualizing the dysmotility more clearly and directly by using cine-MRI thanks to its high temporal/spatial resolution. Cine-MRI have a potential to be an effective novel diagnostic method for CIPO.In addition, we performed a histopathological analysis of surgical specimens, and tried to elucidate the pathophysiology of this disease.

Research Products

• [Journal Article] Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. (2014)
  • Author(s): Ohkubo H Nakajima A et al.
  • Journal Title: Neurogastroenterology and Motility Volume: 26 Issue: 4 Pages: 571-580
  • DOI: 10.1111/nmo.12303
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. (2013)
  • Author(s): Ohkubo H, Kessoku T, Fuyuki A, Iida H, Inamori M, Fujii T, Kawamura H, Hata Y, Nakajima A, Tkahara T
  • Journal Title: Am J Gastroenterol Volume: １０８ Issue: 7 Pages: 1130-9
  • DOI: 10.1038/ajg.2013.57
  • Peer Reviewed
• [Presentation] 消化管運動測定法の進歩：シネMRIを用いた検討から (2014)
  • Author(s): 大久保秀則、中島淳
  • Organizer: 第100回消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] シネMRIは慢性偽性腸閉塞症の小腸蠕動低下を明確に描出する：症例対照研究
  • Author(s): 大久保秀則、冬木晶子、飯田洋、稲森正彦、千葉俊美、松橋信行、眞部紀明、春間賢、高原太郎、中島淳
  • Organizer: 第15回神経消化器病学会
  • Place of Presentation: ビッグハート出雲（島根県出雲市）
• [Book] 腹部（消化管）MRI－MRIを用いた消化管疾患診断学の近年の進歩 (2013)
  • Author(s): 大久保秀則、冬木晶子、飯田洋、稲森正彦、高原太郎、中島淳
  • Total Pages: 6
  • Publisher: 診断と治療社