study of the pathogenesis of functional dyspepsia using breath test and ultrasonic method

• Project/Area Number: 25860505
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yokohama City University
• Principal Investigator: SEKINO Yusuke 横浜市立大学, 附属病院, 助教 (40622577)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 機能性胃腸症 / 呼気法 / 超音波法 / 飲水超音波法

Outline of Final Research Achievements

We revealed that oral sumatriptan administration enhanced gastric accommodation after the ingestion of liquid nutrients, but had no significant effect on antral contractions or intragastric distribution in healthy subjects.
Single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers. 100µg ramosetron pre-treatment enhances the early gastric emptying of liquid nutrients, but 5 µg ramosetron pre-treatment enhances the early gastric emptying of liquid nutrients. The gastric transit time（GTT） measured by （video capsule endoscopy）VCE cannot serve as asubstitute for the gastric emptying time measured by the 13C breath test.

Research Products

• [Journal Article] Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System). (2015)
  • Author(s): Inoue S, Sakamoto Y, Sekino Y, Nonaka T, Iida H, Endo H, Koide T, Takahashi H,Maeda S, Nakajima A, Gotoh E, Inamori M.
  • Journal Title: Turk J Gastroenterol. Volume: 26 Issue: 2 Pages: 123-7
  • DOI: 10.5152/tjg.2015.4768
  • Peer Reviewed
• [Journal Article] Correlation between gastric transit time measured by video capsule endoscopy and gastric emptying determined by the continuous real-time 13C breath test (BreathID system). (2014)
  • Author(s): Nonaka T, Inamori M, Endo H, Matsuura M, Uchiyama S, Yamada E, Sekino Y, SakaiE, Higurashi T, Ohkubo H, Akimoto K, Iida H, Takahashi H, Koide T, Shibata W, Ida T, Kusakabe A, Gotoh E, Nakajima A, Maeda S.
  • Journal Title: Hepatogastroenterology. Volume: 61 Pages: 2159-62
  • Peer Reviewed
• [Journal Article] Effects of ramosetron oral disintegrating tablets on gastric emptying: crossover study using the 13C-acetic acid breath test. (2014)
  • Author(s): Kusakabe A, Nonaka T, Sekino Y, Iida H, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Gotoh E, Maeda S, Nakajima A, Nosaka C, Inamori M.
  • Journal Title: Hepatogastroenterology. Volume: 61 Pages: 1279-82
  • Peer Reviewed
• [Journal Article] Inamori MEarly Effect of Single-dose Sitagliptin Administration on Gastric Emptying : Crossover Study Using the (13)C Breath Test (2013)
  • Author(s): Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Hosono K, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi N, Gotoh E, Maeda S, Nakajima A, Nosaka C
  • Journal Title: J Neurogastroenterol Motil. Volume: 19 Issue: 2 Pages: 227-32
  • DOI: 10.5056/jnm.2013.19.2.227
  • Peer Reviewed
• [Presentation] 呼気試験における早期胃排出遅延は近位胃弛緩を表すのか？ (2013)
  • Author(s): 野中敬、稲森正彦
  • Organizer: 日本平滑筋学会総会
  • Place of Presentation: 旭川市大雪クリスタルホール（北海道旭川市）