Development of a novel therapy targeting cancer stem-ike cells in Esophageal Cell Carcinoma
Project/Area Number |
25860512
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 食道扁平上皮癌 / 癌幹細胞 / 上皮間葉転換 / CD44 / EMT |
Outline of Final Research Achievements |
Cancer stem-like cells (CSCs) have been identified in many cancers and are thought to attribute to aggressive tumor behavior. CSCs can self-renew and have extremely high tumor initiating capacity. Furthermore, CSCs are highly invasive and resistant to conventional chemotherapy and radiation. Such characteristics of CSCs lead to recurrence, metastasis and inadequate response to the conventional therapies. A novel therapy targeting CSCs is needed to improve prognosis of Esophageal squamouscell carcinoma (ESCC). We have reported that Notch and TGF pathways are important in regulation of CSCs in ESCC. We have examined effects of Notch and TGF inhibitors on CSCs in the present study. These inhibitors suppress epithelial-mesenchymal transition (EMT) and significantly reduce CSCs in ESCC both in vitro and in vivo experiments. Notch and TGF pathways could be novel therapeutic targets against CSCs in ESCC.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment2014
Author(s)
Natsuizaka M, Kinugasa H, Kagawa S, Whelan KA, Naganuma S, Subramanian H, Chang S, Nakagawa KJ, Rustgi NL, Kita Y, Natsugoe S, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Rustgi AK and Nakagawa H.
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Journal Title
American journal of cancer research
Volume: 4
Pages: 29-41
Related Report
Peer Reviewed
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[Journal Article] Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor κB/mitogen-activated protein kinase.2014
Author(s)
Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatakaka K, Matsuno Y, Yokoo H, Kamiyama T, Taketomi A, Fujii G, Tashiro K, Hikiba Y, Fujimoto M, Asaka M, Maeda S
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Journal Title
Carcinogenesis
Volume: Epub ahead of print
Issue: 2
Pages: 272-281
DOI
Related Report
Peer Reviewed
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[Journal Article] CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using EUS-guided fine-needle aspiration and next-generation deep sequencing2014
Author(s)
Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N.
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Journal Title
Journal of gastroenterology
Volume: in press
Related Report
Peer Reviewed
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[Presentation] EGFR inhibitors eliminate esophageal cancer stem cells by suppressing epithelial-mesenchymal transition.2014
Author(s)
Mitsuteru Natsuizaka, Bongani Kaimila, Yoshimasa Kubota, Yutaka Hatanaka, Katsuji Marukawa, Katsumi Terashita, Fumiyuki Sato, Shunsuke Ohnishi, Goki Suda, Shinya Ohashi, Shingo Kagawa, Kelly Whelan, Anil K Rustgi, Hiroshi Nakagawa, Naoya Sakamoto
Organizer
Digestive Disease Week and the 115th annual meeting of the American Gastroenterological Association
Place of Presentation
McCormick Place (Chicago, USA)
Year and Date
2014-05-03 – 2014-05-06
Related Report
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[Presentation] Transforming Growth Factor-beta and Notch1 Cooperate to Repress NOTCH3 to Facilitate Epithelial-Mesenchymal Transition and Tumor Initiating Capability in Esophageal Squamous Cell Carcinoma2013
Author(s)
Natsuizaka M, Kagawa S, Whelan KA, Chang S, Kinugasa H, Ohashi S, Naganuma S, Sakamoto N, Klein-Szanto AJ, Gimotty PA, Diehl JA, Herlyn M, Rustgi AK, Nakagawa H.
Organizer
Digestive Disease Week and the 114th annual meeting of the American Gastroenterological Association
Place of Presentation
Orange county convention center (Orlando, USA)
Related Report
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