Development of a novel treatment with fetal membrane-derived mesenchymal stem cells to inflammatory bowel disesase
Project/Area Number |
25860515
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 炎症性腸疾患 / 間葉系幹細胞 / 卵膜 |
Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) have been reported to be a valuable cell source in cell therapy, and bone marrow (BM) represents a major source of MSCs; however, there are several limitations when using BM-MSCs, including inadequate cell numbers, invasiveness and donor site morbidity. Recently, several studies have shown that MSCs can be easily isolated from human fetal membrane (FM), and a large amount of cells can be obtained. We thus examined the therapeutic effects of transplantation of human FM-derived MSCs (hFM-MSCs) in dextran sulfate sodium (DSS)-induced colitis in rats. Transplantation of hFM-MSCs provided significant improvement in a rat model of severe colitis, possibly through inhibition of monocyte/macrophage activity. FM-MSC would be considered as a new cell source for the treatment of severe colitis.
|
Report
(4 results)
Research Products
(3 results)
-
-
[Presentation] Transplantation of human amnion-derived mesenchymal stem cells improves severe colitis via attenuation of macrophage activity in rats.2013
Author(s)
Ohnishi S, Onishi R, Higashi R, Yamahara K, Watari M, Kobayashi W, Katsurada T, Takeda H, Sakamoto N
Organizer
International Society for Stem Cell Research 2013
Place of Presentation
Boston Convention and Exhibition Center (Boston, massachusetts, USA)
Related Report
-