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Researching that global repression of miRNA function may cause inflammation-associated gastric and hepatic tumorigenesis

Research Project

Project/Area Number 25860520
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

Yoshikawa Takeshi  東京大学, 医学部附属病院, 特任臨床医 (40631685)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsmicroRNA / 炎症性発癌 / 肝癌
Outline of Final Research Achievements

I am researching "chronic impairment of microRNA function due to chronic inflammation may cause inflammation-associated tumorigenesis" and "preventing
inflammation-associated tumorigenesis". I published that ROCK inhibitor enhanced remaining miRNA function by promoting miRNA-mediated mRNA decay. And I am submitting the paper that global impairment of miRNA function in chronic inflammation may have a causal role in inflammation-associated colonic oncogenesis, and enhancement of miRNA function is a potential method for preventing colonic inflammation-associated tumorigenesis. This time I researched gastric and hepatic inflammation-associated tumorigenesis, but enhancement of miRNA function did not prevent inflammation-associated tumorigenesis of stomach and liver. Hereafter I will research molecular mechanism that global impairment of miRNA function contribute to inflammation-associated oncogenesis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (5 results)

  • [Journal Article] ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression2015

    • Author(s)
      Yoshikawa, T. Wu, J. Otsuka, M. Kishikawa, T. Ohno, M. Shibata, C. Takata, A. Han, F. Kang, Y. J. Chen, C. A. Shyu, A. B. Han, J. Koike, K
    • Journal Title

      Nucleic Acids Res

      Volume: 43(15) Issue: 15 Pages: 7577-89

    • DOI

      10.1093/nar/gkv728

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.2014

    • Author(s)
      Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Shibata C, Koike K.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 2 Pages: 173-84

    • DOI

      10.1007/s00535-013-0909-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.2013

    • Author(s)
      Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K.
    • Journal Title

      PLoS One.

      Volume: 8(9) Issue: 9 Pages: e71969-e71969

    • DOI

      10.1371/journal.pone.0071969

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Enhancing microRNA function may prevent colon carcinogenesis2014

    • Author(s)
      Yoshikawa T, Otsuka M, Koike K
    • Organizer
      JDDW 2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 慢性炎症に伴う大腸腫瘍発生におけるDicer遺伝子の特殊な癌抑制作用の解明2014

    • Author(s)
      吉川剛史 大塚基之 小池和彦
    • Organizer
      第100回 日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Obligate haploinsufficiency of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model2014

    • Author(s)
      Yoshikawa T, Otsuka M, Koike K
    • Organizer
      American Association for Cancer Research 2014
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Obligate haploinsufficiency of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model2014

    • Author(s)
      Yoshikawa T, Otsuka M, Koike K
    • Organizer
      American Association for Cancer Research 2014
    • Place of Presentation
      Sandiego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional impairment of microRNAs induced by chronic inflammation is the cause of inflammation-associated colon tumorigenesis2013

    • Author(s)
      Yoshikawa T, Otsuka M, Koike K
    • Organizer
      American Association for Cancer Research 2013
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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