Researching that global repression of miRNA function may cause inflammation-associated gastric and hepatic tumorigenesis
Project/Area Number |
25860520
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | microRNA / 炎症性発癌 / 肝癌 |
Outline of Final Research Achievements |
I am researching "chronic impairment of microRNA function due to chronic inflammation may cause inflammation-associated tumorigenesis" and "preventing inflammation-associated tumorigenesis". I published that ROCK inhibitor enhanced remaining miRNA function by promoting miRNA-mediated mRNA decay. And I am submitting the paper that global impairment of miRNA function in chronic inflammation may have a causal role in inflammation-associated colonic oncogenesis, and enhancement of miRNA function is a potential method for preventing colonic inflammation-associated tumorigenesis. This time I researched gastric and hepatic inflammation-associated tumorigenesis, but enhancement of miRNA function did not prevent inflammation-associated tumorigenesis of stomach and liver. Hereafter I will research molecular mechanism that global impairment of miRNA function contribute to inflammation-associated oncogenesis.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression2015
Author(s)
Yoshikawa, T. Wu, J. Otsuka, M. Kishikawa, T. Ohno, M. Shibata, C. Takata, A. Han, F. Kang, Y. J. Chen, C. A. Shyu, A. B. Han, J. Koike, K
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Journal Title
Nucleic Acids Res
Volume: 43(15)
Issue: 15
Pages: 7577-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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