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The Analysis of the immune evasion strategy by hepatitis C virus

Research Project

Project/Area Number 25860522
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NITTA Sayuri  東京医科歯科大学, 医歯(薬)学総合研究科, 特任助教 (20527056)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsC型肝炎 / 自然免疫応答 / ウイルス / 免疫学 / 細胞・組織 / インターフェロン
Outline of Final Research Achievements

Nearly 70% of HCV infected patients develop chronic hepatitis, which leads to liver cirrhosis and hepatocellular carcinoma. Some viral proteins of HCV have been reported to block the host antiviral immune response that could cause persistent infection and chronic hepatitis. In this study, we have shown that non-structural protein 4B of HCV, especially N-terminus of NS4B, inhibit both of the IFNβ and the IFNλ by targeting STING which is signal molecule of IFN pathway. These results are important to understand the HCV evasion system from host antiviral response and may contribute to develop novel anti-HCV drugs.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2013

    • Author(s)
      Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
    • Journal Title

      Hepatology

      Volume: 57 Issue: 1 Pages: 46-58

    • DOI

      10.1002/hep.26017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wnt5a Signaling Mediates Biliary Differentiation of Fetal Hepatic Stem/Progenitor Cells2013

    • Author(s)
      Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
    • Journal Title

      Hepatology

      Volume: (in press) Issue: 6 Pages: 2502-2513

    • DOI

      10.1002/hep.26293

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] HCV-NS4BのIFN-λ抑制作用に関する解析2014

    • Author(s)
      新田沙由梨、朝比奈靖浩、坂本直哉、後藤文男、谷口未樹、河合富貴子、大谷賢志、村川美也子、中川美奈、柿沼晴、渡辺守
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] HCV-NS4BはIFN-β発現誘導だけでなくIFN-λ発現誘導も抑制する

    • Author(s)
      新田 沙由梨
    • Organizer
      JDDW2013 第17回 日本肝臓学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] HCV-NS4BによるSTINGを標的とした自然免疫応答回避メカニズムの解析

    • Author(s)
      新田 沙由梨
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] HCV-NS4B protein blocks both type I and type III IFN production

    • Author(s)
      Nitta Sayuri
    • Organizer
      20th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Melborne, Australia
    • Related Report
      2013 Research-status Report
  • [Book] Liver Forum in Kyoto 第16回学術集会記録集2014

    • Author(s)
      新田沙由梨
    • Total Pages
      76
    • Publisher
      メディカルトリビューン
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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