| Project/Area Number |
25860523
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | C型肝炎ウイルス / MHC Class I / ウイルス / 免疫学 / インターフェロン誘導性遺伝子 / MHC Class 1 / シグナル伝達 |
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| Outline of Final Research Achievements |
For this study, we could not confirm induction of ISG expression by IFN- λ as we expected. Therefore, we tried to explore other possibility.
MHC Class I is a molecule that is known to support eradication of viruses. When cells are infected by viruses, part of virus protein is carried by MHC Class I to the surface of infected cells. Cytotoxic T cells recognize these protein conjugated MHC Class I molecules and attack these cells. As a result, viruses infecting these cells are eliminated with cells from host's body. For HCV, after infection or adding IFN-α, induction of MHC Class I expression was also confirmed (Kang et al, 2014). Therefore we planned to evaluate the results after adding IFN-λ, and found MHC Class I induction. From these results it was suggested that IFN-λ may also affect in the same mechanism as IFN-α.
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