Impacts of protein tyrosine phosphatase Shp2 on liver inflammation

Research Project

Project/Area Number	25860526
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Kanazawa University
Principal Investigator	NAGATA Naoto 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 (70456408)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	チロシンフォスファターゼ / 脂肪肝炎 / 過栄養
Outline of Final Research Achievements	Recently, non-alcoholic steatohepatitis has been rapidly increasing due to a high-fat diet and/or lack of exercise. Aim of this study is to investigate the role of Src homology phosphatase 2 (Shp2) in regulation of lipid metabolism and inflammation in the liver of mice model of NASH. This study revealed that liver-specific deficiency of Shp2 reduced lipid accumulation and inflammation in the liver of mice fed CDAA diet. I also found that Shp2 inhibitor partially improved CDAA diet-induced NASH. Taken together, Shp2 might be a novel molecular target of NASH.