Impacts of protein tyrosine phosphatase Shp2 on liver inflammation
| Project/Area Number |
25860526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAGATA Naoto 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 (70456408)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | チロシンフォスファターゼ / 脂肪肝炎 / 過栄養 |
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| Outline of Final Research Achievements |
Recently, non-alcoholic steatohepatitis has been rapidly increasing due to a high-fat diet and/or lack of exercise. Aim of this study is to investigate the role of Src homology phosphatase 2 (Shp2) in regulation of lipid metabolism and inflammation in the liver of mice model of NASH.
This study revealed that liver-specific deficiency of Shp2 reduced lipid accumulation and inflammation in the liver of mice fed CDAA diet. I also found that Shp2 inhibitor partially improved CDAA diet-induced NASH. Taken together, Shp2 might be a novel molecular target of NASH.
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Report
(3 results)
Research Products
(2 results)
