| Project/Area Number |
25860531
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
INATOMI OSAMU 滋賀医科大学, 医学部, 助教 (70530351)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膵線維化 / 筋線維芽細胞 / Wnt / 膵筋線維芽細胞 |
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| Outline of Final Research Achievements |
This study was designed to investigate the mechanism of pancreatic fibrogenesis via Wnt signaling in pancreatic myofibroblasts (activated stellate cells). Microarray assay showed that IL-1 stimulation induced the mRNA level of wnt2, 5a, and RUNX. On the other hands, TGF-β stimulation induced the mRNA level of Wnt 4, 9,11. Wnt 4 and 5a expression were significantly increased in the mild fibrotic area in the cerulean-induced chronic pancreatitis model mice. These findings suggest that Wnt signaling may be involved in pancreatic fibrogenesis in response to various inflammatory and fibrotic mediators.
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