The investigation of pathophysiology of inflammatory bowel disease with induced pluripotent stem cells
| Project/Area Number |
25860532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The Tazuke Kofukai (2015)
Kyoto University (2013-2014) |
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Principal Investigator |
YOSHINO Takuya 公益財団法人田附興風会, 医学研究所 第4研究部, 研究員 (10588875)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 炎症性腸疾患 / iPS細胞 / マクロファージ / エピゲノム |
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| Outline of Final Research Achievements |
Epigenetics would play an imporatant role in the etiology of inflammatory bowel disease (IBD). Therefore, we evaluate the function and DNA-methylation of macrophages derived from iPS cells comparing with those of intestinal macrophages.
iPS cells derived from patients with IBD could be established, although the accumulation of sufficient case has been difficult. We found several candidate gene by evaluating DNA-methylation analysis between macrophage dereived from iPS cells and intestinal macrophages. At present, we are working on accumulation of further cases and functional analysis of these genes.
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Report
(4 results)
Research Products
(21 results)
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[Presentation] 内視鏡index Q&A2016
Author(s)
吉野 琢哉、八隅 秀二郎
Organizer
日本炎症性腸疾患学会
Place of Presentation
国立京都国際会館、京都市、京都府
Year and Date
2016-07-10
Related Report
Invited
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