Analysis of the higher-order regulatory mechanism of LT-beta epigenome, leading to clinical application.
| Project/Area Number |
25860543
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | LTβ / NF-κB / CTCF / epigenetics / exosome / ゲノム / 遺伝子 / エピゲノム / 発現制御 / 予後予測 / ｴﾋﾟｹﾞﾉﾑ |
|---|
| Outline of Final Research Achievements |
Using the hepatic cell-line which NF-κB signal was activated constitutively, we showed that constant activation of NF-κB was important to activation of LTβ. In addition, we found the possibility of NF-κB as one of personalized medicine for the LT β overexpression group, because the expression of LTβ was controlled by NF-κB inhibitor.
・An tissue examination was necessary to confirm LTβ expression, conventionally. We found that LTβ in serum exosome could be detected quantitatively. We also found LTβ expression in the liver cancer tissue was in proportion to LTβ in serum exosome. In addition, the group highly expressed LTβ in exosome had a poorer prognosis than low expression group.
|
Report
(4 results)
Research Products
(30 results)
-
[Journal Article] The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.2016
Author(s)
Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR.
-
Journal Title
The Proceedings of the National Academy of Sciences
Volume: 11
Pages: 3054-3059
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Evaluation of sorafenib treatment and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: a comparative study using the propensity score matching method.2015
Author(s)
Fukubayashi K, Tanaka M, Izumi K, Watanabe T, Fujie S, Kawasaki T, Yoshimaru Y, Tateyama M, Setoyama H, Naoe H, Kikuchi K, Sasaki Y.
-
Journal Title
Cancer Medicine
Volume: 8
Pages: 1214-1223
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
[Journal Article] 定義と概念2013
Author(s)
渡邊丈久、田中基彦、佐々木裕
-
Journal Title
最新医学別冊 新しい診断と治療のABC 肝硬変 改訂第2版, 最新医学社
Volume: 44
Pages: 13-19
Related Report
-
-
[Journal Article] Pancreatic metastasis from mixed adenoneuroendocrine carcinoma of the uterine cervix: a case report.2013
Author(s)
Nishimura C, Naoe H, Hashigo S, Tsutsumi H, Ishii S, Konoe T, Watanabe T, Shono T, Sakurai K, Takaishi K, Ikuta Y, Chikamoto A, Tanaka M, Iyama K, Baba H, Katabuchi H, and Sasaki Y.
-
Journal Title
Case Reports in Oncology
Volume: 6
Pages: 256-262
Related Report
Peer Reviewed
-
[Presentation] Lymphotoxin-β regulated by NF-κB is a useful biomarker related to poor prognosis in hepatocellular carcinoma.2015
Author(s)
Takehisa Watanabe, Satomi Fujie, Akiyuki Tokunaga, Kazuhiro Izumi, Takeshi Kawasaki, Yoko yoshimaru, Hiroko Setoyama, Kotaro Fukubayashi, Masakuni Tateyama, Motohiko Tanaka1, and Yutaka Sasaki.
Organizer
AASLD2015
Place of Presentation
SAN FRANCISCO, CA
Year and Date
2015-11-13
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
