| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Using the hepatic cell-line which NF-κB signal was activated constitutively, we showed that constant activation of NF-κB was important to activation of LTβ. In addition, we found the possibility of NF-κB as one of personalized medicine for the LT β overexpression group, because the expression of LTβ was controlled by NF-κB inhibitor.
・An tissue examination was necessary to confirm LTβ expression, conventionally. We found that LTβ in serum exosome could be detected quantitatively. We also found LTβ expression in the liver cancer tissue was in proportion to LTβ in serum exosome. In addition, the group highly expressed LTβ in exosome had a poorer prognosis than low expression group.
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