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Association between the lipotoxicity of saturated fatty acids in the liver and pathophysiology of NASH.

Research Project

Project/Area Number 25860551
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYokohama City University

Principal Investigator

OGAWA Yuji  横浜市立大学, 附属病院, 指導診療医 (20644959)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords非アルコール性脂肪肝疾患 / 非アルコール性脂肪肝炎 / 飽和脂肪酸 / lipotoxicity / NAFLD / NASH / パルミチン酸
Outline of Final Research Achievements

The right jugular veins of C57BL/6 mice were catheterized. Then the mice were continuously infused with ethyl palmitate. Short-term palmitate treatment recruited neutrophil and macrophage to the liver, and activated hepatic stellate cell. Long-term palmitate treatment induced liver fibrosis. We showed that the saturated fatty acid, palmitate, induces nonalcoholic steatohepatitis(NASH)-like condition. The molecular interactions in this study could provide novel therapeutic targets for the treatment of NASH.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (10 results)

  • [Journal Article] Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.2014

    • Author(s)
      Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T
    • Journal Title

      World J Gastroenterol

      Volume: 20(29) Issue: 29 Pages: 10108-10114

    • DOI

      10.3748/wjg.v20.i29.10108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study.2014

    • Author(s)
      Imajo K, Hyogo H, Yoneda M, Honda Y, Kessoku T, Tomeno W, Ogawa Y, Taguri M, Mawatari H, Nozaki Y, Fujita K, Kirikoshi H, Saito S, Sumida Y, Ono M, Wada K, Nakajima A
    • Journal Title

      PLoS One

      Volume: 26 Issue: 12 Pages: e115403-e115403

    • DOI

      10.1371/journal.pone.0115403

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis.2014

    • Author(s)
      Imajo K, Yoneda M, Fujita K, Kessoku T, Tomeno W, Ogawa Y, Shinohara Y, Sekino Y, Mawatari H, Nozaki Y, Kirikoshi H, Taguri M, Toshima G, Takahashi J, Saito S, Wada K, Nakajima A.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 2 Pages: 295-304

    • DOI

      10.1007/s00535-013-0776-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbiota and nonalcoholic steatohepatitis.2014

    • Author(s)
      Imajo K, Yoneda M, Ogawa Y, Wada K, Nakajima A.
    • Journal Title

      Seminars in Immunopathology

      Volume: 36 Issue: 1 Pages: 115-132

    • DOI

      10.1007/s00281-013-0404-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Update: epidemiology and pathophysiology of nonalcoholic fatty liver disease.2014

    • Author(s)
      Ogawa Y, Imajo K, Yoneda M, Nakajima A.
    • Journal Title

      Nihon Shokakibyo Gakkai Zasshi.

      Volume: 111 Pages: 14-24

    • NAID

      130003383339

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lipotoxicity in liver induced by palmitate in vivo. 22nd United European Gastroenterology Week Free Paper Session Liver steatosis2014

    • Author(s)
      Ogawa Y, Honda Y, Kessoku T, Tomeno W, Imajo K, Mawatari H, Saito S, Nakajima A
    • Organizer
      22nd United European Gastroenterology Week
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2014-10-24 – 2014-10-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] パルミチン酸単独投与による肝臓への炎症細胞浸潤についての検討2014

    • Author(s)
      小川祐二, 今城健人, 中島淳
    • Organizer
      2014年度日本消化器関連学会週間(JDDW 2014)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] パルミチン酸単独投与による肝臓への炎症細胞浸潤と線維化についての検討2014

    • Author(s)
      小川祐二, 本多靖, 結束貴臣, 留野渉, 今城健人, 馬渡弘典, 斉藤聡, 中島淳
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学福浦キャンパス(神奈川県)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] パルミチン酸単独投与が引き起こす肝臓における自然免疫応答の検討2014

    • Author(s)
      小川祐二, 本多靖, 結束貴臣, 留野渉, 今城健人, 馬渡弘典, 斉藤聡, 中島淳
    • Organizer
      第51回日本消化器免疫学会総会
    • Place of Presentation
      京都大学医学部芝蘭会館(京都府)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] パルミチン酸単独投与による肝臓における自然免疫応答についての検討2014

    • Author(s)
      小川祐二, 今城健人, 中島淳
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of lipotoxicity in liver induced by palmitate in vivo.2014

    • Author(s)
      Ogawa Y, Honda Y, Kessoku T, Tomeno W, Imajo K, Mawatari H, Yoneda M, Kirikoshi H, Maeda S, Saito S, Wada K, Nakajima A
    • Organizer
      ADDW 2014
    • Place of Presentation
      Chicago(the United States of America)
    • Year and Date
      2014-05-04 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肝臓におけるパルミチン酸が引き起こすlipotoxityについてのin vivoでの検討2014

    • Author(s)
      小川祐二,本多靖,結束貴臣,今城健人,中島淳
    • Organizer
      第33回アルコール医学生物学研究会学術集会
    • Place of Presentation
      高知県立牧野植物園(高知)
    • Related Report
      2013 Research-status Report
  • [Presentation] パルミチン酸単独投与による2014

    • Author(s)
      小川 祐二,今城健人,中島 淳
    • Organizer
      第50回 肝臓病学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of lipotoxicity in liver induced by palmitate in vivo.2014

    • Author(s)
      Yuji Ogawa, Takaomi Kessoku, Kento Imajo, Atsushi Nakajima
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Chicago(United States of America)
    • Related Report
      2013 Research-status Report
  • [Presentation] パルミチン酸が引き起こす肝臓におけるlipotoxicityの検討2013

    • Author(s)
      小川 祐二,今城 健人,結束 貴臣,米田 正人,中島 淳
    • Organizer
      第10 回酸化ストレと肝研究会
    • Place of Presentation
      ANAクラウンプラザホテル福岡(福岡)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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