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Establishment of minimally invasive surgery for gastric cancer by nonexposed endoscopic wall-inversion surgery and sentinel node navigation surgery

Research Project

Project/Area Number 25860558
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

GOTO Osamu  慶應義塾大学, 医学部, 助教 (00589658)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords胃癌 / 低侵襲 / 内視鏡 / 腹腔鏡 / センチネルリンパ節 / 縮小手術 / 全層切除 / 局所切除 / 播種
Outline of Final Research Achievements

To establish a new method of minimally invasive surgery for gastric cancer, we conducted a porcine survival study of nonexposed endoscopic wall-inversion surgery (NEWS) with sentinel node navigation surgery (SNNS), and demonstrated the feasibility and safety of this combined surgery. After that, we started a pilot study of NEWS with SNNS for early gastric cancer which was candidate for surgery. Furthermore, to set an optimal surgical margin in the resection of gastric cancer by NEWS, the histological length of subepithelial lateral extent in surgically resected submucosal early gastric cancers was retrospectively investigated. The obtained results were reported at domestic or international congress and published in international journals.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] First case of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection for early gastric cancer2015

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Journal Title

      Gastric Cancer

      Volume: 18 Issue: 2 Pages: 434-439

    • DOI

      10.1007/s10120-014-0406-7

    • NAID

      40020581065

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Feasibility of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection as a new surgical method for early gastric cancer: a porcine survival study2015

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Journal Title

      Gastric Cancer

      Volume: 18 Issue: 2 Pages: 440-445

    • DOI

      10.1007/s10120-014-0358-y

    • NAID

      40020581072

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 医学と医療の最前線 胃粘膜下腫瘍へのアプローチ2015

    • Author(s)
      後藤修、他
    • Journal Title

      日本内科学会雑誌

      Volume: 104 Pages: 128-132

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Estimation of subepithelial lateral extent in submucosal early gastric cancer: retrospective histological analysis2014

    • Author(s)
      Goto O, et al.
    • Journal Title

      Gastric Cancer

      Volume: Epub ahead of print Issue: 4 Pages: 1-7

    • DOI

      10.1007/s10120-014-0427-2

    • NAID

      40020631571

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スキルアップESD 胃病変に対する全層切除のアプローチ2014

    • Author(s)
      後藤修、竹内裕也、他
    • Journal Title

      消化器内視鏡

      Volume: 26 Pages: 1304-1306

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 胃内視鏡治療の最前線 非穿孔式内視鏡的胃壁内反切除術(NEWS) 新しい胃癌低侵襲手術確立への挑戦2014

    • Author(s)
      後藤修、他
    • Journal Title

      医学のあゆみ

      Volume: 250 Pages: 947-952

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Expanding indications for ESD: Submucosal disease (SMT/carcinoid tumor)2014

    • Author(s)
      Goto O, et al.
    • Journal Title

      Gastrointestinal Endoscopy Clinics of North America

      Volume: Epub ahead of print Issue: 2 Pages: 169-181

    • DOI

      10.1016/j.giec.2013.11.006

    • Related Report
      2013 Research-status Report
  • [Presentation] NEWSとセンチネルリンパ節ナビゲーション手術の融合による新しい胃癌縮小手術2015

    • Author(s)
      前畑忠輝、後藤修、他
    • Organizer
      第87回日本胃癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2015-03-04 – 2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃粘膜下腫瘍に対する術式の比較検討2015

    • Author(s)
      庄司佳晃、竹内裕也、後藤修、他
    • Organizer
      第87回日本胃癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2015-03-04 – 2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] SM胃癌に対する内視鏡的全層切除術における適切な切離断端距離の検討2015

    • Author(s)
      後藤修、他
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-14 – 2015-02-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期胃癌に対するセンチネルリンパ節理論に基づいた低侵襲治療法の開発2015

    • Author(s)
      竹内裕也、後藤修、他
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-14 – 2015-02-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブタ切除胃を用いた非穿孔式内視鏡的胃壁内反切除術(NEWS)トレーニング2014

    • Author(s)
      前畑忠輝、後藤修、他
    • Organizer
      第99回日本消化器内視鏡学会関東支部例会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Histological analysis of subepithelial extent of submucosal early gastric cancer in 60 surgical cases2014

    • Author(s)
      Goto O, et al.
    • Organizer
      Asian Pacific Digestive Week
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食道胃接合部粘膜下腫瘍に対する治療戦略2014

    • Author(s)
      庄司佳晃、竹内裕也、後藤修、他
    • Organizer
      第76回日本臨床外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] NEWSによる胃SMT治療とセンチネルリンパ節理論との融合による早期胃癌治療の試み2014

    • Author(s)
      後藤修、竹内裕也、他
    • Organizer
      第88回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全層切除時代の早期胃癌範囲診断 - 側方伸展距離に関する病理学的検討2014

    • Author(s)
      後藤修、前畑忠輝、他
    • Organizer
      第88回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical cases of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection as a new concept of minimally invasive surgery for early gastric cancer2014

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      United European Gastroenterology Week
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腹腔鏡・内視鏡合同手術(LECS)による胃粘膜下腫瘍, 早期胃癌に対する低侵襲治療2014

    • Author(s)
      竹内裕也、後藤修、他
    • Organizer
      第98回日本消化器内視鏡学会関東支部例会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel full-thickness resection technique for gastric submucosal tumors and cancers2014

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      JGES-ASGE Joint Symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 胃SMTに対するNEWS治療成績と早期胃癌に対するNEWS+SNNS前臨床試験2014

    • Author(s)
      後藤修、竹内裕也、他
    • Organizer
      第87回日本消化器内視鏡学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Feasibility of non-exposed endoscopic wall-inversion surgery (NEWS) with sentinel node navigation surgery (SNNS) as a new method of minimally invasive local resection for early gastric cancer: a porcine survival study2014

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-05-02 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel full-thickness resection technique for gastric submucosal tumors and cancers

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      JGES-ASGE Joint Symposium
    • Place of Presentation
      Fukuoka (Japan)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 胃SMTに対するNEWS治療成績と早期胃癌に対するNEWS+SNNSの可能性

    • Author(s)
      後藤修、竹内裕也、他
    • Organizer
      第87回日本消化器内視鏡学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Feasibility of non-exposed endoscopic wall-inversion surgery (NEWS) with sentinel node navigation surgery (SNNS) as a new method of minimally invasive local resection for early gastric cancer: a porcine survival study

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      Digestive Disease Week 2014
    • Place of Presentation
      Chicago (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃粘膜下腫瘍、早期胃癌に対する腹腔鏡・内視鏡合同手術による低侵襲治療への試み

    • Author(s)
      竹内裕也、後藤修、他
    • Organizer
      第86回日本胃癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃粘膜下腫瘍、早期胃癌に対する腹腔鏡・内視鏡合同手術(LECS)による超低侵襲治療への挑戦

    • Author(s)
      竹内裕也、後藤修、他
    • Organizer
      第10回日本消化管学会学術集会
    • Place of Presentation
      ホテル福島グリーンパレス(福島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] New concept of minimally-invasive gastrectomy for early gastric cancer: feasibility of non-exposed endoscopic wall-inversion surgery (NEWS) with sentinel node navigation surgery (SNNS) in a porcine survival model

    • Author(s)
      Goto O, Takeuchi H, et al.
    • Organizer
      United European Gastroenterology Week 2013
    • Place of Presentation
      Berlin (Germany)
    • Related Report
      2013 Research-status Report
  • [Book] イラストと写真で見る内視鏡医と外科医のコラボレーション手術2014

    • Author(s)
      後藤修、竹内裕也、他
    • Total Pages
      176
    • Publisher
      メジカルビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 胃外科のすべて2014

    • Author(s)
      清水伸幸、後藤修、他
    • Total Pages
      352
    • Publisher
      メジカルビュー社
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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