Histological evaluation of superficial gastric lesions with confocal endomicroscopy

• Project/Area Number: 25860565
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: SUMIYAMA Kazuki 東京慈恵会医科大学, 医学部, 教授 (90385328)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 共焦点内視鏡 / 胃癌 / 国際共同研究 / 早期胃癌 / 国際情報交換

Outline of Final Research Achievements

Aims of this study were to evaluate the accuracy of deferential diagnosis for superficial gastric lesions (neoplastic or non-neoplastic) using a confocal laser endomicroscopy (CLE) and also to elucidate the influence of the reviewer’s clinical backgrounds over the CLE in collaboration with Western (Germany) and Eastern (Japan) institutions. We succeeded to obtain CLE images in all 49 cases without any clinical adverse events. The results of this study demonstrated that CLE provided detailed histological information of the gastric superficial lesions and the differential diagnosis with CLE was more accurate than that with the conventional endoscopic observation. The differential diagnosis of the reviewers’ clinical backgrounds influenced the interpretation of CLE for superficial gastric lesions. Reviewers in Japan with the higher prevalence of gastric cancer and gastroenterologists achieved better results in the CLE interpretation.

Research Products

• [Journal Article] 【消化器疾患に対する内視鏡的アプローチの最新情報】 共焦点内視鏡を用いた消化器画像診断 (2014)
  • Author(s): 小林雅邦、炭山和毅、田尻久雄
  • Journal Title: 映像情報Medical Volume: 46 Pages: 1346-1354
• [Journal Article] 進化を遂げる消化管内視鏡診断】 共焦点内視鏡を用いた消化管検査 (2014)
  • Author(s): 小林雅邦、炭山和毅、田尻久雄
  • Journal Title: 細胞 Volume: 46 Pages: 174-177
• [Journal Article] 共焦点内視鏡を用いた消化管検査 (2014)
  • Author(s): 小林雅邦，炭山和毅，田尻久雄
  • Journal Title: 月刊 細胞 The Cell Volume: 46 Pages: 22-25
• [Presentation] •INFLUENCE OF REVIEWERS' CLINICAL BACKGROUNDS OVER INTERPRETATION OF CONFOCAL LASER ENDOMICROSCOPY FOR SUPERFICIAL GASTRIC LESIONS. AN INTERNATIONAL MULTI-CENTRIC STUDY. (2014)
  • Author(s): Kazuki Sumiyama, Helmut Neumann, Masakuni Kobayashi, Seiichiro Abe, Yosuke Nakai, Michael Vieth, Kiyokazu Nakajima, Ralf Kiesslich, Hisao Tajiri
  • Organizer: UEGW 2014
  • Place of Presentation: オーストリア、ウィーン
  • Year and Date: 2014-10-22
• [Presentation] Upper GI diagnosis (2014)
  • Author(s): Kazuki Sumiyama
  • Organizer: UEGW 2014
  • Place of Presentation: オーストリア、ウィーン
  • Year and Date: 2014-10-20
  • Invited
• [Presentation] Confocal Endomicroscopy for Upper GI Neoplasia (2014)
  • Author(s): Kazuki Sumiyama
  • Organizer: DDW 2014
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2014-05-04
  • Invited
• [Presentation] Confocal Endomicroscopy for Upper GI Neoplasia (2014)
  • Author(s): Kazuki Sumiyama
  • Organizer: Digestive Diseaase Week 2014
  • Place of Presentation: Chicago, USA
  • Invited
• [Presentation] 1) Early gastric cancer diagnosis (NBI + magnification, confocal endomicroscopy) (2013)
  • Author(s): Kazuki Sumiyama
  • Organizer: The Asian Pacific Digestive Week/World Endoscopy Organization 2013
  • Place of Presentation: Shanghai, China
  • Invited
• [Presentation] 2) COMPARISON OF SUPERFICIAL GASTRIC NEOPLASIA DIAGNOSIS WITH A PROBE BASED CONFOCAL LASER ENDOMICROSCOPY (CLE) BETWEEN GASTROENTEROLOGY FELLOWS AND EXPERT ENDOSCOPISTS WITHOUT ANY CLINICAL EXPERIENCE OF CLE AFTER A BRIEF WEB-BASED TRAINING (2013)
  • Author(s): Kazuki Sumiyama
  • Organizer: United European Gastroenterology Week 2013
  • Place of Presentation: Berlin, Germany