Effect of prostaglandin on the voluntary movement in rats with experimental reflux esophagitis

• Project/Area Number: 25860569
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: KONDO Takashi 兵庫医科大学, 医学部, 助教 (90594870)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: GERD / NERD / プロスタグランジンE2 / 胸やけ / 胃食道逆流症 / 非ステロイド性抗炎症薬 / 胃食道逆流症（GERD) / 非びらん性胃食道逆流症（NERD) / PGE2 / 食道知覚

Outline of Final Research Achievements

We investigated the effects of diclofenac, a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production, on induction of esophageal sensation by acid perfusion in healthy men. We concluded that diclofenac attenuated acid-induced heartburn by inhibiting PGE2 overproduction in the esophagus. Esophageal PGE2 might be involved in producing heartburn symptoms. Further studies are needed to investigate the expression of PEG2 in the esophagus or in the peripheral/central nervous system of GERD patients, and to correlate such changes with GERD symptoms.

Research Products

• [Journal Article] The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers. (2015)
  • Author(s): Kondo T, Oshima T, Tomita T, Fukui H, Okada H, Watari J, Miwa H.
  • Journal Title: Clinical Gastroenterology and Hepatology Volume: in press Issue: 7 Pages: 1249-1255.e1
  • DOI: 10.1016/j.cgh.2015.01.014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prostaglandin E2 mediatesacid-induced heartburn in healthy volunteers. (2013)
  • Author(s): Kondo T, Oshima T, Tomita T, Fukui H, Watari J, Okada H, Kikuchi S, Sasako M, Matsumoto T, Knowles CH, Miwa H.
  • Journal Title: Am J Physiol GastrointestLiver Physiol. Volume: 304 Issue: 6 Pages: 568-73
  • DOI: 10.1152/ajpgi.00276.2012
  • Peer Reviewed
• [Presentation] 胸やけ症状発現メカニズムにおけるプロスタグランジンE2の関与 (2015)
  • Author(s): 近藤 隆、大島 忠之、山崎 尊久、河野 友彰、豊島 史彦、戸澤 勝之、池原 久朝、應田 義雄、富田 寿彦、福井 広一、渡 二郎、三輪 洋人
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-03 – 2015-04-05
• [Presentation] 胸やけ症状発現メカニズムへのプロスタグランジンE2の関与 (2014)
  • Author(s): 近藤 隆
  • Organizer: 第56回日本消化器病学会大会（JDDW2014）
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
  • Invited
• [Presentation] A Randomized Double-Blind Crossover Placebo-Controlled Study to Investigate the Effect of Nonsteroidal Anti-Inflammatory Drug on Acid-Induced Esophageal Sensation in Healthy Volunteers (2013)
  • Author(s): Kondo, T. Oshima, T. Tomita, T. Fukui, H. Watari, J. Okada, H. Miwa, H.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando, USA
• [Presentation] 非ステロイド性抗炎症薬の食道内プロスタグランジンと上腹部症状発現への効果に関する検討 (2013)
  • Author(s): 近藤 隆, 大島 忠之, 山崎 尊久, 李 兆亮, 奥川 卓也, 豊島 史彦, 櫻井 淳, 池原 久朝, 富田 寿彦, 福井 広一, 岡田 啓希, 中村 志郎, 渡 二郎, 三輪 洋人
  • Organizer: 第２１回 消化器関連学会週間
  • Place of Presentation: 東京