Effect of prostaglandin on the voluntary movement in rats with experimental reflux esophagitis
Project/Area Number |
25860569
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Hyogo Medical University |
Principal Investigator |
KONDO Takashi 兵庫医科大学, 医学部, 助教 (90594870)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | GERD / NERD / プロスタグランジンE2 / 胸やけ / 胃食道逆流症 / 非ステロイド性抗炎症薬 / 胃食道逆流症(GERD) / 非びらん性胃食道逆流症(NERD) / PGE2 / 食道知覚 |
Outline of Final Research Achievements |
We investigated the effects of diclofenac, a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production, on induction of esophageal sensation by acid perfusion in healthy men. We concluded that diclofenac attenuated acid-induced heartburn by inhibiting PGE2 overproduction in the esophagus. Esophageal PGE2 might be involved in producing heartburn symptoms. Further studies are needed to investigate the expression of PEG2 in the esophagus or in the peripheral/central nervous system of GERD patients, and to correlate such changes with GERD symptoms.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Prostaglandin E2 mediatesacid-induced heartburn in healthy volunteers.2013
Author(s)
Kondo T, Oshima T, Tomita T, Fukui H, Watari J, Okada H, Kikuchi S, Sasako M, Matsumoto T, Knowles CH, Miwa H.
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Journal Title
Am J Physiol GastrointestLiver Physiol.
Volume: 304
Issue: 6
Pages: 568-73
DOI
Related Report
Peer Reviewed
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[Presentation] 非ステロイド性抗炎症薬の食道内プロスタグランジンと上腹部症状発現への効果に関する検討2013
Author(s)
近藤 隆, 大島 忠之, 山崎 尊久, 李 兆亮, 奥川 卓也, 豊島 史彦, 櫻井 淳, 池原 久朝, 富田 寿彦, 福井 広一, 岡田 啓希, 中村 志郎, 渡 二郎, 三輪 洋人
Organizer
第21回 消化器関連学会週間
Place of Presentation
東京
Related Report