The possibility of CGRP as a therapeutic target and a biomarker for IBD
| Project/Area Number |
25860570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / CGRP / 神経ペプチド / バイオマーカー / 白血球除去療法 |
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| Outline of Final Research Achievements |
The aim of this study was to address the mechanism of action responsible for the effect of CGRP on colitis and the possibility of a biomarker for IBD. The result was that CGRP effectively suppresses colonic injury through the down-regulation of pro-inflammatory cytokines and the up-regulation of protective events, including bone marrow-derived cell induction, in addition to promoting colonic blood flow. CGRP is an attractive therapeutic target and a novel biomarker for UC patients.
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Report
(3 results)
Research Products
(7 results)
