The role of Zinc transporter in maintacnce of stemness of intestinal epithelial stem cell
| Project/Area Number |
25860573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Toyama |
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Principal Investigator |
OHASHI WAKANA 富山大学, 大学院医学薬学研究部(医学), 助教 (50381596)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腸管上皮細胞 / 亜鉛生物学 / 消化管 / 腸管上皮幹細胞 / ER / 亜鉛 / 亜鉛トランスポーター / 幹細胞 / トランスポーター |
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| Outline of Final Research Achievements |
In this study, we examined the role of zinc transporter Zip7 in the intestinal crypt homeostasis and found that Zip7 is essential for the proliferation of crypt cells and the maintenance of intestinal stem cells by regulating ER stress levels in crypt cells.
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Report
(3 results)
Research Products
(1 results)
