Molecular analysis of S100A8 protein and development of new treatment for metabolic syndrome and cardiovascular disease

• Project/Area Number: 25860587
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Hasumi Eriko 東京大学, 医学部附属病院, 助教 (70599547)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: S100A8 / アディポカイン / メタボリックシンドローム / 脂肪組織炎症 / S100A８ / S100A8蛋白 / インスリン抵抗性 / 新規アディポカイン

Outline of Final Research Achievements

Previous basic and clinical studies have shown that inflammation plays an essential role in metabolic diseases as well as atherosclerosis. However, it is still unclear how inflammation is initiated in obese adipose tissue. We found that expression of S100A8 increased in obese adipose tissues. It indicated that S100A8 play a important role for inflammation in adipose tissue. Since, we created S100A8 knockout mice to investigate the role of S100A8 in obese tissue. S100A8 knockout mice showed lower insulin sensitivity relative to foxed mice. This result suggested that S100A8 have a possibility of improving glucose homeostasis.

Research Products

• [Journal Article] Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture (2016)
  • Author(s): Eriko Hasumi
  • Journal Title: Cirulation J Volume: 80 Pages: 538-540
  • NAID: 130005120901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of multiple coronary artery-left ventricular micro fistulas complicated with hepatic arteriovenous fistulae (2016)
  • Author(s): Eriko Hasumi
  • Journal Title: Int Heart J Volume: 57 Pages: 123-126
  • NAID: 130005120997
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Direct left atrial ICE imaging guided ablation for atrial fibrillation without employing contrast medium. (2016)
  • Author(s): Matsubara TJ, Fujiu K, Asada K, et al.
  • Journal Title: Int J Cardiol Volume: 203 Pages: 733-739
  • DOI: 10.1016/j.ijcard.2015.11.038
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diagnostic implication of change in b-type natriuretic peptide (BNP) for prediction of subsequent target lesion revascularization following silorimus-eluting stent deployment. (2013)
  • Author(s): Eriko Hasumi, Hiroshi Iwata, Takahide Kohro, Ichiro Manabe, Koichiro Kinugawa, Naho Morisaki, Jiro Ando, Daigo Sawaki, Masao Takahashi, Hideo Fujita, Hiroshi Yamashita, Junya Ako, Yasunobu Hirata, Issei Komuro, Ryozo Nagai
  • Journal Title: International Journa of Cardiology Volume: 168(2) Pages: 1429-34
• [Presentation] S100A8は脂肪組織炎症の 新たなメディエーターである (2015)
  • Author(s): 荷見映理子
  • Organizer: 日本肥満学会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-02
  • Int'l Joint Research
• [Book] Electrocadiografy A to Z (2015)
  • Author(s): 荷見映理子
  • Total Pages: 4
  • Publisher: 医学書院