A study of role of phospholipase A2 and phospholipase A2 receptor in cardiovascular regeneration and development of new drug for cardiovascuar disease

• Project/Area Number: 25860591
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tokyo Metropolitan Institute of Medical Science (2014-2015); University of Yamanashi (2013)
• Principal Investigator: WATANABE Kazuhiro 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (50535549)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ホスホリパーゼA2受容体 / 心血管病 / PLA2受容体 / 心筋梗塞 / 血管新生 / 線維芽細胞

Outline of Final Research Achievements

This study was aimed to examine a possible role of secretory PLA2 and PLA2 receptor in cardiovascular regeneration, and to develop a new drug for prevention from cardiovascular diseases. As a result, PLA2R inhibit cardiac rupture after myocardial infarction by increasing migrations of fibroblasts to the infarcted lesion.

Research Products

• [Journal Article] c-type lectin domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen (2015)
  • Author(s): Soichiro Takahashi, Kazuhiro Watanabe et al.
  • Journal Title: FEBS Letter Volume: 589 Pages: 829-835
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction. (2014)
  • Author(s): Mishina H, Watanabe K, Tamaru S, Watanabe Y, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Inoue O, Murakami M, Hanasaki K, Kugiyama K.
  • Journal Title: Circ Res. Volume: 114 Issue: 3 Pages: 493-504
  • DOI: 10.1161/circresaha.114.302319
  • Peer Reviewed / Open Access