A study of role of phospholipase A2 and phospholipase A2 receptor in cardiovascular regeneration and development of new drug for cardiovascuar disease

Research Project

Project/Area Number	25860591
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular medicine
Research Institution	Tokyo Metropolitan Institute of Medical Science (2014-2015) University of Yamanashi (2013)
Principal Investigator	WATANABE Kazuhiro 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (50535549)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ホスホリパーゼA2受容体 / 心血管病 / PLA2受容体 / 心筋梗塞 / 血管新生 / 線維芽細胞
Outline of Final Research Achievements	This study was aimed to examine a possible role of secretory PLA2 and PLA2 receptor in cardiovascular regeneration, and to develop a new drug for prevention from cardiovascular diseases. As a result, PLA2R inhibit cardiac rupture after myocardial infarction by increasing migrations of fibroblasts to the infarcted lesion.

Report

(4 results)