| Project/Area Number |
25860594
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
MUROHARA TOYOAKI 名古屋大学, 医学系研究科, 教授 (90299503)
BANDO YASUKO 名古屋大学, 医学部附属病院, 講師 (60452190)
MORIMOTO RYOTA 名古屋大学, 医学系研究科, 寄附講座助教 (00755499)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 拡張型心筋症 / カテプシン |
|---|
| Outline of Final Research Achievements |
To clarify the pathophysiological role of cathepsin K, we investigated the association between the expression of cathepsin K and pathophysiological index, clinical imaging data, or prognosis in patients with dilated cardiomyopathy (DCM). The results of our studies were as follows; 1) Myocardial fibrosis and impaired left ventricular (LV) relaxation is more serious in late gadolinium enhancement positive group. Unfortunately, the expression of cathepsin K was not associated with the extent of fibrosis. 2) LV phase entropy using 99mTc-sestamibi gated myocardial perfusion SPECT, which may reflect impairment of Ca2+-handling caused by decreased SERCA2a mRNA levels, is a novel prognostic predictor of adverse cardiac events in patients with DCM with a narrow QRS complex. 3) The combined reduction of campesterol and lathosterol that indicated intestinal cholesterol absorption and liver synthesis predicts future cardiac events in patients with early-stage DCM.
|
