The impact of plasma heparin cofactor II activity in patients with aortic aortic aneurysm

• Project/Area Number: 25860605
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokushima
• Principal Investigator: ISE Takayuki 徳島大学, 大学病院, 助教 (90621649)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大動脈瘤 / Acute Aortic Syndrome / Acute Aortic Symdrome

Outline of Final Research Achievements

Progression of aortic aneurysms often cause fatal events such as rupture and dissection.Thrombin has a crucial role in vascular remodelig through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of vascular remodeling.We investigated the relationships between plasma HCII activity and presence of vascular disease, including aortic aneurusm, peripheral artery disease, coronary artery disease and cerebral artery disease.Plasma HCII activity was inversely associated with morbidity of vascular disease, including aortic aneurysm, peripheral artery disease, coronary artery disease and cerebral artery disease. This finding suggests that tissue thrombin inactivation by HCII is a novel therapeutic target for vascular remodeling and atherosclerosis.

Research Products

• [Journal Article] Response Prediction and Influence of Tolvaptan in Chronic Heart Failure Patients Considering the Interaction of the Renin-Angiotensin-Aldosterone System and Arginine Vasopressin (2016)
  • Author(s): Muneyuki Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, Rie Ueno, Yutaka Kawabata, Tomoya Hara, Kozue Ogasawara, Mika Bando, Sachiko Bando, Tomomi Matsura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, and Masataka Sata
  • Journal Title: International Heart Journal Volume: 57
  • NAID: 130006895903
  • Peer Reviewed
• [Journal Article] Effects of docosahexaenoic Acid on the endothelial function in patients with coronary artery disease. (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: J Atheroscler Thromb. Volume: 22 Pages: 447-454
  • NAID: 130004700298
  • Peer Reviewed
• [Journal Article] Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus. (2015)
  • Author(s): Yagi S, Aihara K, Akaike M, Fukuda D, Salim HM, Ishida M, Matsuura T, Ise T, Yamaguchi K, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Matsumoto T, Sata M.
  • Journal Title: Diabetes Metab J. Volume: 39 Pages: 342-347
  • Peer Reviewed
• [Journal Article] Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome. (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Nishimoto S, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: Nutr J Volume: 14 Pages: 111-111
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease (2015)
  • Author(s): Kimura S, Ueda Y, Ise T, Yagi S, Iwase T, Nishikawa K, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Katoh S, Akaike M, Yasui N, Sata M
  • Journal Title: International Heart Journal Volume: 56 Issue: 1 Pages: 105-109
  • DOI: 10.1536/ihj.14-161
  • NAID: 130004941282
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension (2015)
  • Author(s): Yagi S, Takashima A, Mitsugi M, Wada T, Hotchi J, Aihara K, Hara T, Ishida M, Fukuda D, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
  • Journal Title: Ther Clin Risk Manag Volume: 11 Pages: 112-112
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
  • Journal Title: J Atheroscler Thromb Volume: in press
  • NAID: 130004700298
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein. (2014)
  • Author(s): Takashima A, Ise T, Yagi S, Iwase T, Kimura S, Ueda Y, Nishikawa K, Ishii A, Niki T, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Katoh S, Akaike M, Sata M.
  • Journal Title: Circulation Journal Volume: 78 Pages: 2682-2687
  • NAID: 130004690797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Effect of Comprehensive Cardiac Rehabilitation on Oxidized stress in patients with heart failure (2014)
  • Author(s): 2)Takayuki Ise, Syusuke Yagi, Takashi Iwase, Masashi Akaike, Ayumi Ishii, Koji Nishikawa, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata.
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府, 大阪市）
  • Year and Date: 2014-10-12
• [Presentation] Impact of Cardiac Rehabilitation on Oxidized stress in patients with heart failure (2014)
  • Author(s): Takayuki Ise, Syusuke Yagi, Takashi Iwase, Masashi Akaike, Mika Bando, Sachiko Bando, Toshiyuki Niki, Junko Hotcchi, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京国際フォーラム(東京都)