Anti-atherogenic actions of DPP-4 inhibitor
Project/Area Number |
25860610
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Kumamoto University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 動脈硬化 / 内皮機能 / 炎症 / DPP4阻害剤 / GLP-1 / 抗動脈硬化 / インクレチン |
Outline of Final Research Achievements |
It have been shown that dipeptidyl peptidase 4 inhibitors (DPP4-I) have anti-atherosclerotic effects on the newly development process of atherosclerosis, however it is unknown whether DPP4-I also have anti-atherosclerotic effects on the established atheroma.Mice were fed by high fat diet (HFD) for 12 weeks, followed by randomized into 2 groups; HFD alone and HFD+DPP4-I for additional 8 weeks. DPP4-I-treatment significantly reduced the progression of established plaque compared to HFD alone.In clinical study, we investigated whether DPP4-I could improve endothelial dysfunction in diabetes mellitus (DM) patients with coronary artery disease (CAD). HbA1c levels significantly improved similarly in both groups (the additional treatment of DPP4-I or aggressive conventional treatment) for 6 months. DPP4-I significantly improved endothelial function in DM patients with CAD. These findings suggest that DPP4-I has beneficial effects on the cardiovascular system in DM patients.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Decreased plasma levels of active glucagon-like peptide-1 in coronary artery disease.2015
Author(s)
Akiyama E, Sugiyama S, Matsubara J, Kurokawa H, Konishi M, Nozaki T, Ohba K, Fujisue K, Maeda H, Sakamoto K, Sugamura K, Sumida H, Jinnouchi H, Sakamaki K, Morita S, Kimura K, Umemura S, Ogawa H.
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Journal Title
J Am Coll Cardiol.
Volume: 65
Issue: 7
Pages: 754-755
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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