Long non coding RANs regulate the cardiac lineage during embryonic stem cell differentiation
Project/Area Number |
25860621
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | long non coding RNA / non coding RNA / 長鎖非コードRNA / 長鎖non coding RNA |
Outline of Final Research Achievements |
Long non coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides, but they do not code proteins. LncRNAs constitute a heterogenic class of RNAs that includes intergenic RNAs, antisense transcripts, and enhancer RNAs. In recent, several studies have been reported that lncRNAs required for cardiac development and disease. It is obvious that many lncRNAs are expressed in cardiac development and are necessary for cardiovascular lineage. However, it has not been investigated in detail how lncRNAs are regulated in cardiac development and heart failure.Using embryonic stem cell (ESC) differentiation strategies, lncRNAs which restricted to cardiac cell were analyzed. In this study, to establish a map of lncRNAs expression and potential target gene networks during ESC differentiation. We identified the potential target genes of these lncRNAs through a bioinformatic correlation network that clusters lncRNAs into specific functional pathway.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Effective Cibenzoline Treatment in a Patient With Midventricular Obstruction After Transcatheter Aortic Valve Implantation.2016
Author(s)
Isobe S, Ieda M, Kohno T, Nishiyama T, Maekawa Y, Tsuruta H, Murata M, Yashima F, Yanagisawa R, Tanaka M, Inami S, Nasuno T, Haruyama A, Sano M, Hayashida K, Fukuda K.
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Journal Title
Circ Heart Fail
Volume: 9
Issue: 1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Diagnostic Accuracy of Commercially Available Automated External Defibrillators2015
Author(s)
Nishiyama T, Nishiyama A, Negishi M, Kashimura S, Katsumata Y, Kimura T, Nishiyama N, Tanimoto Y, Aizawa Y, Mitamura H, Fukuda K, Takatsuki S
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Journal Title
Journal of American Heart Associtation
Volume: 4
Related Report
Peer Reviewed / Open Access
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[Journal Article] Visualization of the left atrial appendage by phased-array intracardiac echocardiography from the pulmonary artery in patients with atrial fibrillation.2015
Author(s)
Nishiyama T, Katsumata Y, Inagawa K, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Aizawa Y, Tanimoto K, Fukuda K, Takatsuki S.
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Journal Title
Europace
Volume: 17
Issue: 4
Pages: 546-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Electrical superior vena cava isolation using photodynamic therapy in a canine model.2015
Author(s)
Kimura T, Takatsuki S, Miyoshi S, Takahashi M, Ogawa E, Nakajima K, Kashimura S, Katsumata Y, Nishiyama T, Nishiyama N, Tanimoto Y, Aizawa Y, Arai T, Fukuda K.
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Journal Title
Europace
Volume: 2
Issue: 2
Pages: 294-300
DOI
Related Report
Peer Reviewed
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[Journal Article] MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.2014
Author(s)
Mizuha Akiyama, Rie Wada, Kohei Inagawa, Takahiko Nishiyama, Ruri Kaneda, Toru Fukuda, Shu Takeda, Shugo Tohyama, Hisayuki Hashimoto, Yoshifumi Kawamura, Naoki Goshima, Ryo Aeba, Hiroyuki Yamagishi, Keiichi Fukuda, Masaki Ieda
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Journal Title
EMBO J.
Volume: 33
Issue: 14
Pages: 1565-1581
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014
Author(s)
Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
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Journal Title
J.Mol. Cell. Cardiol.
Volume: S0022-2828(14)
Pages: 97-2
DOI
Related Report
Peer Reviewed
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[Journal Article] Thoracic impedance as a therapeutic marker of acute decompensated heart failure.2014
Author(s)
Aizawa Y, Takatsuki S, Kashimura S, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Tanimoto K, Fukuda Y, Sato T, Ogawa S, Fukuda K.
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Journal Title
Int J Cardiol
Volume: 174
Pages: 840-2
Related Report
Peer Reviewed
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