The Relationship between Eukaryotic Translation Initiation Factor 2 Alfa and Ischemic Reperfusion Injury
Project/Area Number |
25860622
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 途絶心筋 / 心筋プレコンディショニング / 虚血再灌流障害 / ストレス応答ホルモン / 小胞体ストレス / 遺伝子改変マウス / ミトコンドリア障害 / 酸化ストレス / eif2α / 虚血再灌流傷害 |
Outline of Final Research Achievements |
A change of cardiac function after ischemic-perfusion injury has two types; myocardial stunning (transient cardiac dysfunction) and ischemic preconditioning (tolerance to ischemia). We hypothesized that eukaryotic translation initiation factor2α (eIF2α) was related to myocardial stunning and ischemic preconditioning. First of all, we made genetically modified mice whose elF2α in hearts could be controlled at arbitrary level. When eIF2α was moderately activated, the mice hearts showed tolerance to ischemic-perfusion injury. And when eIF2α was highly activated, transient cardiac dysfunction emerged. Then we demonstrated the relationship between eIF2α and ischemic-reperfusion injury with genomic, metabolomic, calcium dynamic analysis and electron microscopes.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction2014
Author(s)
Yan X, Hegab AE, Endo J, Anzai A, Matsuhashi T, Katsumata Y, Ito K, Yamamoto T, Betsuyaku T, Shinmura K, Shen W, Vivier E, Fukuda K, Sano M
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Journal Title
Circ Res
Volume: 114(4)
Issue: 4
Pages: 637-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation.2014
Author(s)
Kimura T, Takatsuki S, Inagawa K, Katsumata Y, Nishiyama T, Nishiyama N, Fukumoto K, Aizawa Y, Tanimoto Y, Tanimoto K, Fukuda K.
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Journal Title
Heart Lung Circ.
Volume: 14
Issue: 7
Pages: 636-43
DOI
Related Report
Peer Reviewed
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[Journal Article] Temporal dynamics of cardiac immune cell accumulation following a cute myocardial infarction2013
Author(s)
Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, Yamamoto T, Takeshima A, Shinmura K, Shen W, Fukuda K, Sano M
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 62
Pages: 24-35
DOI
Related Report
Peer Reviewed
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