| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
A total of 30 patients with clinically diagnosed MVO were investigated and Informed consent was obtained from each patient for gene analysis, and then clinical date were registered. Possible disease-causing mutations were found 20% in this cases. But mutations in sarcomere protein genes were found only MYBPC3 and nebulette, and the others are disease-causing mutations of Fabry-disease and dilated cardiomyopathy.So genetic background of MVO may be considerably different from common type of HCM.
Further MYL3 and MYL2 mutation were reported to disease-causing mutatiom of MVO by Europeans and Americans, but those mutation can't be found by this research and can consider a possibility that the pattern of the cause genetic mutation is different in Europeans and Americans and Japanese by this research.
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